Abstract
The monogenic disorder familial hypercholesterolemia (FH) is associated with a high risk of premature coronary arteriosclerosis, largely attributable to a 2-3 fold increase in levels of low density lipoproteins (LDL) in serum. Heretofore, no regimen of drug therapy or surgical intervention has been reported which is capable of lowering levels of low density lipoproteins consistently to normal in FH heterozygotes. Regimens employing bile acid binding resins, nicotinic acid, neomycin and paraaminosalicylic acid individually have achieved reductions of serum cholesterol of only 25-30%, nearly comparable to the effect of partial ileal bypass, (33%) (Miettinen and Lempinen 1977). Combinations of clof ibrate with bile acid resins or neomycin are only slightly more effective than these agents given individually.
This research was supported by a Grant from the National Institutes of Health (Arteriosclerosis SCOR HL 14237). Dr. Kane was an Established Investigator of the American Heart Association.
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References
Blum CB et al. (1977) High density lipoprotein metabolism in man. J Clin Invest 60: 795–807
Eisenberg S, Levy RI (1975) Lipoprotein metabolism. Adv Lipid Res 13: 1–89
Goodman DS et al. (1973) The effects of colestipol resin and of colestipoi plus clofibrate on the turnover of plasma cholesterol in man. J Clin Invest 52: 2646–2658
Langer T, Levy RI (1971) The effect of nicotinic acid on the turnover of low density lipoproteins in type II hyperlipoproteinemia. In: Gey KK, Carlson LA (eds) Metabolic effects of nicotinic acid and its derivatives. Hans Huber, Bern
Magide AA et al. (1975) The effect of nicotinic acid on the metabolism of the plasma lipoproteins of rhesus monkeys. Atherosclerosis 21: 205–215
Miettinen TA (1968) Effect of nicotinic acid on catabolism and synthesis of cholesterol in man. Clin Chim Acta 20: 43–51
Miettinen TA, Lempine M (1977) Choiestyramine and ileal bypass in the treatment of familial hyperchoiesterolemia. J Clin Invest 7: 509–514
Moutafis CD et al. (1971) Choiestyramine and nicotinic acid in the treatment of familial hyperbetalipoproteinaemia in the homozygous form. Atherosclerosis 14: 247–258
Myers LH et al, (1976) Mathematical evaluation of methods of estimation of the concentration of the major lipid components of human serum lipoproteins. J Lab Clin Med 88: 491–505
Shepherd J et al. (1979) Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism. J Clin Invest 63: 858–867
Sodhi HS et al. (1971) Effects of chlorophenoxyisobutyrate on the synthesis and metabolism of cholesterol in man. Metabolism 20: 348–359
Wolfe BM et al. (1973) Mechanism of the hypolipemic effect of clofibrate in post absorptive man. J Clin Invest 52: 2146–2159
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© 1980 Springer-Verlag New York Inc.
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Kane, J.P., Tun, P., Malloy, M.J., Havel, R.J. (1980). Synergism in Drug Treatment of Familial Hypercholesterolemia. In: Gotto, A.M., Smith, L.C., Allen, B. (eds) Atherosclerosis V. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6071-4_16
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DOI: https://doi.org/10.1007/978-1-4612-6071-4_16
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