Abstract
Changes in plasma lipids and in lipoprotein distribution are well known consequences of the application of hypolipidemic drug regimens. In particular, VLDL lipids decrease with concomitant transient or permanent LDL cholesterol increases (Carlson et al. 1977); according to some reports also HDL cholesterol levels may increase following clofibrate (Wallentin 1978) or nicotinic acid treatments (Blum et al. 1977). Newer clofibrate derivatives appear more likely to increase HDL cholesterol (Olsson and Lang, 1978).
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References
Avogaro P, Bittolo Bon G, Cazzolato G and Quinci GB (1979) Are lipopro-teins better discriminators than lipids for atherosclerosis? Lancet i: 901–903
Bar-On H, Roheim PS and Eder HA (1976) Serum lipoproteins and apolipoproteins in rats with streptozotocin diabetes. J Clin Invest 57: 714–721
Blum CB, Levy RI, Eisenberg S, Hall M III, Goebel RH and Berman M (1977) High density lipoprotein metabolism in man. J Clin Invest 60: 795–806
Bradby GVH, Valente AJ and Walton KW (1978) Serum high-density lipoproteins in peripheral vascular disease. Lancet ii: 271–1274
Carlson LA, Olsson AG and Ballantyne D (1977) On the rise in low density and high density lipoproteins in response to the treatment of hyper-triglyceridemia in type IV and V hyperlipoproteinemias. Atherosclerosis 26: 603–609
Crepaldi G, Briani G, Senin U, Montaguti V, Capurso A and Bondioli A (1978) Multicenter trial with tiadenol in primary hyperlipidemias. In: LA Carlson et al. (eds) International Conference on Atherosclerosis, Raven Press, New York, pp 343–346
Goldstein JL and Brown MS (1977) Atherosclerosis: the low density lipoprotein receptor hypothesis. Metabolism 26: 1257–1275
Ishikawa TT, Mc Neely S, Steiner PM, Glueck CJ, Mellies M, Gartside PS and Mc Millin C (1978) Effects of chlorinated hydrocarbons or plasma α-lipoprotein cholesterol in rats. Metabolism 27: 89–96
La Rosa JC, Levy RI, Herbert P, Lux SE and Fredrickson DS (1970) A specific apoprotein activator for lipoprotein lipase. Biochim Biophys Res Comm 41: 57–62
Martin E and Feldma G (1974) Etude hystologique et ultrastructural du foie chez le rat après administration subaigue d’un nouvel agent hypolipidemiant, le bis (hydroxyethyl-thio) 1-10 decane. Pathol Biol, 22-11: 179–188
Nikkila EA, Huttunen JK and Ehnhol C (1977) Effect of clofibrate on post-heparin plasma triglyceride lipase activities in patients with hyper-triglyceridemia. Metabolism 26: 179–186
Nikkila EA (1978) Metabolic endocrine control of plasma high density lipoprotein concentrations. In: AM Gotto Jr et al. (eds) High density lipoproteins and atherosclerosis. Elsevier/North Holland, pp 177–192
Olsson AG and Lang PD (1978) Dose-response study of bezafibrate on serum lipoprotein concentrations in hyperlipoproteinemia. Atherosclerosis 31: 421–428
Reggian G (1978) Medical problems raised by the TCDD contamination in Seveso, Italy. Arch Toxicol 40: 161–188
Sirtori CR, Catapano A, Ghiselli GC, Innocenti AL and Rodrigue J (1977) Metformin: an antiatherosclerotic agent modifying very low density lipoproteins in rabbits. Atherosclerosis 26: 78–89
Sirtori CR, Catapano A, Ghiselli GC, Shore B and Shore VG (1978) Effects of metformin on lipoprotein composition in rabbits and man. Prot Biol Fluids 25: 379–382
Wallenti L (1978) Lecithin: cholesterol acyl transfer rate and high density lipoprotein in plasma during dietary and clofibrate treatment of hypertriglyceridemic subjects. Atherosclerosis 31: 41–52
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Sirtori, C.R., Franceschini, G., Sirtori, M., Gianfranceschi, G., Poli, A. (1980). Apoprotein Changes Following Treatments with Hypolipidemic Drugs. In: Gotto, A.M., Smith, L.C., Allen, B. (eds) Atherosclerosis V. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6071-4_19
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DOI: https://doi.org/10.1007/978-1-4612-6071-4_19
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