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Recent Achievements with Drosophila as an Assay System for Carcinogens

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Short-Term Tests for Chemical Carcinogens

Part of the book series: Topics in Environmental Physiology and Medicine ((TEPHY))

Abstract

About 1911, T.H. Morgan began genetic studies with Drosophila. Since then the work with Drosophila has been greatly extended, because this test organism combines a eukaryotic organization with a unique range of test systems. Drosophila is the only in vivo test organism which permits the simultaneous and efficient testing of the various types of genetic lesions from the molecular to the chromosome level. Stocks are available or can be constructed to test in gonadal or somatic tissues for gene mutations, deletions, and for almost all possible types of chromosome rearrangements. Special test protocols have been devised to recover aneuploidy resulting from nondisjunctional events.

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Authors
  1. E. Vogel
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Editors and Affiliations

  1. Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    H. F. Stich (Head) (Head)

  2. Carcinogen Testing Laboratory, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    R. H. C. San (Chief) (Chief)

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Vogel, E. (1981). Recent Achievements with Drosophila as an Assay System for Carcinogens. In: Stich, H.F., San, R.H.C. (eds) Short-Term Tests for Chemical Carcinogens. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5847-6_34

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  • DOI: https://doi.org/10.1007/978-1-4612-5847-6_34

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5849-0

  • Online ISBN: 978-1-4612-5847-6

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