Skip to main content

Oxygen in Closed Environmental Systems

  • Conference paper

Part of the book series: Topics in Environmental Physiology and Medicine ((TEPHY))

Abstract

The normal concentration of oxygen in air is approximately 21%, corresponding to a partial pressure of 0.21 ATA (Atmosphere Absolute) or 159 mm Hg. In closed systems such as pressure chambers, air craft or space craft, the partial pressure of oxygen may become increased and result in oxygen toxicity. On the other hand, there are situations in which a lowering of oxygen partial pressure may occur in all these systems, causing symptoms of anoxia.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alella, A., Meda, E. (1948). Frequenza cardiaca durante la respirazioni di O2 nell’ uomoed importanza del vago. EnBoll. Soc. Ital. Biol. Sper.En 24: 581.

    CAS  Google Scholar 

  • Asmussen, E., Nielsen, M. (1947). Studies in the regulation of respiration in heavy work. EnActa Physiol. Scand.En 12: 121.

    Google Scholar 

  • Baker, S. P., Hitchcock, F. A. (1957). Immediate effects of inhalation of 100% oxygen at one atmosphere on ventilation volume, carbon dioxide output, oxygen consumption and respiratory rate in man. EnJ. Appl. Physiol.En 10: 363–366.

    PubMed  CAS  Google Scholar 

  • Bean, J. W. (1945). Effects of oxygen at increased pressure. EnPhysiol. Rev.En 25: 1–147.

    CAS  Google Scholar 

  • Bean, J. W., Rottschafer, G. (1938). Reflexogenic and central structures in oxygen poisoning. EnJ. PhysiolEn. (London) 94: 294–306.

    CAS  Google Scholar 

  • Bean, J. W. (1961). Tris buffer, carbon dioxide, and sympathico-adrenal system in reactions to oxygen at high pressure. EnAm. J. Physiol.En 201: 737–739.

    PubMed  CAS  Google Scholar 

  • Bean, J. W., Zee, D. (1966). Influence of anesthesia and carbon dioxide on CNS and pulmonary effects of oxygen at high pressure. EnJ. Appl. Physiol.En 21: 521–526.

    PubMed  CAS  Google Scholar 

  • Behnke, A. R., Johnson, F. S., Poppen, J. R, Motley, E. P. (1934–1935). The effect of oxygen on man at pressures from 1 to 4 atmospheres. EnAm. J. Physiol.En 110: 565–572.

    Google Scholar 

  • Behnke, A. R., Forbes, H. S., Motley, E. P. (1935–1936). Circulatory and visual effects of oxygen at 3 atmospheres pressure. EnAm. J. Physiol.En 114: 436–442.

    CAS  Google Scholar 

  • Benedict, F. G., Higgins, H. L. (1911). Effects on men at rest of breathing oxygen-rich gas mixtures. Am. J. Physiol. 28:1–28. Bert, P. (1878). La Pression barométrique, recherches de physiologie expérimentale. Paris Masson; 1168 pp. (English translation: Barometric Pressure. Researches in Experimental Physiology, translated by M. A. Hitchcock F. A. Hitchcock. 1943. Columbus, Ohio: College Book Co., 1055 pp.)

    CAS  Google Scholar 

  • Block, E. R., Fisher, A. B. (1977). Depres-sion of serotonin clearance by rat lungs during oxygen exposure. EnJ. Appl. Physiol.En 42: 33–38.

    PubMed  CAS  Google Scholar 

  • Brooksby, G. A., Dennis, R. L., Staley, R. W. (1966). Effects of prolonged exposure of rats to increased oxygen pressure. Proceedings of the Third International Conference on Hyperbaric Medicine. Eds., I. W. Brown, B. G. Cox. Nat. Acad. Sci. Publ. 1404, pp. 208–216.

    Google Scholar 

  • Chance, B., Jamieson, D., Coles, H. (1965). Energy-linked pyridine nucleotide reduction: Inhibitory effects of hyperbaric oxygen in vitro in vivo. Nature 206: 257–263.

    Article  PubMed  CAS  Google Scholar 

  • Chance, B., Jamieson, D., Williamson, J. R. (1966). Control of the oxidation-reduction state of reduced pyridine nucleotides in vivo and in vitro by hyperbaric oxygen. In: Proceedings of the Third International Conference on Hyperbaric Medicine. Eds., I. W. Brown and B.G. Cox. Washington, D. C.: National Academy of Sciences, pp. 15–41.

    Google Scholar 

  • Chouteau, J. (1971). Respiratory gas exchange in animals during exposure to extreme ambient pressures. In: Proceedings of the Fourth Symposium on Underwater Physiology. Ed., C. J. Lambertsen. New York: Academic Press.

    Google Scholar 

  • Clark, J. M., Fisher, A. B. (1977). Oxygen toxicity and extension of tolerance in oxygen therapy. In: Hyperbaric Oxygen Therapy. Eds. J. C. Davis and T. K. Hunt. Bethesda, Maryland: Undersea Medical Society, pp. 61–77.

    Google Scholar 

  • Clark, J. M., Lambertsen, C. J. (1967). Pulmonary oxygen tolerance and the rate of development of pulmonary oxygen toxicity in man at two atmospheres inspired oxygen tension. In: Underwater Physiology. Proceedings of the Third Symposium on Underwater Physiology. Ed., C. J. Lambertsen. Baltimore, Maryland: Williams & Wilkins, pp. 439–451.

    Google Scholar 

  • Clark, J. M., Lambertsen, C. J. (1971a). Pulmonary oxygen toxicity: A review. EnPharmacol. Rev.En 23: 37–133.

    CAS  Google Scholar 

  • Clark, J. M., Lambertsen, C. J. (1971b). Rate of development of pulmonary oxygen toxicity in man during oxygen breathing at 2.0 Ata. EnJ. Appl. Physiol.En 30: 739–752.

    CAS  Google Scholar 

  • Comroe, J. H., Dripps, R. D., Dumke, P. R, Demming, M. (1945). Oxygen toxicity: The effect of inhalation of high concentrations of oxygen for twenty-four hours on normal men at sea level and at a simulated altitude of 18,000 feet. EnJ. Am. Med. Assoc.En 128: 710.

    CAS  Google Scholar 

  • Dale, W. A., Rahn, H. (1952). Rate of gas absorption during atelectasis. EnAm. J. Physiol.En 170: 606.

    PubMed  CAS  Google Scholar 

  • Daly, W., Bondurant, J. S. (1962). Effects of oxygen breathing on the heart rate, blood pressure, and cardiac index of normal men resting with reactive hyperemia and after atropine. EnJ. Clin. Invest.En 41: 126.

    Article  PubMed  CAS  Google Scholar 

  • Dejours, P., Labrousse, Y., Raynaud, J., Girard, F., Teillac, A. (1958). Stimulus oxygene de la ventilation au repos et au cours de l’exercice musculaire, a basse altitude (50m) chez l’homme. EnRev. Fr. Etud. Clin. Biol.En 3 (2): 105.

    PubMed  CAS  Google Scholar 

  • Dougherty, J. H., Jr., Frayre, R. L., Miller, C. A., Schaefer, K. E. (1978). Pulmonary function during shallow habitat air dives (Shad I, II, III). Proc. Sixth Symp. on Underwater Physiol. Eds. C. W. Shilling and M. W. Beckett. Bethesda, Maryland: FASEB., pp. 193–204.

    Google Scholar 

  • Dripps, R. D., Comroe, J. H., Jr. (1947). The effect of the inhalation of high and low oxygen concentration on respiration, pulse rate, ballis-tocardiogram and arterial oxygen saturation (oximeter) of normal individuals. EnAm. J. Physiol.En 149: 277–291.

    PubMed  CAS  Google Scholar 

  • Donald, K. W. (1947). Oxygen poisoning in man. I and II. EnBr. Med. JEn. 1:667–672, 712–717. See also Admiralty Experimental Diving Unit Report No. 16, 1946.

    Google Scholar 

  • Edmonds, C., Lowry, C., Pennefather, J. (1976). Diving and Subaquatique Medicine. Mosman, N.S.W., Australia: Diving Medical Centre Publication.

    Google Scholar 

  • Ernsting, J. (1960). Some effects of oxygen breathing. EnProc. Roy. Soc. Med.En 53: 96.

    PubMed  CAS  Google Scholar 

  • Fischer, C. L., Kimzey, S. L. (1971). Effects of oxygen on blood formation and destruction. Proceedings of the Fourth Symposium on Underwater Physiology. New York: Academic Press.

    Google Scholar 

  • Fisher, A. B., Hyde, R. W., Puy, R. J. M., Clark, J. M., Lambertsen, C. J. (1968). Effect of oxygen at 2 atmospheres on the pulmonary mechanics of normal man. EnJ. Appl. Physiol.En 24: 529–536.

    PubMed  CAS  Google Scholar 

  • Fridovich, I. (1975). Superoxide dismutases. EnAnn. Rev. Biochem.En 44: 147–159.

    Article  PubMed  CAS  Google Scholar 

  • Gable, W. D., Townsend, F. M. (1962). Lung morphology of individuals exposed to prolonged intermittent supplemental oxygen. EnAerospace MedEn. 33: 1344.

    PubMed  CAS  Google Scholar 

  • Gacad, G., Massaro, D. (1973). Hyperoxia: Influence of lung mechanics and protein synthesis. EnJ. Clin. Invest.En 52: 559–565.

    Article  PubMed  CAS  Google Scholar 

  • Gerschman, R. (1962). The biological effects of increased oxygen tension. In: Man’s Dependence on the Earthly Atmosphere, Ed., K. E. Schaefer. New York: Macmillan, p. 171.

    Google Scholar 

  • Gerschman, R, Gilbert, D. L., Nye, S. W., Dwyer, P., Fenn, W. O. (1954). Oxygen poisoning and x-irradiation: A mechanism in common. EnScienceEn 119: 623–626.

    Article  PubMed  CAS  Google Scholar 

  • Gillen, H. W. (1966). Oxygen convulsions in man. Proceedings of the Third International Conference on Hyperbaric Medicine. Eds., I. W. Brown B. G. Cox. Nat. Acad, of Sci., Washington, D. C., pp. 217–223.

    Google Scholar 

  • Green, J. E., Burgess, E. F. (1962). An investigation into the major factors contributing to post flight chest pain in fighter pilots. Flying Personnel Research Committee. Great Britain Reports No. FTRC-1182.

    Google Scholar 

  • Hart, G. B., Lee, W. S., Rasmussen, B. D., O’Reilly, R. R (1974). Complications of repetitive hyperbaric therapy. In: Proceedings of the Fifth International Hyperbaric Congress, Vol. II. Eds., W. G. Trapp, E. W. Banister, A. J. Davison, and P. A. Trapp. Burnaby, British Columbia: Simon Fraser University, pp. 867– 873.

    Google Scholar 

  • Hesser, C. M. (1962). The Role of Nitrogen in Breath-holding at Increased Pressures. In: Man’s Dependence on the Earthly Atmosphere. Ed., K. E. Schaefer. New York: Macmillan Co., p. 327.

    Google Scholar 

  • Huber, G. L., Drath, D. B. (1981). Pulmonary oxygen toxicity. This volume.

    Google Scholar 

  • Hyde, A. S., Pines, J., and Saito, I. (1963). Atele-ctasis following acceleration: A study of causality. Aerospace Med. 34: 150.

    PubMed  CAS  Google Scholar 

  • Kistler, G. S., Caldwell, P. R. B., Weibel, E. R. (1966). Quantitative electron microscopic studies of murine lung damage after exposure to 98.5% oxygen at ambient pressure: A preliminary report. Proceedings of the Third International Conference on Hyperbaric Medicine. Eds., I. W. Brown and B. G. Cox. Nat. Acad. Sci. Publ. 1404, pp. 169–178.

    Google Scholar 

  • Lambertsen, C. J., Kough, R. H., Cooper, D. V., Emmel, G. L., Loeschcke, H. H., Schmidt, C. F. (1953). Oxygen toxicity. Effects in man of oxygen inhalation at 1 and 3.5 atmospheres upon blood gas transport, cerebral circulation and cerebral metabolism. J. Appi. Physiol. 5: 471–486.

    CAS  Google Scholar 

  • Langdon, D. E., and Reynolds, G. E. (1961). Post flight respiratory symptoms associated with 100% oxygen and G-forces. EnAerospace MedEn. 32: 713.

    PubMed  CAS  Google Scholar 

  • Larkin, E. C., Adams, J. D., Williams, W. T., Duncan, D. M. (1972). Hematologic responses to hypobaric hyperoxia. EnAm. J. Physiol.En 223: 431–437.

    PubMed  CAS  Google Scholar 

  • Lennox, W. G., Behnke, A. R., Jr. (1936). Effect of increased oxygen pressure on the seizures of epilepsy. EnArch. Neurol. Psychiat.En 35: 782.

    CAS  Google Scholar 

  • Love. T. L., Schnure, J. J., Larkin, E. C., Lipman, R. L., Lecocq, F. R. (1971). Glucose intolerance in man during prolonged exposure to hypobaric-hyperoxic environment. EnDiabetesEn 20: 282–285.

    PubMed  CAS  Google Scholar 

  • Latham, F. (1951). The oxygen paradox. The experiments on the effects of oxygen in human anoxia. EnLancetEn 1: 77.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J. R, Lambertsen, C. J. (1961). Interactions of increased PQ2 and Pco2 effects in producing convulsions and death in mice. EnJ. Appi. Physiol.En 16: 1–7.

    CAS  Google Scholar 

  • McCord, J. M., Fridovich, I. (1969). Superoxide dismutase. An enzymic function for erythrocuprein EnJ. Biol. Chem.En 224: 6049–6055.

    Google Scholar 

  • McLevy, M., Jaeger, E. A., Stone, R. S., Doudna, C. T. (1962). Aeroatelectasis: A Respiratory syndrome in aviators. EnAerospace Med.En 33: 987.

    Google Scholar 

  • Meda, E. I. (1950). Effetti della respirazione di miscele ricche di O2 sull’apparato cardiovascolare dell’uomo. II. Variazione elettrocardiografiche nell’uomo durante la respirazione di O2. EnBoll. Soc. Ital. Biol. Sper.En 26: 931.

    PubMed  CAS  Google Scholar 

  • Miles, S. (1957). Oxygen syncope. Med. Res. Council, Royal Naval Personnel Research Commettee, Report No. RNT57-880, UPS 161.

    Google Scholar 

  • Miles, S., Mackay, D. E. (1976) Underwater Medicine, 4th Ed. Philadelphia: J. B. Lippincott Co.

    Google Scholar 

  • Noell, W. K. (1955). Visual cell effects of high oxygen pressures. EnFed. Proc.En 14: 107.

    Google Scholar 

  • Noell, W. K. (1962). Effects of high low oxygen tension on the visual system. In:Environmental Effects on Consciousness. Ed., K. E. Schaefer. New York: Macmillan, p3.

    Google Scholar 

  • Radomsky, M. W., Watson, W. I. (1973). Effect of lithium on acute oxygen toxicity and associated changes in brain-amino butyric acid. EnAerospace Med.En 44: 387–392.

    Google Scholar 

  • Redding, R. A., Arai, T., Douglas, W. H. J., Tsurupani, H., Oven, J. (1975). Early changes in lungs of rats exposed to 70% oxygen. EnJ. App. Physiol.En 38: 136–142.

    CAS  Google Scholar 

  • Robertson, W. G., Hargreaves, J. J., Herlicher, J. E., Welch, B. E. (1964). Physiologic response to increased oxygen partial pressure. II. Respiratory studies. EnAerospace Med.En 35: 618–622.

    PubMed  CAS  Google Scholar 

  • Ruff, S., Strughold, H. (1939). Grundriss der Luftfahrt Medizin. Leipzig: Barth.

    Google Scholar 

  • Saltzman, H. A., Hart, L., Sieker, H. O., Duffy, E. J. (1965). Retinal vascular response to hyperbaric oxygenation. EnJ. Am. Med. Assoc.En 191: 290.

    Article  CAS  Google Scholar 

  • Sanders, A. P., Gelein, R S., Currie, W. D. (1976). The effect of hyperbaric oxygenation on the metabolism of the lung. In: Underwater Physiology V. Proceedings of the Fifth Symposium on Underwater Physiology. Ed., C. J. Lambertsen. Bethesda: FASEB, pp. 483–492.

    Google Scholar 

  • Schaefer, K. E. (1956). Oxygen toxicity studies in underwater swimming. EnJ. Appl. Physiol.En 8: 524–531.

    PubMed  CAS  Google Scholar 

  • Schaefer, K. E. (1965). Circulatory adaptation to the requirements of life under more than one atmosphere of pressure. In: Handbook of Physiology, Section 2, Circulation, Vol. III. Washington, D. C.: EnAm. Physiol. SocEn. pp. 1843–1873.

    Google Scholar 

  • Schaefer, K. E. (1974). Chronic hypercapnia and oxygen toxicity at high pressure. Proceedings X XVI International Congress of Physiology, New Dehli, India.

    Google Scholar 

  • Schaefer, K. E., Avery, M. E., Bensch, K. (1964). Time course of changes in surface tension and morphology of alveolar epithelial cells in CO1 induced hyaline membrane disease. EnJ. Clin. Invest.En 43: 2080–2093.

    Article  PubMed  CAS  Google Scholar 

  • Smith, J. L. (1899). The pathological effects due to increase of oxygen tension in the air breathed. EnJ. Physiol.En 24: 29–35.

    Google Scholar 

  • Strauss, M. B., Lee, W., Cantrell, R W. (1973). Serous otitis media in divers breathing 100% oxygen. In: Presented at Annual Scientific Meeting, Aerospace Medical Association, May 7–10.

    Google Scholar 

  • Stroud, R. C. (1959). Combined ventilatory and breath-holding evaluation of sensitivity to respiratory gases. EnJ. Appl. Physiol.En 14 (3): 353–356.

    PubMed  CAS  Google Scholar 

  • Trokel, S. (1965). Effect of respiratory gases upon choroidal hemodynamics. EnArch. Ophthalmol.En 73: 838.

    PubMed  CAS  Google Scholar 

  • Valimaki, M., Juva, K., Rantanen, J. (1975). Collagen metabolism in rat lungs during chronic intermittent exposure to oxygen. EnAviat. Space Environ. Med.En 46: 684–690.

    CAS  Google Scholar 

  • Webb, P. (1962). NASA Life Sciences Data Book.

    Google Scholar 

  • Wilson, J. M., Kligfield, P., Adams, G. M., Harvey, C., Schaefer, K. E. (1977).

    Google Scholar 

  • Human ECG changes during prolonged hyperbaric exposures breathing N2–O2 mixtures. EnJ. Appl. Physiol. 42:614–633.

    Google Scholar 

  • Wood, J. D., Watson, W. H., Murray, G. W. (1969). Correlation between decreases in brain gama amino butyric acid levels and susceptibility to convulsions induced by hyperbaric oxygen. EnJ. Neurochem.En 16: 281–287.

    Article  PubMed  CAS  Google Scholar 

  • Yarbrough, O. D., Welham, W., Brinton, E. S., Behnke, A. R. (1947). Symptoms of oxygen poisoning and limits of tolerance at rest and at work. Res. Rept. No. 1, U. S. Naval Exp. Diving Unit, Washington, D. C.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag New York, Inc.

About this paper

Cite this paper

Schaefer, K.E. (1981). Oxygen in Closed Environmental Systems. In: Gilbert, D.L. (eds) Oxygen and Living Processes. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5890-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-5890-2_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5892-6

  • Online ISBN: 978-1-4612-5890-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics