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Short-Term Tests for Chemical Carcinogens pp 457–473Cite as

Quantitative Measures of Induced Mutagenesis

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Part of the book series: Topics in Environmental Physiology and Medicine ((TEPHY))

Abstract

A surprisingly large number of substances have been found recently to act both as mutagens and as carcinogens (McCann et al., 1975). Unfortunately, it is not enough merely to know whether or not a chemical is a mutagen. It is essential also to determine quantitatively how mutagenic various agents are in a given assay system, and also to determine how mutable various biological systems are when treated with a given mutagen. Knowledge of the relative mutagenicity of substances is a critical element in the assessment of genetic risks associated with environmental chemicals; and knowledge of the relative mutability of organisms is important in assessing the merits of short-term test systems.

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References

  • Albertini, R.J. DeMars, R. (1973): Somatic cell mutation: detection and quantification of Xray-induced mutation in cultured, diploid human fibroblasts. Mutat. Res. 75: 199–224.

    Google Scholar 

  • Ames, B.N., Lee, F.D., Durston, W.E. (1973a): An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc. Natl. Acad. Sci. USA 70: 782–786.

    Article  PubMed  CAS  Google Scholar 

  • Ames, B.N., Durston, W.E., Yamasaki, E., Lee, F.D. (1973b): Carcinogens are mutagens: a simple test system combining liver homogenates for activation of bacteria for detection. Proc. Natl. Acad. Sci. USA 70: 2281–2285.

    Article  PubMed  CAS  Google Scholar 

  • Ames, B.N., McCann, J., Yamasaki, E. (1975): Methods for detecting carcinogens and mutagens with the Salmonella/mammalianmicrosome mutagenicity test. Mutat. Res. 37: 347–364.

    Google Scholar 

  • Drake, J.W. (1970): The Molecular Basis of Mutation. San Francisco: Holden-Day, pp. 40–50.

    Google Scholar 

  • Eckardt, F., Haynes, R.H. (1977a): Kinetics of mutation induction by ultraviolet light in excision-deficient yeast. Genetics 85: 225–241.

    PubMed  CAS  Google Scholar 

  • Eckardt, F., Haynes, R.H. (1977b): Induction of pure and sectored mutant clones in excision proficient and deficient strains of yeast. Mutat. Res. 43: 327–338.

    Article  PubMed  CAS  Google Scholar 

  • Eckardt, F., Kowalski, S., Laskowski, W. (1975): The effects of three rad genes on UV induced mutation rates in haploid and diploid Saccharomyces cells. Mol. Gen. Genet. 736: 261–272.

    Article  Google Scholar 

  • Green, M.H.L., Muriel, W.J., (1976): Mutagen testing using TRP+ reversion in Escherichia coli. Mutat. Res. 38: 3–32.

    PubMed  CAS  Google Scholar 

  • Green, M.H.L., Muriel, W.J., Bridges, B.A. (1976): Use of a simplified fluctuation test to detect low levels of mutagens. Mutat. Res. 38: 33–42.

    PubMed  CAS  Google Scholar 

  • Han, A., Elkind, M.M. (1979): Transformation of mouse C3H/10TV2 cells by single and fractionated doses of x-rays and fission spectrum neutrons. Cancer Res. 39: 123–130.

    PubMed  CAS  Google Scholar 

  • Haynes, R.H., Eckardt, F. (1979): Analysis of dose-response patterns in mutation research. Can. J. Genet. Cytol. 21: 211–302.

    Google Scholar 

  • Hill, R.F. (1965): Ultraviolet-induced lethality and reversions to prototrophy in Escherichia coli strains with normal and reduced dark repair ability. Photochem. Photobiol. 4: 563–568.

    Article  PubMed  CAS  Google Scholar 

  • Hsie, A.W., O’Neill, J.P., Couch, D.B., San Sebastian, J.R., Brimer, P.A., Machanoff, R., Fuscoe, J.C., Riddle, J.C., Li, A.P., Forbes, N.L., Hsie, M.H. (1978): Quantitative analysis of radiationand chemical-induced lethality and mutagenesis in Chinese hamster ovary cells. Radiat. Res. 76: 471–492.

    Article  PubMed  CAS  Google Scholar 

  • Ikenaga, M., Ichikawa-Ryo, H., Kondo, S. (1975): The major cause of inactivation and mutation by 4NQO in Escherichia coli: excisable 4NQO-purine adducts. J. Mol. Biol. 92: 341–356.

    Article  PubMed  CAS  Google Scholar 

  • Kondo, S. (1972): A theoretical study of spontaneous mutation rate. Mutat. Res. 14: 365–314.

    Article  PubMed  CAS  Google Scholar 

  • Kubitschek, H.E. (1970): An Introduction to Research with Continuous Cultures. Englewood Cliffs, N.J.: Prentice-Hall, Inc.

    Google Scholar 

  • Kunz, B.A., Haynes, R.H. (1978): Analysis of UV-induced mitotic recombination in yeast. In: Abstracts. 9th International Conference on Yeast Genetics and Molecular Biology, University of Rochester, Rochester, N.Y., p. 50.

    Google Scholar 

  • Lemontt, J.F. (1977): Mutagenesis of yeast by hydrazine: dependence upon post-treatment cell division. Mutat. Res. 43: 165–178.

    Article  PubMed  CAS  Google Scholar 

  • Luria, S.E., Delbrück, M. (1943): Mutations of bacteria from virus sensitivity to virus resistance. Genetics 25: 491–511.

    Google Scholar 

  • Maher, V.M., McCormick, J.J. (1976): Effect of DNA repair on the cytotoxicity and mutagenicity of UV irradiation and of chemical carcinogens in normal and xeroderma pigmentosum cells. In: J.M. Yuhas, R.W. Tennant, and J.D. Regan (eds.) Biology of Radiation Carcinogenesis. New York: Raven Press, pp. 129–145.

    Google Scholar 

  • McCann, J., Choi, E., Yamasaki, E., Ames, B.N. (1975): Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proc. Natl. Acad. Sci. USA 72: 5135–5139.

    Article  PubMed  CAS  Google Scholar 

  • Parry, J.M. (1977): The use of yeast cultures for the detection of environmental mutagens using a fluctuation test. Mutat. Res. 46: 165–176.

    PubMed  CAS  Google Scholar 

  • Patrick, M.H., Haynes, R.H., Uretz, R.B. (1964): Dark recovery phenomena in yeast. I. Comparative effects with various inactivating agents. Radiat. Res. 27: 144–163.

    Article  Google Scholar 

  • Prakash, L. (1976): Effect of genes controlling radiation sensitivity on chemically induced mutations in Saccharomyces cerevisiae. Genetics 83: 285–301.

    PubMed  CAS  Google Scholar 

  • Sherman, F., Stewart, J.W. (1978): The genetic control of yeast iso-1 and iso-2-cytochrome c after 15 years. In: M. Bacila, B.L. Horecker and A.O.M. Stoppani (eds.), Biochemistry and Genetics of Yeast: Pure and Applied Aspects. New York: Academic Press, pp. 273–316.

    Google Scholar 

  • Thacker, J. (1979): The involvement of repair processes in radiation-induced mutation of cultured mammalian cells. In: S. Okada, M. Imamura, T. Terasima, and H. Yamaguchi (eds.), Radiation Research, Proceedings of the Vlth International Congress on Radiation Research. Tokyo, Maruzen Co. Ltd., pp. 621–630.

    Google Scholar 

  • Thompson, L.H., Baker, R.M. (1973): Isolation of mutants of cultured mammalian cells. In: D.M. Prescott (ed.), Methods in Cell Biology. Vol. IV. New York: Academic Press, pp. 209–281.

    Google Scholar 

  • Unrau, P., Wheatcroft, R., Cox, B.S. (1971): The excision of pyrimidine dimers from DNA of ultraviolet irradiated yeast. Mol. Gen. Genet. 113: 359–362.

    Article  PubMed  CAS  Google Scholar 

  • von Borstel, R.C. (1978): Measuring spontaneous mutation rates in yeast. In: D.M. Prescott (ed), Methods in Cell Biology, Vol. 20. New York: Academic Press, pp. 1–24.

    Chapter  Google Scholar 

  • Witkin, E.M. (1966): Radiation induced mutations and their repair. Science 752: 1345–1352.

    Article  Google Scholar 

  • Zimmermann, F.K. (1975): Procedures used in the induction of mitotic recombination and mutation in the yeast Saccharomyces cerevisiae. Mutat. Res. 57: 71–86.

    Google Scholar 

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Authors
  1. Friederike Eckardt
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  2. Robert H. Haynes
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Editor information

Editors and Affiliations

  1. Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    H. F. Stich (Head) (Head)

  2. Carcinogen Testing Laboratory, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    R. H. C. San (Chief) (Chief)

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© 1981 Springer-Verlag New York Inc.

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Eckardt, F., Haynes, R.H. (1981). Quantitative Measures of Induced Mutagenesis. In: Stich, H.F., San, R.H.C. (eds) Short-Term Tests for Chemical Carcinogens. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5847-6_41

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  • DOI: https://doi.org/10.1007/978-1-4612-5847-6_41

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5849-0

  • Online ISBN: 978-1-4612-5847-6

  • eBook Packages: Springer Book Archive

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