Abstract
Carcinogens are present in the environment and in man himself as components of complex mixtures. Hence, the overall activity of a given carcinogen is dependent on the presence of a variety of modifying agents, some of which enhance while others suppress the action of the carcinogen. Thus, a realistic appraisal of a carcinogen’s hazard to man requires the identification of such modifying agents in his environment.
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References
Ames, B.N., McCann, J., Yamasaki, E. (1975): Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31: 347–364.
Guttenplan, J.B. (1977): Inhibition by L-ascorbate of bacterial mutagenesis induced by two N-nitroso compounds. Nature (Lond.) 268: 368–370.
Guttenplan, J.B. (1978): Mechanisms of inhibition by ascorbate of microbial mutagenesis induced by N-nitroso compounds. Cancer Res. 35: 2018–2022.
Jacobs, M.M., Matney, T.S., Griffin, C.A. (1977): Inhibitory effects of selenium on the mutagenicity of 2-acetylaminofluorene (AAF) and AAF derivatives. Cancer Lett. 2: 319–322.
Kada, T., Morita, K., Inoue, T. (1978): Anti-mutagenic action of vegetable factor(s) on the mutagenic principle of tryptophan pyrolysate. Mutat. Res. 53: 351–353.
Lesca, P., Lecointe, P., Paoletti, C., Mansuy, D. (1979): Ellipticines as potent inhibitors of microsomes-dependent chemical mutagenesis. Chem.-Biol. Interact. 25: 279–289.
Marquardt, H., Sapozink, M.D., Zedeck, M.S. (1974): Inhibition by cysteamine-HCl of oncogenesis induced by 7,12-dimethyl-benz(a)anthracene without affecting toxicity. Cancer Res. 34: 3387–3390.
Moriya, M., Kato, K., Shirasu, Y. (1978): Effects of cysteine and a liver metabolic activation system on the activities of mutagenic pesticides. Mutat. Res. 57: 259–263.
Nagao, M., Yahagi, T., Kawachi, T., Sugimura, T., Kosuge, T., Tsuji, K., Wakabayashi, K., Mizusaki, S., Matsumoto, T. (1977): Comutagenic action of norharman and harman. Proc. Japan Acad. 53: 95–98.
Oesch, F., Bentley, P., Glatt, H.R. (1976): Prevention of benzo(a)pyrene-induced mutagenicity by homogenous epoxide hydratase. Int. J. Cancer 18: 448–452.
Rannug, U., Sundvall, A., Ramel, C. (1978): The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium 1. Activation through conjugation with glutathione in vitro. Chem.-Biol. Interact. 20: 1–16.
Rosin, M.P., Stich, H.F. (1978a): Inhibitory effect of reducing agents on N-acetoxy- and N- hydroxy-2-acetylaminofluorene-induced mutagenesis. Cancer Res. 38: 1307–1310.
Rosin, M.P., Stich, H.F. (1978b): The inhibitory effect of cysteine on the mutagenic activities of several carcinogens. Mutat. Res. 54: 73–81.
Rosin, M.P., Stich, H.F. (1979): Assessment of the use of the Salmonella mutagenesis assay to determine the influence of antioxidants on carcinogen-induced mutagenesis. Int. J. Cancer 23: 122–121.
Rosin, M.P., Stich, H.F. (1980): Enhancing and inhibiting effects of propyl gallate on carcinogen-induced mutagenesis. J. Environ. Pathol. Toxicol. 4: 159–167.
Shamberger, R.J., Corlett, C.L., Beaman, K.D., Kasten, B.L. (1979): Antioxidants reduce the mutagenic effect of malonaldehyde and propiolactone. Part IX. Antioxidants and cancer. Mutat. Res. 66: 349–355.
Stich, H.F., Wei, L., Whiting, R.F. (1979): The enhancing effect of transition metals on the chromosome-damaging action of ascorbate. Cancer Res. 59: 4145–4151.
Wattenberg, L.W. (1976): Inhibition of chemical carcinogenesis by antioxidants and some additional compounds. In: P.N. Magee, S. Takayama, T. Sugimura and T. Matsushima (eds.), Fundamentals in Cancer Prevention. Tokyo, Tokyo University Press/Baltimore: University Park Press, pp. 153–166.
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Rosin, M.P. (1981). The Use of a Bacterial Assay to Identify Which Agents Modify Carcinogen-Induced Mutagenesis. In: Stich, H.F., San, R.H.C. (eds) Short-Term Tests for Chemical Carcinogens. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5847-6_40
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DOI: https://doi.org/10.1007/978-1-4612-5847-6_40
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