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Antioxidant Defenses

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Oxygen and Living Processes

Part of the book series: Topics in Environmental Physiology and Medicine ((TEPHY))

Abstract

Gerschman first proposed that the initial event of oxygen poisoning may be the generation of toxic free radicals (28). This has led to a recent focus on free radicals generated from oxygen itself, including superoxide anion and hydroxl radical and derivatives of these radicals including H2O2 and singlet oxygen. It is now known that these partially reduced species of O2 are generated normally during cellular metabolism and, at least for some reactions, their rate of generation increases as a function of \({P_{{O_2}}}\) (26,27,46). This supports the possibility that exposure to elevated oxygen tensions results in increased generation of toxic free radicals which may then be responsible for tissue damage.

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Authors
  1. Henry J. Forman
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  2. Aron B. Fisher
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Editor information

Editors and Affiliations

  1. Marine Biological Laboratory, 02543, Woods Hole, Massachusetts, USA

    Daniel L. Gilbert Ph.D.

  2. Laboratory of Biophysics, NINCDS National Institutes of Health, Bethesda, Maryland, 20205, USA

    Daniel L. Gilbert Ph.D.

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© 1981 Springer-Verlag New York, Inc.

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Forman, H.J., Fisher, A.B. (1981). Antioxidant Defenses. In: Gilbert, D.L. (eds) Oxygen and Living Processes. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5890-2_12

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  • DOI: https://doi.org/10.1007/978-1-4612-5890-2_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5892-6

  • Online ISBN: 978-1-4612-5890-2

  • eBook Packages: Springer Book Archive

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