Abstract
Many microbial (Ames et al., 1973; Nagao and Sugimura, 1972) as well as other sub-mammalian (e.g., Neurospora: Ong and de Serres, 1972; Yeast: Koske and Stich, 1973) and mammalian (Stich and San, 1970; Stich et al., 1971, 1976) cell systems for the detection of potential carcinogens have been developed and successfully applied. They are economic and time-saving as compared to the systems consisting of entire test animals such as laboratory mice, rats, and others. However, one should keep in mind that the feasibility of these cell systems suffers from a certain ambiguity in relating the in vitro effects (e.g., mutation, numerical and structural chromosome aberrations, sister chromatid exchanges, focus-forming capacity, etc.) to the in vivo event of neoplastic transformation in the entire animal. In vitro cell test systems, therefore, cannot satisfactorily replace in vivo test systems.
This paper contains parts of the habilitation thesis of M. Schwab and parts of the dissertation of E. Scholl.
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Anders, F., Schwab, M., Scholl, E. (1981). Strategy for Breeding Test Animals of High Susceptibility to Carcinogens. In: Stich, H.F., San, R.H.C. (eds) Short-Term Tests for Chemical Carcinogens. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5847-6_35
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DOI: https://doi.org/10.1007/978-1-4612-5847-6_35
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