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Proteolytic Mechanisms and Pulmonary Emphysema

  • Gerard M. Turino
  • Stephen Keller
  • Tukaram V. Darnule
  • Mohamed M. Osman
  • Ines Mandl

Abstract

Pulmonary emphysema causes between 40.000 and 45.000 deaths per year in the United States. However. most people with this chronic illness. whose natural history extends over many years. are physically disabled by severe breathlessness for much of their late adult life. It is estimated that in the United States. several million people are disabled from some form of airway obstructive disease — including pulmonary emphysema (Task Force Report 1980).

Keywords

Neutrophil Elastase Chronic Obstructive Lung Disease Pulmonary Emphysema Elastase Activity Human Alveolar Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Blackwood EC, Hosannah Y, Perman E, Keller S, Mandl I (1973) Experimental emphysema in rats. Elastolytic titer of inducing 262 enzyme as determinant of response. Proc Soc Exp BioI Med 144: 450Google Scholar
  2. Boren HG (1965) Experimental emphysema. Basis, review and critique. Amer Rev Resp Dis 92: 1Google Scholar
  3. Bray BA, LeRoy EC (1976) Human alveolar basement membrane. Chemical and immunological comparisons with glomerular basement membrane and trophoblast basement membrane. Microvasc Res 12: 77-89PubMedCrossRefGoogle Scholar
  4. Campbell EJ, White RR, Senior RM, Rodriguez RJ, Kuhn C (1979) Receptor mediated binding and internalization of leucocyte elastase by alveolar macrophages in vitro. J Clin Invest 64: 824CrossRefGoogle Scholar
  5. Carp H, Janoff A (1978) Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants. Amer Rev Resp Dis 118: 617PubMedGoogle Scholar
  6. Chrzanowski PJ, Keller S, Cerreta JM, Mandl I, Turino GM (1980) Elastin content in normal and emphysematous lung. Am J Med (in press)Google Scholar
  7. Darnule TV, Likhite V, Turino GM, Mandl I (1977) Immune response to peptides produced by enzymatic digestion of microfibrils and elastin of human lung parenchyma. Conn Tissue Res 5: 67–73CrossRefGoogle Scholar
  8. Darnule TV, Likhite V, Darnule AT, Turino GM, Mandl I (1980a) Enhancement of humoral immune response against human lung elastin peptides. Experientia (in press)Google Scholar
  9. Darnule TV, Darnule AT, Likhite V, Turino GM, Mandl I (1980b) Antigenic determinants in human lung elastin peptides. Conn Tiss Res 7: 269CrossRefGoogle Scholar
  10. Darnule TV, Osman M, Darnule AT, Mandl I, Turino GM (1980c) Immunological detection of lung elastin peptides in the serum of rats with elastase induced emphysema. Amer Rev Resp Dis 121 (part 2): 331Google Scholar
  11. Eichner R, Rosenbloom J (1979) Collagen and elastin synthesis in developing chick aorta. Arch Biochem Biophys 198: 414–423PubMedCrossRefGoogle Scholar
  12. Eiseman B, Petty T, Silen W (1959) Experimental emphysema. Amer Rev Resp Dis 80 (Suppl, July): 147PubMedGoogle Scholar
  13. Eliraz A, Kimbel P, Weinbaum G (1977) Canine alveolar macrophage and neutrophil exposure to cigarette: regulation of elastase secretion. Chest 72: 259Google Scholar
  14. Fitzpatrick M (1967) Studies of human pulmonary connective tissue. Chemical changes in structural proteins with emphysema. Amer Rev Resp Dis 96: 254–265PubMedGoogle Scholar
  15. Fitzpatrick M, Hospelhorn VD (1962) Studies on human pulmonary connective tissue. 1. Amino acid composition of elastin isolated by alkaline digestion. J Lab Clin Med 60: 799PubMedGoogle Scholar
  16. Gadek JE, Fells GA, Crystal RG (1979) Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans. Science 206: 1315Google Scholar
  17. Gadek J, Humminghake G, Zimmerman R, Crystal R (1978) Mechanisms controlling release of neutrophil chemotactic factor by alveolar macrophages. Amer Rev Resp Dis 117: 65Google Scholar
  18. Galdston M, Melnick EL, Goldring RM, Levytska V, Curasi CA, Davis AL (1977) Interactions of neutrophil elastase, serum trypsin inhibitory activity and smoking history as risk factors for chronic obstructive pulmonary disease in patients with MM, MZ and ZZ phenotypes for alpha1-antitrypsin. Amer Rev Resp Dis 116: 837PubMedGoogle Scholar
  19. Green MR, Lin JS, Berman LB, Osman MM, Cerreta JM, Mandl I, Turino GM (1979) Elastolytic activity of alveolar macrophages in normal dogs and human subjects. J Lab Clin Med 94: 549PubMedGoogle Scholar
  20. Gross P, Babyak MA, Tolker E, Kaschak, M (1964) Enzymatically produced pulmonary emphysema. A preliminary report. J Occup Med 6: 481PubMedGoogle Scholar
  21. Haidak EL, Gregory JJ, Beautyman W (1950) Artificial tumors in dog bronchus and their implications in production of experimental emphysema. Proc Soc Exp BioI Med 105: 66Google Scholar
  22. Harel S, Janoff A (1980) Radioimmunoassay for desmosine: potential clinical test for elastin degradation in emphysema. Amer Rev Resp Dis 121 (part 2): 349Google Scholar
  23. Hinman LM, Stevens CA, Matthay RA, Gee JBL (1980) Elastase and lysozyme activities in human alveolar macrophages. Am Rev Resp Dis 121: 263PubMedGoogle Scholar
  24. Janoff A (1970) Mediators of tissue damage in the leukocyte lysosomes. X. Further studies on human granulocyte elastase. Lab Invest 22: 228PubMedGoogle Scholar
  25. Janoff A, Carp H, Lee DK (1979) Cigarette smoke inhalation decreases alphacantitrypsin activity in rat lung. Science 206: 1313PubMedCrossRefGoogle Scholar
  26. Janoff A, Sandhaus RA, Hospelhorn V D , Rosenberg R (1972) Digestion of lung proteins by human leucocyte granules in vitro. Proc Soc Exp BioI Med 140: 516Google Scholar
  27. Janoff A, Scherer J (1968) Mediators of inflammation in leukocyte lysosomes. IX Elastinolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 128: 1137PubMedCrossRefGoogle Scholar
  28. Johanson WG Jr, Pierce AK (1972) Effects of elastase, collagenase and papain on structure and function of rat lungs in vitro. J Clin Invest 51: 288–293PubMedCrossRefGoogle Scholar
  29. Kaplan PD, Kuhn C, Pierce JA (1973) The induction of emphysema with elastase. 1. The evolution of the lesion and the influence of serum. J Lab CUn Med 82: 349Google Scholar
  30. Karlinsky JB, Snider GL, Franzblau C, Stone PJ, Hoppin FG (1976) In vitro effects of elastase and collagenase of mechanical properties of hamster lungs. Amer Rev Resp Dis 113:769PubMedGoogle Scholar
  31. Keller S, Mandl I, Turino GM (1980) Determination of the relative amounts of elastin in lung tissues. (submitted for publication)Google Scholar
  32. King GS, Mohan VS, Starcher BC (1980) Radioimmunoassay for desmosine. Conn Tiss Res 7: 263CrossRefGoogle Scholar
  33. Kucich U, Christner P, Rosenbloom J, Weinbaum G (1980) An analysis of the organ and species immunospecificity of elastin. Conn Tiss Res (in press)Google Scholar
  34. Kuhn C, Yo S-Y, Chraplyvy M, Linder HE, Senior RM (1976) The induction of emphysema with elastase. II. Changes in connective tissue. Lab Invest 34: 372–380PubMedGoogle Scholar
  35. Laennec RTH (1826) Traite de L'Auscultation Mediate, 2 ed, JJ Chaude, ParisGoogle Scholar
  36. Laurell CB, Eriksson S (1963) The electrophoretic alpha1-globulin pattern of serum in alpha1-antitrypsin deficiency. Scand J Clin Lab Invest 15: 132Google Scholar
  37. Lavie G, Zucker-Franklin 0, Franklin E (1980) Elastase-type proteases on the surface of human blood monocytes: possible role in amyloid formation. J Immunol 125: 175PubMedGoogle Scholar
  38. Lowry 0 H, Gilligan DR, Katersky EM (1941) The determination of collagen and elastin in tissues with results obtained in various normal tissues from different species. J BioI Chern 139: 795Google Scholar
  39. Mandl I, Darnule TV, Fierer JA, Keller S, Turino GM (1977) Elastin degradation in human and experimental emphysema. In: Sandberg LB, Gray WR, Franzblau C (eds) Elastin and elastic tissue. Plenum Press, New YorkGoogle Scholar
  40. Marco V, Mass B, Meranze DR, Weinbaum G, Kimbel P (1971) Induction of experimental emphysema in dogs using leukocyte homogenates. Amer Rev Resp Dis 104: 595PubMedGoogle Scholar
  41. McDonald JA, Baum BJ, Rosenberg OM, Kelman JA, Brin SC, Crystal RG (1979) Destruction of a major extracellular adhesive glycoprotein (fibronectin) of human fibroblasts by neutral proteases from polymorphonuclear leucocyte granules. Lab Invest 40: 350Google Scholar
  42. Ohlsson U, Ohlsson I (1974) The neutral proteases of human granUlocyte elastases. Eur J Biochem 42: 519PubMedCrossRefGoogle Scholar
  43. Osman M, Leuenberger P, Cerreta J, Keller S, Mandl I, Turino GM (1980) Pulmonary elastin content in dogs with papain induced emphysema. Proc Soc Exp BioI Med (in press)Google Scholar
  44. Pecora LJ, Manne WR, Baum GL, Feldman DP, Recavarren J (1967) Biochemical study of ground sUbstances in normal and emphysematous lungs. Amer Rev Resp Dis 95: 623–630PubMedGoogle Scholar
  45. Pierce J A, Hoeott JB (1960) Studies on the collagen and elastin content of human lungs. J Clin Invest 39: 8PubMedCrossRefGoogle Scholar
  46. Pierce JA, Hocott JB, Ebert RV (1961) The collagen and elastin content of lung in emphysema. Ann Int Med 55: 210–221PubMedGoogle Scholar
  47. Ragsdale CG, Arend WP (1979) Neutral protease secretion by human monocytes — effect of surface bound immune complexes. J Exp Med 149: 954PubMedCrossRefGoogle Scholar
  48. Rodriguez JR, Seals JE, Radin A, Lin JS, Mandl I, Turino GM (1979) Neutrophil lysosomal elastase activity in normal subjects and in patients with chronic obstructive pulmonary disease. Amer Rev Resp Dis 119: 409Google Scholar
  49. Rodriguez RJ, White RR, Senior RM, Levine EA (1977) Elastase release from human alveolar macrophages: comparison between smokers and nonsmokers. Science 198: 313–314PubMedCrossRefGoogle Scholar
  50. Rohrer F (1915) Der Stromungswiderstand in den menschlichen Atemwegen und der Einfluss der unregelmassigen Verzweigung des Bronchial-systems auf den Atmungsverlauf in verschiedenen Lungenbezirken. Pflueger Arch ges Physiol 162: 225–299CrossRefGoogle Scholar
  51. Scarselli V, Repetto M (1959) The elastin content of lung in relation to age. Ital J Biochem 8: 169Google Scholar
  52. Senior RM, Ladis JA, Campbell EJ, Koren HS (1980) Elastase activity associated with a human macrophage-like cell line. Clin Res 28: 531AGoogle Scholar
  53. Snider GL, Korthy AL (1978) Internal surface area and number of respiratory air spaces in elastase induced emphysema in hamsters. Amer Rev Resp Dis 117: 685PubMedGoogle Scholar
  54. Snider GL, Sherter CB (1977) A one year study of the evolution of elastase induced emphysema in hamsters. J Appl Physiol Respir Environ Exercise Physiol 43: 721Google Scholar
  55. Snider G L, Sherter CB, Koo KW, Karlinsky JB, Hayes J A, Franzblau C (1977) Respiratory mechanics in hamsters following treatment with endotracheal. elastase or collagenase. J Appl Physiol 42: 206PubMedGoogle Scholar
  56. Task Force Report: Epidemiology of Respiratory Diseases (July 1979) Dept. of Health and Human Services, Publication NIH Publication #81-2019 - October 1980Google Scholar
  57. Turino GM, Goldring RM, Katz LA (1961) The effect of experimental bronchomalacia on pulmonary mechanics. J Clin Invest 40: 1086Google Scholar
  58. Turino GM, Lourenco RV (1972) The connective tissue basis of pulmonary mechanics. In: Mitman C (ed) Pulmonary emphysema and proteolysis. Academic Press, New York, p. 59Google Scholar
  59. Turino GM, Lourenco RV, McCracken GH (1964) The role of connective tissue in pulmonary mechanics. J Clin Invest 43: 1297Google Scholar
  60. Turino GM, Lourenco RV, McCracken GH (1968) Role of connective tissue in large pulmonary airways. J Appl Physiol 25: 645PubMedGoogle Scholar
  61. Weinbaum G, Sloan B, Meranze DR, Kimbel P (1978) A model of experimental emphysema using a completely homologous system. Amer Rev Resp Dis 117: 411Google Scholar
  62. Werb Z, Gordon S (1975) Elastase secretion by stimulated macrophages. J Exp Med 142: 361PubMedCrossRefGoogle Scholar
  63. WHO Techn Rep Ser (1961) No. 213, 15 Report of an expert committee on chronic cor pulmonaleGoogle Scholar
  64. Wright GW, Kleinerman J, Zorn EM (1960) The elastin and collagen content of normal and emphysematous human lungs (abstract). Am Rev Respir Dis 81: 938Google Scholar
  65. Wright RR (1961) Elastic tissue of normal and emphysematous lungs. A tridimensional histologic study. Am J Path 39: 355–368PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1981

Authors and Affiliations

  • Gerard M. Turino
  • Stephen Keller
  • Tukaram V. Darnule
  • Mohamed M. Osman
  • Ines Mandl

There are no affiliations available

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