Prostacyclin and Thromboxane A2 in Platelet Vessel Wall Interactions

  • Salvador Moncada
Conference paper


Prostacyclin was originally found as a product of the conversion of prostaglandin endoperoxides by a microsomal enzyme from blood vessels. It was described as an unstable substance which is a potent vasodilator and an inhibitor of platelet aggregation (Moncada et al. 1976a). This compound, originally called PGX (Bunting et al. 1976; Gryglewski et al. 1976; Moncada et al. 1976b), was later chemically identified by Johnson et al. (1976) as an intermediate in the formation of 6-oxo- PGF,1α compound already known (Dawson et al. 1976; Pace-Asciak 1976). PGX was then renamed prostacyclin and given the abbreviation of PGI2


Arachidonic Acid Platelet Aggregation Bleeding Time Prostaglandin Endoperoxide Prostacyclin Production 
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  • Salvador Moncada

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