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Endothelial Injury in Hypertension

  • Stephen M. Schwartz
  • Donna M. Standaert

Abstract

There are attractive reasons for considering the possibility that platelet mitogen released at sites of endothelial denudation accounts for the smooth muscle cell proliferation found in arteriosclerosis of hypertensive large and small arteries (1–3). The first question in this research is whether endothelial injury occurs. Endothelial injury is well documented in acute renal hypertension (4), and a number of studies have tried to identify a direct toxic effect of angiotensin II (5–8). This is supported by evidence that vasoactive agents are capable of opening cell junctions of postcapillary venular endothelium (9). This effect, however, is specific for these vessels and may relate to the incomplete junctional complexes seen only in the postcapillary venular endothelium (10). There have been reports that angiotensin II has a similar effect on the arterial endothelium. This effect is said to occur under conditions of normal or low blood pressure—thus suggesting a direct effect on endothelial contractility (7).

Keywords

Endothelial Injury Chronic Hypertension Acute Hypertension Hypertension Detection Aortic Intima 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Thorgeirsson G, Robertson AL (1978) The vascular endothelium: Pathobiologic significance. Am J Path 93: 804–848Google Scholar
  2. 2.
    Schwartz SM (1977) Hypertension, endothelial injury and atherosclerosis. Cardiovasc Med 2: 10: 991–1002Google Scholar
  3. 3.
    Ross R, Vogel A (1978) The platelet-derived growth factor. Cell 14: 203–210PubMedCrossRefGoogle Scholar
  4. 4.
    Fernandez D, Crane WAJ (1970) New cell formation in rats with accelerated hypertension due to partial aortic constriction. J Pathol 100: 307–316PubMedCrossRefGoogle Scholar
  5. 5.
    Goldby FS, Beilin LJ (1972) Relationship between arterial pressure and the permeability of arterioles to carbon particles in acute hypertension in the rat. Cardiovasc Res 6: 384–390PubMedCrossRefGoogle Scholar
  6. 6.
    Goldby FS, Beilin LJ (1972) How an acute rise in arterial pressure damages arterioles: Electron microscopic changes during angiotensin infusion. Cardiovasc Res 6: 569–584PubMedCrossRefGoogle Scholar
  7. 7.
    Robertson AL, Khairallah PA (1973) Arterial endothelial permeability and vascular disease: The “trap door” effect. Exp Mol Pathol 18: 241–260PubMedCrossRefGoogle Scholar
  8. 8.
    Giese J (1973) Renin, angiotensin and hypertensive vascular damage: A review. Am J Med 55: 315–332PubMedCrossRefGoogle Scholar
  9. 9.
    Majno G (1965) Ultrastructure of the vascular membrane. In: Hamilton WF, Dow P (eds) American Physiological Society—Handbook of physiology, Sect 2, Vol 3: Circulation. Williams & Wilkins, Baltimore, Md, pp 2293–2375Google Scholar
  10. 10.
    Simionescu N, Simionescu M, Palade GE (1978) Structural basis of permeability in sequential segments of the micro vasculature of the diaphragm: I. Bipolar microvascular fields. Microvasc Res 15: 1–16PubMedCrossRefGoogle Scholar
  11. 11.
    Gabbiani G, Elemer G, Guelpa C, Vallotton MB, Badonnel M-C, Hiittner J (1979) Morphologic and functional changes of the aortic intima during experimental hypertension. Am J Pathol 96: 399–423PubMedGoogle Scholar
  12. 12.
    Greditzer HG, Fischer VW (1978) A sequential ultrastructural study of different arteries in the hypertensive rat. Exp Mol Pathol 29: 12–28PubMedCrossRefGoogle Scholar
  13. 13.
    Todd ME, Friedman SM (1972) The ultrastructure of peripheral arteries during development of DOCA hypertension in the rat. Z Zellforsch Mikrosk Anat 128: 538–554PubMedCrossRefGoogle Scholar
  14. 14.
    Giacomelli F, Rooney J, Wiener J (1978) Cerebrovascular ultrastructure and permeability after carotid artery constriction in experimental hypertension. Exp Mol Pathol 28: 309–321PubMedCrossRefGoogle Scholar
  15. 15.
    Suzuki K, Ookawara S, Ooneda G (1971) Increased permeability of the arteries in hypertensive rats: An electron microscopic study. Exp Mol Pathol 15: 198–208PubMedCrossRefGoogle Scholar
  16. 16.
    Schwartz SM, Benditt EP (1977) Aortic endothelial cell replication: I. Effects of age and hypertension in the rat. Circ Res 41: 248–255PubMedGoogle Scholar
  17. 17.
    Hladovec J (1978) Circulating endothelial cells as a sign of vessel wall lesions. Physiol Bohemoslov 27: 140–144PubMedGoogle Scholar
  18. 18.
    Reidy MA, SChwartz SM (in press) Mechanism of endothelial repair after injury. Fed ProcGoogle Scholar
  19. 19.
    Hypertension Detection and Follow-up Program Cooperative group (1979) Five-year findings of the hypertension detection and follow-up program: I. Reduction in mortality of persons with high blood pressure, including mild hypertension. JAMA 242: 2562–2571CrossRefGoogle Scholar
  20. 20.
    Wolinsky H (1970) Response of the rat aorta media to hypertension: Morphological and chemical studies. Circ Res 26: 507–522PubMedGoogle Scholar
  21. 21.
    Bevan RD (1976) An autoradiographic and pathologic study of cellular proliferation in rabbit arteries correlated with an increase in arterial pressure. Blood Vessels 13: 100–128PubMedGoogle Scholar
  22. 22.
    Limas C, Westrum B, Limas C (1980) The evolution of vascular changes in the spontaneously hypertensive rat. Am J Pathol 98: 357–385PubMedGoogle Scholar
  23. 23.
    Haudenschild CC, Prescott MF, Chobanian AV (1980) Effects of hypertension and its reversal in aortic intima lesions of the rat. Hypertension 2: 33–44PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • Stephen M. Schwartz
  • Donna M. Standaert

There are no affiliations available

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