Abstract
The monogenic disorder familial hypercholesterolemia (FH) is associated with a high risk of premature coronary arteriosclerosis, largely attributable to a 2-3 fold increase in levels of low density lipoproteins (LDL) in serum. Heretofore, no regimen of drug therapy or surgical intervention has been reported which is capable of lowering levels of low density lipoproteins consistently to normal in FH heterozygotes. Regimens employing bile acid binding resins, nicotinic acid, neomycin and paraaminosalicylic acid individually have achieved reductions of serum cholesterol of only 25-30%, nearly comparable to the effect of partial ileal bypass, (33%) (Miettinen and Lempinen 1977). Combinations of clof ibrate with bile acid resins or neomycin are only slightly more effective than these agents given individually.
This research was supported by a Grant from the National Institutes of Health (Arteriosclerosis SCOR HL 14237). Dr. Kane was an Established Investigator of the American Heart Association.
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© 1980 Springer-Verlag New York Inc.
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Kane, J.P., Tun, P., Malloy, M.J., Havel, R.J. (1980). Synergism in Drug Treatment of Familial Hypercholesterolemia. In: Gotto, A.M., Smith, L.C., Allen, B. (eds) Atherosclerosis V. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6071-4_16
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DOI: https://doi.org/10.1007/978-1-4612-6071-4_16
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