Abstract
The mechanisms responsible for the differences in renin secretion among the renin subgroups of essential hypertension are controversial (1). None of the theories proposed to explain renin suppression in patients with low-renin hypertension has received general consent (2, 3); on the other hand, high-renin levels, which were originally attributed to severe vascular damage of the kidneys (4), are often present even in young patients with mild, uncomplicated, essential hypertension (5). Also, the hypothesis of Esler et al. (5, 6) that the high- and low-renin levels of renin may reflect, respectively, a hyper- and hypoadrenergic activity, has been recently denied by other investigators (7, 8).
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References
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Morganti, A., Pickering, T.G., Lopez-Ovejero, J.A., Laragh, J.H. (1981). Renin Responsiveness to Neural and Nonneural-Mediated Stimuli in the Renin Subgroups of Essential Hypertension. In: Laragh, J.H., Bühler, F.R., Seldin, D.W. (eds) Frontiers in Hypertension Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5899-5_42
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DOI: https://doi.org/10.1007/978-1-4612-5899-5_42
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