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Biochemical Studies on Permeability and the Interaction Between Blood Constituents and Arterial Components in Atherosclerosis

  • Elspeth B. Smith
Conference paper

Abstract

It is now accepted that large amounts of plasma low density lipoprotein (LDL), and cholesterol ester which must be derived from it, accumulate in atherosclerotic lesions, but it is not clear if this is the result of increased endothelial permeability or of increased retention within the intima. In this paper I will try to draw together some of the available biochemical evidence.

Keywords

Evans Blue Endothelial Permeability Fatty Streak Internal Elastic Lamina Mural Thrombus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Armstrong ML, Megan MB, Warner EM (1978) The relation of hypercholesterolemic fatty streaks to intimai permeability changes shown by Evans blue. Atherosclerosis 31: 443PubMedCrossRefGoogle Scholar
  2. Bell FP, Adamson IL, Schwartz CJ (1974a) Aortic permeability to albumin: focal and regional patterns of uptake and transmural distribution of 131-1-albumin in the young pig. Exp Mol Pathol 20: 57PubMedCrossRefGoogle Scholar
  3. Bell FP, Gallus AS, Schwartz CJ (1974b) Focal and regional patterns of uptake and the transmural distribution of 131-I-fibrinogen in the pig aorta in vivo. Exp Mol Pathol 20: 281PubMedCrossRefGoogle Scholar
  4. Bratzler RL, Chisolm GM, Colton CK, Smith KA, Zilversmit DB, Lees RS (1977a) The distribution of labelled albumin across the rabbit thoracic aorta in vivo. Circulation Res 40: 182PubMedGoogle Scholar
  5. Bratzler RL, Chisolm GM, Colton CK, Smith KA, Lees RS (1977b) The distribution of labelled low-density lipoproteins across the rabbit thoracic aorta in vivo. Atherosclerosis 28: 289PubMedCrossRefGoogle Scholar
  6. Fry DL (1973) Responses of the arterial wall to certain physical factors. In: Atherogenesis: Initiating factors. Ciba Foundation Symposium (New Series) 12: 93Google Scholar
  7. Gerrity RG, Richardson M, Somer JB, Bell FP, Schwartz CJ (1977) Endothelial cell morphology in areas of in vivo Evans blue uptake in the aorta of young pigs. Am J Pathol 89: 313PubMedGoogle Scholar
  8. Hoff HF, Gaubatz JW, Gotto AM (1978a) Apo B concentration in the normal human aorta. Biochem Biophys Res Com 84: 1424CrossRefGoogle Scholar
  9. Hoff HF, Heideman CL, Gaubatz JW, Titus JL, Gotto AM (1978b) Quantitation of apo B in human aortic fatty streaks. Atherosclerosis 30: 263PubMedCrossRefGoogle Scholar
  10. Hollande W (1967) Influx, synthesis and transport of arterial lipoproteins in atherosclerosis. Exp Mol Pathol 7: 248CrossRefGoogle Scholar
  11. Hollande W (1976) Unified concept on the role of acid mucopolysaccharides and connective tissue proteins in the accumulation of lipids, lipoproteins and calcium in the atherosclerotic plaque. Exp Mol Pathol 25: 106CrossRefGoogle Scholar
  12. Minick CR, Stemerman MB, Insul W (1977) Effect of regenerated endothelium on lipid accumulation in the arterial wall. Proc Natl Acad Sci USA 74: 1724CrossRefGoogle Scholar
  13. Morrison AD, Berwick L, Orci L, Winegrad AI (1976) Morphology and metabolism of an aortic intima-media preparation in which an intact endothelium is preserved. J Clin Invest 57: 650PubMedCrossRefGoogle Scholar
  14. Packham MA, Rowsell HC, Jorgensen L, Mustard JF (1967) Localized protein accumulation in the wall of the aorta. Exp Mol Pathol 7: 214PubMedCrossRefGoogle Scholar
  15. Siflinger A, Parker K, Caro CG (1975) Uptake of 125-I-albumin by the endoth-elial surface of the isolated dog common carotid artery: effect of certain physical factors and metabolic inhibitors. Cardiovasc Res 9: 478PubMedCrossRefGoogle Scholar
  16. Smith EB (1974) The relationship between plasma and tissue lipids in human atherosclerosis. Advan Lipid Res 12: 1Google Scholar
  17. Smith EB (1980) Transport of macromolecules across the artery wall. This volumeGoogle Scholar
  18. Smith EB, Craig IB, Dietz HS (1978) Factors influencing accumulation and destruction of lipoprotein in atherosclerotic lesions. In: Carlson LA, Paoletti R, Sirtori CR, Weber G (eds) International Conference on Atherosclerosis, Raven Press, New York, p 49Google Scholar
  19. Smith EB, Dietz HS, Craig IB (1979a) Characterization of free and tightly bound lipoprotein in intima by thin layer isoelectric focusing. Atherosclerosis 33: 329PubMedCrossRefGoogle Scholar
  20. Smith EB, Massie IB, Alexander KM (1976) The release of an immobilized lipoprotein fraction from atherosclerotic lesions by incubation with plasmin. Atherosclerosis 25: 71PubMedCrossRefGoogle Scholar
  21. Smith EB, Staples EM, Dietz HS, Smith RH (1979) Role of endothelium in sequestration of lipoprotein and fibrinogen in aortic lesions, thrombi and graft pseudo-intimas. Lancet ii: 812CrossRefGoogle Scholar
  22. Stefanovich V, Gor I (1971) Cholesterol diet and permeability of rabbit aorta. Exp Mol Pathol 14: 20PubMedCrossRefGoogle Scholar
  23. Thorgeirsson G, Robertson AL (1978) The vascular endothelium — pathobiologic significance. Am J Pathol 93: 803PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1980

Authors and Affiliations

  • Elspeth B. Smith

There are no affiliations available

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