Renin Responsiveness to Neural and Nonneural-Mediated Stimuli in the Renin Subgroups of Essential Hypertension

  • Alberto Morganti
  • Thomas G. Pickering
  • Jorge A. Lopez-Ovejero
  • John H. Laragh
Conference paper


The mechanisms responsible for the differences in renin secretion among the renin subgroups of essential hypertension are controversial (1). None of the theories proposed to explain renin suppression in patients with low-renin hypertension has received general consent (2, 3); on the other hand, high-renin levels, which were originally attributed to severe vascular damage of the kidneys (4), are often present even in young patients with mild, uncomplicated, essential hypertension (5). Also, the hypothesis of Esler et al. (5, 6) that the high- and low-renin levels of renin may reflect, respectively, a hyper- and hypoadrenergic activity, has been recently denied by other investigators (7, 8).


Essential Hypertension Plasma Renin Activity Sodium Intake Plasma Norepinephrine Plasma Catecholamine 
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  1. 1.
    Mitchell JR, Taylor AA, Pool JL, Lake CR, Rollins DE, Bartter FC (1977) NIH conference: Renin-aldosterone profiling in hypertension. Ann Intern Med 87: 596–612Google Scholar
  2. 2.
    Dunn MJ, Tannen RL (1974) Low renin hypertension. Kid Int 5: 317–325CrossRefGoogle Scholar
  3. 3.
    Ganguly A, Weinberger M (1979) Low renin hyper-tension: A current review of definitions and controversies. Am Heart J 98: 642–652PubMedCrossRefGoogle Scholar
  4. 4.
    Brunner HR, Laragh JH, Baer L, Newton MA, Goodwin FT, Krakoff LR, Bard HR, Buhler FR (1972) Essential hypertension: Renin and aldosterone, heart attack and stroke. New Engl J Med 286: 441–449PubMedCrossRefGoogle Scholar
  5. 5.
    Esler M, Julius J, Zweigler A, Randall O, Harburg E, Gardiner H, DeQuattro V (1977) Mild high-renin essential hypertension. New Engl J Med 296: 405–411PubMedCrossRefGoogle Scholar
  6. 6.
    Esler M, Randall O, Bennet J, Zweigler A, Julius S, Rydeleck P (1976) Suppression of sympathetic nervous function in low renin essential hypertension. Lancet 2: 115–118PubMedCrossRefGoogle Scholar
  7. 7.
    Taylor AA, Pool JL, Lake RC, Ziegler MG, Rosen AA, Rollins DE, Mitchell JR (1978) Plasma norepinephrine concentrations: No differences among normal volunteers and low, high or normal renin hypertensive patients. Life Sci 22: 1499–1510PubMedCrossRefGoogle Scholar
  8. 8.
    Buhler FR, Bertel O, Kiowski DW (1978) Plasma noradrenaline and adrenaline and -adrenoreceptor responsiveness in renin subgroups of essential hypertension. Clin Sci Mol Med 55: 57S–60SGoogle Scholar
  9. 9.
    Passon PG, Peuler JD (1973) A simplified radiometric assay for plasma norepinephrine and epinephrine. Ann Biochem 51: 618–631CrossRefGoogle Scholar
  10. 10.
    Sealey JE, Laragh JH (1977) How to do a plasma renin assay. Cardiovasc Med 2: 1079–1092Google Scholar
  11. 11.
    Morganti A, Lopez-Ovejero JA, Pickering TG, Laragh JH (1979) The role of the sympathetic nervous system in mediating the renin response to head up tilt and their possible synergism in defending blood pressure against postural changes during sodium deprivation. Am J Cardiol 43: 600–604PubMedCrossRefGoogle Scholar
  12. 12.
    Bravo EL, Tarazi RC, Dustan HP (1974) On the mechanism of suppressed plasma renin activity during beta-adrenergic blockade with propranolol. J Lab Clin Med 83: 119–128PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • Alberto Morganti
  • Thomas G. Pickering
  • Jorge A. Lopez-Ovejero
  • John H. Laragh

There are no affiliations available

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