Transport of Macromolecules Across the Artery Wall

  • Elspeth B. Smith
Conference paper

Abstract

Unlike most organs, arteries have two distinct characteristics: they are tubes that are subjected to external haemodynamic stresses and pulsatile bombardment with plasma constituents under pressure, and they are also metabolizing tissues that may face special problems in the supply of nutrients and oxygen and in changes in cellular environment resulting from accumulation of abnormal quantities of plasma macromolecules. In this workshop we have experts in both these areas, and I hope that this will lead to a stimulating interchange of ideas. I would like to start the discussion by considering some of the information available on transport of plasma proteins and lipoproteins into and across arterial wall.

Keywords

Arterial Wall Internal Elastic Lamina Rabbit Aorta Aortic Intima Rabbit Thoracic Aorta 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adams CWM, Virag S, Morgan RS, Orton CC (1968) Dissociation of (3-H) cholesterol and 125-I-labelled plasma protein influx in normal and atheromatous rabbit aorta. J Atheroscler Res 8: 679PubMedCrossRefGoogle Scholar
  2. Bratzler RL, Chisholm GM, Colton CK, Smith KA, Lees RS (1977) The distribution of labelled low-density lipoproteins across the rabbit thoracic aorta in vivo. Atherosclerosis 28: 289PubMedCrossRefGoogle Scholar
  3. Colton CK (1979) Transport of protein and lipid into the arterial wall. In: Wolf S, Werthessen NT (eds) Dynamics of arterial flow. Advan Exp Med Biol 115: 299Google Scholar
  4. Finkelstein JN, Ghosh S, Schweppe JS (1976) Kinetic analysis of in vivo lipo-protein flux in the normal rabbit aorta. Artery 2: 161Google Scholar
  5. Hoff HF, Heideman CL, Gotto AM, Gaubatz JW (1977) Apolipoprotein B retention in the grossly normal and atherosclerotic human aorta. Circ Res 41: 684PubMedGoogle Scholar
  6. Minick CR, Stemerman MB, Insul W (1977) Effect of regenerated endothelium on lipid accumulation in the arterial wall. Proc Natl Acad Sci USA 74: 1724PubMedCrossRefGoogle Scholar
  7. Smith EB (1974) The relationship between plasma and tissue lipids in human atherosclerosis. Advan Lipid Res 12: 1Google Scholar
  8. Smith EB, Crothers DC (1975) Interaction between plasma proteins and the intercellular matrix. In: Peeters H (ed) Protides of the Biological Fluids 22: 315 (Pergamon Press, Oxford)Google Scholar
  9. Smith EB, Slater RS (1972) Relationship between low density lipoprotein in aortic intima and serum lipid levels. Lancet 1: 463PubMedCrossRefGoogle Scholar
  10. Smith EB, Slater RS (1973) Lipids and low density lipoproteins in intima in relation to its morphological characteristics. In: Atherogenesis: Initiating factors. Ciba Foundation Symposium (New Series) 12: 39Google Scholar
  11. Smith EB, Staples EM, Dietz HS, Smith RH (1979) Role of endothelium in sequestration of lipoprotein and fibrinogen in aortic lesions, thrombi and graft pseudo-intimas. Lancet ii: 812CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1980

Authors and Affiliations

  • Elspeth B. Smith

There are no affiliations available

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