Skip to main content
SpringerLink
Log in

Biochemistry of Collagen with Special Reference to the Arterial Wall

  • Chapter
Connective Tissues in Arterial and Pulmonary Disease

  • 49 Accesses

Abstract

Investigations of the last decade have produced major advances in collagen biochemistry (for reviews see Bornstein and Sage 1980; Bornstein and Traub 1979; Eyre 1980; Prockop et al. 1979; Miller and Gay, in press). Among the most significant has been the discovery of the genetically distinct collagens that spawned numerous studies concerning the characterization and distribution of the various collagen types. Such studies have also begun to elucidate .some of the roles collagen can play in both normal and pathologic conditions (Gay and Miller 1978).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Barnes MJ, Morton LF, Levene CI (1976) Synthesis of collagen types I and III by pig medial smooth muscle cells in culture. Biochem Biophys Res Commun 70: 339

    Article  PubMed  CAS  Google Scholar 

  • Benditt EP (1977) The origin of atherosclerosis. Sci Am 236: 74

    Google Scholar 

  • Bentz H, Bachinger HP, Glanville R, Kuhn K (1978) Physical evidence for the assembly of A and B chains of human placental collagen in a single triple helix. Europ Biochem 92: 563

    Article  CAS  Google Scholar 

  • Bornstein P, Sage H (1980) Structurally distinct collagen types.An Rev Biochem 49: 957

    Article  CAS  Google Scholar 

  • Bornstein P, Traub W (1979) The chemistry and biology of collagen.In: Neurath H, Hill RL (eds) The Proteins, Vol IV.Academic Press, New York

    Google Scholar 

  • Brown RA, Shuttleworth CA, Weiss JB (1978) Three new a-chains of collagen from a non-basement membrane source. Biochem Biophys Res Commun 80: 866

    Article  PubMed  CAS  Google Scholar 

  • Burgeson RE, El Adli FA, KaitilaII, Hollister OW (1976) Fetal membrane collagens: Identification of two new collagen alpha chains. Proc Natl Aca Sci USA 73: 2579

    Article  CAS  Google Scholar 

  • Burke JM, Bailan G. Ross R. Bornstein P (1977) Synthesis of types I and III procollagen by monkey aortic smooth muscle cells in vitro. Biochemistry 16: 3243

    Article  PubMed  CAS  Google Scholar 

  • Chung E, Miller EJ (1974) Collagen polymorphism: Characterization of molecules with the chain composition [a1(III)]3 in human tissues. Science 183: 1200

    CAS  Google Scholar 

  • Chung E, Keele EM. Miller EJ (1974) Isolation and characterization of the cyanogen bromide peptides from the al(III) chain of human collagen. Biochemistry 13: 3459

    Article  PubMed  CAS  Google Scholar 

  • Chung E, Rhodes RK. Miller EJ (1976) Isolation of three collagenous components of probable basement membrane origin from several tissues.Biochem Biophys Res Commun 71: 1167

    Article  PubMed  CAS  Google Scholar 

  • Crouch E, Bornstein P (1978) Collagen synthesized by human amniotic fluid cells in culture: Characterization of a procollagen with three identical pro al(1) chains. Biochemistry 17: 5499

    Google Scholar 

  • Crouch E, Sage H, Bornstein P (1980) Structural basis for apparent heterogeneity of collagens in human basement membranes: Type IV procoUagen contains two distinct chains. Proc Natl Aca Sci USA 77: 745

    Article  CAS  Google Scholar 

  • Dixit SN (1979) Isolation and characterization of two a-chain size collagenous polypeptide chains C and D from glomerular basement membrane. FEBS Letters 106: 379

    Article  PubMed  CAS  Google Scholar 

  • Eyre DR (1980) Collagen: Molecular diversity in the body’s protein scaffold. Science 207: 1315

    PubMed  CAS  Google Scholar 

  • Furuto DK, Miller EJ (1980) Isolation of a unique collagenous fraction from limited pepsin digests of human placental tissue. Biol Chern 255: 290

    CAS  Google Scholar 

  • Gay S, Miller EJ (1978) Collagen in the Physiology and Pathology of Connective Tissue. Gustav Fischer, Stuttgart-New York

    Google Scholar 

  • Gay S, Miller EJ (1979) Characterization of lens capsule collagen: evidence for the presence of two unique chains in molecules derived from major basement membrane structures. Archiv Biochem Biophys 198: 370

    Article  CAS  Google Scholar 

  • Gay S, Balleisen L, Remberger K, Fietzek PP, Adelmann BC, Kuhn K (1975) Immunohistochemical evidence for the presence of collagen type III in human arterial walls, arterial thrombi, and in leucocytes, incubated with collagen in vitro. Klin Worchensch 53: 899

    Article  CAS  Google Scholar 

  • Gay S, Kresina TF, Gay R, Miller EJ, Montes LF (1979) Immunohistochemical demonstration of basement membrane collagen in normal human skin and in psoriasis. Cutaneous Pathol 6: 91

    Article  CAS  Google Scholar 

  • Glanville RW, Rauter A, Fietzek PP (1979) Isolation and characterization of a native placental basement-membrane collagen and its component chains. Europ Biochem 95: 383

    Article  CAS  Google Scholar 

  • Haralson MA, Mitchell WM, Rhodes RK, Kresina TF, Gay R, Miller EJ (1980) Chinese hamster lung cells synthesize and confine to the cellular domain a collagen comprised soley of B chains. Proc Natl Aca Sci USA in press

    Google Scholar 

  • Howard BV, Macarak EJ, Gunson D, Kefalides NA (1976) Characterization of the collagen synthesized by endothelial cells in culture. Proc Natl Aca Sci USA 73: 2361

    Article  CAS  Google Scholar 

  • Jaffe EA, Minick CR, Adelman B, Becker CG, Nachman R (1976) Synthesis of basement membrane collagen by cultured human endothelial cells. Exper Med 144: 209

    Article  CAS  Google Scholar 

  • Kresina TF, Miller EJ (1979) Isolation and characterization of basement membrane collagen from human placental tissue. Evidence for the presence of two genetically-distinct collagen chains. Biochemistry 18: 3089

    Article  PubMed  CAS  Google Scholar 

  • Layman DL, Epstein EJ, Dodson RF, Titus JL (1977) Biothesis of type I and III collagens by cultured smooth muscle cells from human aorta. Proc Natl Aca Sci USA 74: 671

    Article  CAS  Google Scholar 

  • Martin GM, Sprague CA (1973) Symposium on in vitro studies related to atherogenesis: Life histories of hyperplastoid cell lines from aorta and skin. Exper Mole Pathol 18: 125

    Article  CAS  Google Scholar 

  • Mayne R, Vail MS, Miller EJ (1975) Analysis of changes in collagen biosynthesis that occur when chick chondrocytes are grown in 5-bromo-2'-deoxyuridine. Proc Natl Aca Sci USA 72: 4511

    Article  CAS  Google Scholar 

  • Mayne R, Vail MS, Miller EJ, Blose SH, Chacko S (1977) Collagen polymorphisms in cell cultures derived from guinea pig aortic smooth muscle: Comparison with three populations of fibroblasts. Archiv Biochem Biophys 181: 462

    Article  CAS  Google Scholar 

  • Mayne R, Vail MS, Miller EJ (1978) Characterization of the collagen chains synthesized by cultured smooth muscle cells derived from rhesus monkey thoracic aorta. Biochemistry 17: 446

    Article  PubMed  CAS  Google Scholar 

  • McCullagh KA, Balian G (1975) Collagen characterization and cell transformation in human atherosclerosis. Nature 258: 73

    Article  PubMed  CAS  Google Scholar 

  • Miller EJ(1971) Isolation and characterization of a collagen from chick cartilage containing three identical a chains. Biochemistry 10: 1652

    Article  PubMed  CAS  Google Scholar 

  • Miller EJ (1976) Biochemical characteristics and biological significance of the genetically-distinct collagens. Molec Cell Biochem 13: 165

    Article  PubMed  CAS  Google Scholar 

  • Miller EJ, Gay S (in press) The multiple types and forms of collagen-an overview. In: Cunningham LW, Fredericksen D W (eds) Methods in Enzymology. Academic Press, New York

    Google Scholar 

  • Munksgaard EC, Rhodes M, Mayne R, Butler WT (1978) Collagen synthesis and secretion by rat incisor odontoblasts in organ culture. Europ Biochem 82: 609

    Article  CAS  Google Scholar 

  • Narayanan AS, Page RC, Kuzan F (1978) Collagens synthesized in vitro by diploid fibroblasts obtained from chronically inflamed human connective tissue. Lab Inves 39: 61

    CAS  Google Scholar 

  • Prockop DJ, Kivirikko KI, Tuderman L, Guzman NA (1979) The biosynthesis of collagen and its disorders. N Eng J Med 301: 77

    Article  CAS  Google Scholar 

  • Rauterberg J, Allam S, Brehmer U, Wirth W, Hauss WH (1977) Characterization of the collagen synthesized by cultured human smooth muscle cells from fetal and adult aorta. HoppeSeyler&3x2019;s Zeitshr Physio Chern 358: 401

    Article  CAS  Google Scholar 

  • Rhodes RK, Miller EJ (1978) Physico-chemical characterization and molecular organization of the collagen A and B chains. Biochemistry 17: 3442

    Article  PubMed  CAS  Google Scholar 

  • Ross R, Glomset JA (1976) The pathogenesis of atherosclerosis. N Eng J Med 295: 420

    Article  CAS  Google Scholar 

  • Sage H, Bornstein P (1979) Characterization of a novel collagen chain in human placenta and its relation to AB collagen. Biochemistry 18: 3815

    Article  PubMed  CAS  Google Scholar 

  • Sage H, Crouch E, Bornstein P (1979a) Collagen synthesis by bovine aortic endothelial cells in culture. Biochemistry 18: 5433

    Article  PubMed  CAS  Google Scholar 

  • Sage H, Wordbury RG, Bornstein P (1979b) Structural studies on human type IV collagen. J Biol Chern 254: 9893

    CAS  Google Scholar 

  • Scott DM, Harwood R, Grant ME, Jackson DS (1977) Characterization of the major collagen species present in procine aortae and the synthesis of their precursors by smooth muscle cells in culture. Connective Tissue Res 5: 7

    Article  CAS  Google Scholar 

  • Smith GN Jr, Linsenmayer TF, Newsome DA (1976) Synthesis of type II collagen in vitro by embryonic chick neural retina tissue. Proc Nati Aca Sci USA 73: 4420

    Article  CAS  Google Scholar 

  • Timpl R, Martin GR, Bruckner P, Wick G, Wiedemann H (1978) Nature of the collagenous protein in a tumor basement membrane. Europ J Biochem 84: 43

    Article  PubMed  CAS  Google Scholar 

  • Trelstad RL, Kang AH, Igarashi S, Gross J (1970) Isolation of two distinct collagens from chick cartilage. Biochemistry 9: 4993

    Article  PubMed  CAS  Google Scholar 

  • Uitto J (1979) Collagen polymorphism: isolation and partial characterization of a1(I)-trimer molecules in normal human skin. Archiv Biochem Biophys 192: 371

    Article  CAS  Google Scholar 

  • Wohllebe M, Carmichael DJ (1978) Type-I-trimer and type-I collagen in neutral-salt-soluble lathyritic-rat dentine. Europ JBiochem 92: 183

    Article  CAS  Google Scholar 

Download references

Authors
  1. R. Kent Rhodes
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. School of Medicine, Medical College of Georgia, Augusta, Georgia, 30912, USA

    Thomas F. McDonald Ph.D. (Professor of Anatomy, Associate Dean for Basic Sciences) (Professor of Anatomy, Associate Dean for Basic Sciences)

  2. Department of Pathology, School of Medicine, Medical College of Georgia, Augusta, Georgia, 30912, USA

    A. Bleakley Chandler M.D. (Professor of Pathology, Chairman) (Professor of Pathology, Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Rhodes, R.K. (1981). Biochemistry of Collagen with Special Reference to the Arterial Wall. In: McDonald, T.F., Chandler, A.B. (eds) Connective Tissues in Arterial and Pulmonary Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5967-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-5967-1_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5969-5

  • Online ISBN: 978-1-4612-5967-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation