Prothoracicotropic Hormone

  • Hironori Ishizaki
  • Akinori Suzuki
Part of the Springer Series in Experimental Entomology book series (SSEXP)


The endocrine function of the insect brain in the initiation of metamorphosis was first suggested by Kopeć as early as 1922 in the gypsy moth, Lymantria dispar. Years later, Wigglesworth (1940) clearly demonstrated that the molting of the bug Rhodnius prolixus was initiated by a hormonal factor that originated from the dorsal region of the protocerebrum containing neurosecretory cells. This brain hormone was then shown by Williams (1947, 1952) to induce molting by stimulating the prothoracic glands, which in turn secrete ecdysone in diapausing pupae of the saturniid Hylalophora cecropia. Thereafter followed numerous studies defining this hormone in a variety of insects, and it is now firmly established that the brain hormone ecdysone axis is ubiquitous in insects.


Juvenile Hormone Neurosecretory Cell Adult Development Acetone Powder Tobacco Hornworm 
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© Springer-Verlag New York Inc 1980

Authors and Affiliations

  • Hironori Ishizaki
  • Akinori Suzuki

There are no affiliations available

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