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Malignant Tumors

  • William P. LongmireJr.
  • Ronald K. Tompkins
Chapter
Part of the Comprehensive Manuals of Surgical Specialties book series (CMSS)

Abstract

Primary hepatic cancer is rare in North and South America, Europe, Russia, and Australia. In contrast, the disease has a very high incidence in Southeast Asia, China, and Africa. In some tribes among the black population south of the Sahara, cancer of the liver is the most common abdominal malignancy in males. The incidence of liver cancer among blacks in the United States is similar to that in the white population, which strongly suggests an external causative factor such as the aflatoxins B and G of the mold Aspergillus flavus, known to be a contaminant of foodstuffs in the diet of some African people with a high incidence of hepatoma. In some parts of the world the association of hepatoma with parasitic infestations, such as schistosomiasis and clonorchiasis, has been noted, but the relationship remains obscure. Cycasin from cycad nuts may produce hepatic as well as renal and other neoplasms. In a previous report, 74 of 144 patients with primary carcinoma of the liver seen at the UCLA and Wadsworth Veterans Administration Hospitals had proved cirrhosis of the liver [32]; 54 of these patients had a previous history of alcoholism and 8 had hepatitis.

Keywords

Hepatic Artery Hepatic Resection Hepatic Metastasis Intrahepatic Bile Duct Primary Liver Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adson MA, Sheedy PF: Resection of primary hepatic malignant lesions. Arch Surg 108: 599–604, 1974PubMedGoogle Scholar
  2. 2.
    Adson MA, Van Heerden JA: Major hepatic resection for metastatic colorectal cancer. Ann Surg 191: 576–580, 1980PubMedCrossRefGoogle Scholar
  3. 3.
    Alrenga DP: Primary fibrosarcoma of the liver. Cancer 36: 446–449, 1975PubMedCrossRefGoogle Scholar
  4. 4.
    Altman D: Hepatoma: Medical staff conference, University of California, San Francisco. West J Med 132: 514–520, 1980Google Scholar
  5. 5.
    Ariel IM: The treatment of primary and metastatic cancer of the liver. Surgery 39: 70–91, 1956PubMedGoogle Scholar
  6. 6.
    Attiyeh FF, Wanebo HJ, Stearns MW: Hepatic resection for metastasis from colorectal cancer. Dis Colon Rectum 21: 160–162, 1978PubMedCrossRefGoogle Scholar
  7. 7.
    Balasegaram M: Hepatic resection for malignant tumors. Surg Rounds Sept 1979, pp 14–26Google Scholar
  8. 8.
    Bengmark S, Börjesson B, Hafström L: The natural history of primary carcinoma of the liver. Scan J Gastroenterol 6: 351–355, 1971CrossRefGoogle Scholar
  9. 9.
    Bengmark S, Hafström L: The natural history of primary and secondary malignant tumors of the liver. I. The Prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy. Cancer 23: 198–202, 1969PubMedCrossRefGoogle Scholar
  10. 10.
    Berman C: Malignant disease in the Bantu of Johannesburg and the Witwatersrand gold mines. S Afr J Med Sci 1: 12–30, 1935Google Scholar
  11. 11.
    Berman C: Primary Carcinoma of the Liver: A Study in Incidence, Clinical Manifestations, Pathology and Aetiology. London, Lewis, 1951Google Scholar
  12. 12.
    Cochrane AMG, Murray-Lyon IM, Brinkley DM, Williams R: Quadruple che-motherapy versus radiotherapy in treatment of primary hepatocellular carcinoma. Cancer 40: 609–618, 1977PubMedCrossRefGoogle Scholar
  13. 13.
    Cohen L, Shapiro MP, Keen P, Cohen A, deMoor NG: Experimental radiotherapy of abdominal cancer. IV: Radiosensitivity of liver tumours. Br J Radiol 27: 402–406, 1954PubMedCrossRefGoogle Scholar
  14. 14.
    Doyon D, Mouzon, A, Jourde A-M, Regensberg C, Frileux C: L’embolisation artérielle hépatique dans les tumeurs malignes du foie. Ann Radiol (Paris) 17: 592–603, 1974Google Scholar
  15. 15.
    Edmondson HA: Tumors of the Liver and Intrahepatic Bile Ducts. Atlas of Tumor Pathology, Section 7, Fascicle 25. Washington DC, Armed Forces Institute of Pathology, 1958, pp 32–112Google Scholar
  16. 16.
    El-Domeiri AA, Huvos AG, Goldsmith HS, Foote FW Jr: Primary malignant tumors of the liver. Cancer 27: 7–11, 1971PubMedCrossRefGoogle Scholar
  17. 17.
    Falkson G: The treatment of liver cell cancer. In HM Cameron, DA Linsell, GP Warwick (eds), Liver Cell Cancer. New York, Elsevier, 1976, pp 81–92Google Scholar
  18. 18.
    Fenster LF, Klatskin G: Manifestation of metastatic tumors of the liver: A study of eighty-one patients subjected to needle biopsy. Am J Med 31: 238–248, 1961PubMedCrossRefGoogle Scholar
  19. 19.
    Fong JA, Ruebner BH: Primary leiomyosarcoma of the liver. Hum Pathol 5: 115–119, 1974PubMedCrossRefGoogle Scholar
  20. 20.
    Fortner JG, Kim DK, MacLean BJ, Barrett MK, Iwatsuki S, Turnbull AD, Howland WS, Beattie EJ Jr: Major hepatic resection for neoplasia: Personal experience in 108 patients. Ann Surg 188: 363–370, 1978PubMedCrossRefGoogle Scholar
  21. 21.
    Foster JH, Berman MM: Solid Liver Tumors. Major Problems in Clinical Surgery, Vol. 22. Philadelphia, Saunders, 1977Google Scholar
  22. 22.
    Hanks JB, Meyers WC, Filston HC, Killenberg PG, Jones RS: Surgical resection for benign and malignant disease. Ann Surg 191: 584–590, 1980PubMedCrossRefGoogle Scholar
  23. 23.
    Haskell CM (ed): Cancer Treatment. Philadelphia, Saunders, 1980, pp 167–168Google Scholar
  24. 24.
    Jaffe BM, Donegan WL, Watson F, Spratt JS Jr: Factors influencing survival in patients with untreated hepatic metastases. Surg Gynecol Obstet 127: 1–11, 1968PubMedGoogle Scholar
  25. 25.
    Kan YW, McFadzean AJS, Todd D, Tso SC: Further observations on polycythemia in hepatocellular carcinoma. Blood 18: 592–598, 1961Google Scholar
  26. 26.
    Kasai M, Watanabe I: Histologic classification of liver-cell carcinoma in infancy and childhood and its clinical evaluation. Cancer 25: 551–563, 1970PubMedCrossRefGoogle Scholar
  27. 27.
    Kew MC: Hepatoma and the HBV. In GN Vyas, SN Cohen, R Schmid (eds), Viral Hepatitis. Philadelphia, Franklin Institute Press, 1978, pp 439–450Google Scholar
  28. 28.
    Lee Y-TN: Liver function tests after ligation of hepatic artery. J Surg Oncol 10: 305–320, 1978PubMedCrossRefGoogle Scholar
  29. 29.
    Lin TY: Primary cancer of the liver. Scand J Gastroenterol 5 (Suppl 6): 223–241, 1970Google Scholar
  30. 30.
    Lin TY: Results in 107 hepatic lobectomies with a preliminary report on the use of a clamp to reduce blood loss. Ann Surg 177: 413–421, 1973PubMedCrossRefGoogle Scholar
  31. 31.
    Longmire WP Jr: Hepatic resection. In RM Zollinger (ed), Advances in Surgery, Vol 8. Chicago, Year Book, 1974, pp 29–61Google Scholar
  32. 32.
    Longmire WP Jr, Passaro EP, Joseph WL: The surgical treatment of hepatic lesions. Br J Surg 53: 852–859, 1966PubMedCrossRefGoogle Scholar
  33. 33.
    Longmire WP Jr, Trout HA III, Greenfield J, Tompkins RK: Elective hepatic surgery. Ann Surg 179: 712–721, 1974PubMedCrossRefGoogle Scholar
  34. 34.
    Markowitz J: The hepatic artery. Surg Gynecol Obstet 95: 644–646, 1952PubMedGoogle Scholar
  35. 35.
    McDermott WV Jr, Paris Al, Clouse ME, Meissner WA: Dearterialization of the liver for metastatic cancer: Clinical, angiographic and pathologic observations. Ann Surg 187: 38–46, 1978PubMedCrossRefGoogle Scholar
  36. 36.
    Moertel CG: Chemotherapy of gastrointestinal cancer. N Engl J Med 299: 1049–1052, 1978PubMedCrossRefGoogle Scholar
  37. 37.
    Olweny CLM, Toya T, Katongole-Mbidde E, Mugerwa J, Kyalwazi SK, Cohen H: Treatment of hepatocellular carcinoma with Adriamycin: Preliminary communication. Cancer 36: 1250–1257, 1975PubMedCrossRefGoogle Scholar
  38. 38.
    Ong GB, Chan PKW: Primary carcinoma of the liver. Surg Gynecol Obstet 143: 31–38, 1976PubMedGoogle Scholar
  39. 39.
    Ong GB, Leong CH: Surgical treatment of primary liver cancer. J R Coll Surg Edinb 14: 42–55, 1969PubMedGoogle Scholar
  40. 40.
    Pack GT, Brasfield RD: Metastatic cancer of the liver: The clinical problem and its management. Am J Surg 90: 704 — 716, 1955PubMedCrossRefGoogle Scholar
  41. 41.
    Pestana C, Reitemeier RJ, Moertel CG, Judd ES, Dockerty MB: The natural history of carcinoma of the colon and rectum. Am J Surg 108: 826–829, 1964PubMedCrossRefGoogle Scholar
  42. 42.
    Phillips R, Murikami K: Primary neoplasms of the liver: Results of radiation therapy. Cancer 13: 714–720, 1960PubMedCrossRefGoogle Scholar
  43. 43.
    Plengvanit U, Viranuvatti V, Chearanai O: Treatment of primary liver carcinoma. Med Chir Dig 3: 301–306, 1974PubMedGoogle Scholar
  44. 44.
    Ramming KP, Haskell CM, Tesler AS: Gastrointestinal tract neoplasms. In CM Haskell (ed), Cancer Treatment. Philadelphia, Saunders, 1980, pp 231–357Google Scholar
  45. 45.
    Silverberg E: Cancer statistics, 1979. Cancer 29: 6–21, 1979Google Scholar
  46. 46.
    Smith R: Tumours of the liver. Ann R Coll Surg Engl 61: 87–99, 1979PubMedGoogle Scholar
  47. 47.
    Sparks FC, Mosher MB, Hallauer WC, Silverstein MJ, Rangel D, Passaro E Jr, Morton DL: Hepatic artery ligation and postoperative chemotherapy for he¬patic metastases: Clinical and pathophysiological results. Cancer 35: 1074–1082, 1975PubMedCrossRefGoogle Scholar
  48. 48.
    Starzl T: Discussion of Fortner JG et al (ref. 20 above). Ann Surg 188: 370–371, 1978Google Scholar
  49. 49.
    Stehlin JS Jr, Hafström L, Greef PJ: Experience with infusion and resection in cancer of the liver. Surg Gynecol Obstet 138: 855–863, 1974PubMedGoogle Scholar
  50. 50.
    Storm FK, Harrison WH, Elliott RS, Morton DL: Normal tissue and solid tumor effects of hyperthermia in animal models and clinical trials. Cancer Res 39: 2245–2251, 1979PubMedGoogle Scholar
  51. 51.
    Weichselbaum RR, Cassady JR, Jaffe N, Filler R: The evolution of combination therapy of genitourinary rhabdomyosarcoma in children: A preliminary report. Int J Radiat Oncol Biol Phys 2: 267–272, 1977PubMedCrossRefGoogle Scholar
  52. 52.
    Willis RA: The Spread of Tumours in the Human Body, 2nd ed. London, Butter- worth, 1952Google Scholar
  53. 53.
    Wu M-C: Resection of primary hepatic carcinoma during a period of eighteen years. Reprint from the First Affiliated Hospital of the Second Military Medical College, Shanghai, China, 1978Google Scholar
  54. 54.
    Zahlten RN: Liver cancer treatment: Present status. Medical Grand Rounds, University of Texas, Southwestern Medical School at Dallas, March 8, 1979Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • William P. LongmireJr.
    • 1
  • Ronald K. Tompkins
    • 2
  1. 1.Department of SurgeryUCLA School of MedicineLos AngelesUSA
  2. 2.UCLA School of MedicineLos AngelesUSA

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