Abstract
A wealth of evidence indicates that copper(II) complexes may prevent or retard an inflammatory response (1). Various mechanisms have been proposed. One that is currently favoured is that these complexes may mimic the cupriprotein superoxide dismutase (SOD) in destroying superoxide ions (2). An apparently ‘simple’ test of this hypothesis is (a) to construct systems involving the generation and detection of the superoxide ion and its secondary oxidation products (peroxide and hydroxyl radical), and then (b) to compare the efficacy of these complexes as inhibitors with an SOD preparation of known activity.
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Betts, W.H., Cleland, L.G., Whitehouse, M.W. (1982). In Vitro Studies of Anti-Inflammatory Copper Complexes: Some Difficulties in their Chemical Interpretation. In: Sorenson, J.R.J. (eds) Inflammatory Diseases and Copper. Experimental Biology and Medicine, vol 2. Humana Press. https://doi.org/10.1007/978-1-4612-5829-2_49
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DOI: https://doi.org/10.1007/978-1-4612-5829-2_49
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