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Position Paper: Hypertension Mechanisms in Experimental Animals and Their Relevance to Humans

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Frontiers in Hypertension Research

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Abstract

Sodium intake and Na balance play an important role in human essential hypertension. The evidence for this comes from various directions. Diets very low in Na content can lower the blood pressure of hypertension subjects (1). Such diets slightly reduce body Na. Thiazides, acting as natriuretic agents, also lower blood pressure, probably through the same mechanism. Such drugs also slightly reduce body Na. Moreover, a high-salt intake of 20 g daily can drown out the antihypertensive effect of these diuretic agents (2).

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Authors
  1. Louis Tobian
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Editor information

Editors and Affiliations

  1. Cardiovascular Center, Division of Cardiology, The New York Hospital—Cornell Medical Center, 525 East 68th Street, 10021, New York, New York, USA

    John H. Laragh M.D. (Hilda Altshul Master Professor of Medicine Director, Chief) (Hilda Altshul Master Professor of Medicine Director, Chief)

  2. Department of Medicine and Department of Research, University Hospital, 4031, Basel, Switzerland

    Fritz R. Bühler M.D. (Associate Professor of Medicine Director of Hypertension Unit Consultant in Cardiology) (Associate Professor of Medicine Director of Hypertension Unit Consultant in Cardiology)

  3. University of Texas Health Science Center at Dallas, Dallas, Texas, 75216, USA

    Donald W. Seldin M.D., M.A.C.P. (William Buchanan Professor of Medicine Chairman of External Medicine Chief of Medical Service) (William Buchanan Professor of Medicine Chairman of External Medicine Chief of Medical Service)

  4. Parkland Memorial Hospital, Dallas, Texas, 75216, USA

    Donald W. Seldin M.D., M.A.C.P. (William Buchanan Professor of Medicine Chairman of External Medicine Chief of Medical Service) (William Buchanan Professor of Medicine Chairman of External Medicine Chief of Medical Service)

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© 1981 Springer-Verlag New York Inc.

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Tobian, L. (1981). Position Paper: Hypertension Mechanisms in Experimental Animals and Their Relevance to Humans. In: Laragh, J.H., Bühler, F.R., Seldin, D.W. (eds) Frontiers in Hypertension Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5899-5_62

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  • DOI: https://doi.org/10.1007/978-1-4612-5899-5_62

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5901-5

  • Online ISBN: 978-1-4612-5899-5

  • eBook Packages: Springer Book Archive

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