Transport of Macromolecules Across the Artery Wall
Unlike most organs, arteries have two distinct characteristics: they are tubes that are subjected to external haemodynamic stresses and pulsatile bombardment with plasma constituents under pressure, and they are also metabolizing tissues that may face special problems in the supply of nutrients and oxygen and in changes in cellular environment resulting from accumulation of abnormal quantities of plasma macromolecules. In this workshop we have experts in both these areas, and I hope that this will lead to a stimulating interchange of ideas. I would like to start the discussion by considering some of the information available on transport of plasma proteins and lipoproteins into and across arterial wall.
KeywordsArterial Wall Internal Elastic Lamina Rabbit Aorta Aortic Intima Rabbit Thoracic Aorta
Unable to display preview. Download preview PDF.
- Colton CK (1979) Transport of protein and lipid into the arterial wall. In: Wolf S, Werthessen NT (eds) Dynamics of arterial flow. Advan Exp Med Biol 115: 299Google Scholar
- Finkelstein JN, Ghosh S, Schweppe JS (1976) Kinetic analysis of in vivo lipo-protein flux in the normal rabbit aorta. Artery 2: 161Google Scholar
- Smith EB (1974) The relationship between plasma and tissue lipids in human atherosclerosis. Advan Lipid Res 12: 1Google Scholar
- Smith EB, Crothers DC (1975) Interaction between plasma proteins and the intercellular matrix. In: Peeters H (ed) Protides of the Biological Fluids 22: 315 (Pergamon Press, Oxford)Google Scholar
- Smith EB, Slater RS (1973) Lipids and low density lipoproteins in intima in relation to its morphological characteristics. In: Atherogenesis: Initiating factors. Ciba Foundation Symposium (New Series) 12: 39Google Scholar