Turnover and Metabolism of Body Cholesterol in Humans
During the past few years, kinetic studies have provided a considerable amount of information about cholesterol turnover and metabolism in intact humans. These studies have generally involved analysis of the turnover of plasma cholesterol following injection of radioactively labeled cholesterol, in experiments of about 10-12 weeks duration (Goodman and Noble 1968; Nestel et al. 1969; Goodman et al. 1973a), or of much longer duration (Samuel and Perl 1970; Goodman et al. 1973b; Samuel and Lieberman 1973; Smith et al. 1976). In 1976, we reported the results of long-term studies (32-49 weeks) of the turnover of plasma cholesterol in 8 normal and 16 hyperlipidemic subjects (Smith et al. 1976). We now report the results of similar long-term studies carried out in a total population of 54 subjects.
KeywordsCholesterol Triglyceride Washout Chol Clarification
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