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Inflammatory Diseases and Copper pp 529–542Cite as

Molecular Mechanism of Zinc Action, and a Note on the Treatment of SLE in the Mouse with Zinc

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Part of the book series: Experimental Biology and Medicine ((EBAM,volume 2))

Abstract

We believe a major clue as to the molecular mechanism of zinc action at pharmacological dosage levels can be derived from the existence of zinc-calcium antagonism (Brewer, 1980). Since we have considerable information about the molecular mechanism of calcium action, zinc antagonism to those actions suggests that we explore the possibility of a related molecular mechanism of action for zinc.

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References

  • M.G. Ardlie, E.E. Nishizawa, M. Guciione, Fed. Proc. 30, 423 (1970).

    Google Scholar 

  • T. Asakura, S.T. Ohnishi, K. Adachi, M. Ozguc, K. Hashimoto, M. Singer, M. Russell, E. Schwartz, Proc. Natl. Acad. Sci. 77, 2955 (1980).

    Article  CAS  Google Scholar 

  • R. Baker, D. Powars, L.J. Haywood, in “Erythrocyte Structure and Function,” G.J. Brewer, Ed., Alan R. Liss, New York, 1974, p. 437 ff.

    Google Scholar 

  • L.J. Benjamin, G. Kokkini, C.M. Peterson, Blood 55, 265 (1980).

    PubMed  CAS  Google Scholar 

  • U.L. Bereza, G.J. Brewer, Clin. Res. 28, A759 (1980).

    Google Scholar 

  • G.H. Bond, D.L. Clough, Biochim. Biophys. Acta 323, 592 (1973).

    Article  CAS  Google Scholar 

  • D. Bottechia, G.P. Fantin, Thromb. Diath. Haemorrh. 30, 567 (1973).

    Google Scholar 

  • G.J. Brewer, Amer. J. Hemat. 8, 231 (1980).

    Article  CAS  Google Scholar 

  • G.J. Brewer, J.C. Aster, Prog. Am. Soc. Hum. Genet. 39A (1979).

    Google Scholar 

  • G.J. Brewer, F.J. Oelshlegel, Jr., Biochem. Biophys. Res. Commun. 58, 854 (1974).

    Article  PubMed  CAS  Google Scholar 

  • G.J. Brewer, J.C. Aster, C.A. Knutsen, W.C. Kruckeberg, Am. J. Hemat. 7, 53 (1979)

    Article  PubMed  CAS  Google Scholar 

  • G.J. Brewer, U. Bereza, I. Mizukami, J.C. Aster, L.F. Brewer, in “The Red Cell: Fifth Ann Arbor Conference,” G.J. Brewer, Ed., Alan R. Liss, New York, 1981a, p. 187 ff.

    Google Scholar 

  • G.J. Brewer, L.F. Brewer, A.S. Prasad, J. Lab. Clin. Med. 90, 549 (1977)

    CAS  Google Scholar 

  • G.J. Brewer, F. Ellis, L. Bjork, Pharmacology (In Press, 1981b).

    Google Scholar 

  • C. O. Brostrom, Y.C. Huang, B.M. Breckenridge, D.J. Wolff, Proc. Natl. Acad. Sci. 72, 64 (1970).

    Article  Google Scholar 

  • W.Y. Cheung, Biophys. Res. Commun. 38, 533 (1970).

    CAS  Google Scholar 

  • W.Y. Cheung, T.J. Lynch, R.W. Wallace, in “Advances in Cyclic Nucleotide Research,” W.J. George, L.F. Ignarro, Eds., Raven Press, New York, 1978, p. 233 ff.

    Google Scholar 

  • P. Cohen, A. Burchell, J.G. Foulkes, P.T.W. Cohen, T.C. Vanamen, A.C. Nairn, FEBS Lett. 92, 287 (1978).

    Article  PubMed  CAS  Google Scholar 

  • M. Chvapil, Med. Clin. North. Am. 60, 799 (1976).

    PubMed  CAS  Google Scholar 

  • M, Chvapil, L. Stankova, C. Zukoski, IV, C. Zukoski III, J. Lab. Clin. Med. 89, 135 (1977).

    Google Scholar 

  • M. Chvapil, P.L. Weldy, L. Stankova, D.S. Clark, C.F. Zukoski, Life Sci. 16, 561 (1975).

    Article  PubMed  CAS  Google Scholar 

  • S. Dash, G.J. Brewer, F.J. Oelshlegel, Jr., Nature 250, 251 (1974).

    Article  CAS  Google Scholar 

  • R. Drabowska, O.D. Aromatoril, J.M.F. Sherry, D.J. Hartshorne, Biochem. Biophys. Res. Commun. 78, 1263, 1977.

    Article  Google Scholar 

  • J.W. Eaton, E. Berger, J.G. White~H.S. Jacob, in “Zinc Metabolism: Current Aspects in Health and Disease,” G.J. Brewer, A.S. Prasad, Eds., Alan R. Liss, New York, 1977, p. 275 ff.

    Google Scholar 

  • J.W. Eaton, T.D. Skelton, J.S. Swofford, C.F. Kolpin, H.S. Jacob, Nature 246, 105 (1973).

    Article  PubMed  CAS  Google Scholar 

  • N. Grosman, B., Diamant, Agents Actions 4, 198 (1974).

    Article  CAS  Google Scholar 

  • G.L.A. Harris, D.H. Cove, N. Crawford, Biochem. Med. 11, 10 (1974).

    Article  PubMed  CAS  Google Scholar 

  • R.P. Hebbel, J.W. Eaton, M.H. Steinberg, and J.G. White, in “The Red Cell: Fifth Ann Arbor Conference,” G.J. Brewer, Ed., Alan R. Liss, New York, 1981, p. 145 ff.

    Google Scholar 

  • R.P. Hebbel, 0. Yamada, C.F. Moldow, H.S. Jacob, J.G. White, J.W. Eaton, J. Clin. Invest. 65, 154 (1980).

    Article  PubMed  CAS  Google Scholar 

  • B. Högberg, B. Uvnäs, Acta Physiol. Scand. 48, 133 (1960).

    Article  PubMed  Google Scholar 

  • R. Hoover, R. Rubin, G. Wise, R. Warren, Blood 54, 872 (1979).

    PubMed  CAS  Google Scholar 

  • S. Kakiuchi, R. Yamazaki, H. Nakajima, Proc. Jpn. Acad. 46, 587 (1970).

    CAS  Google Scholar 

  • W. Kazimierczak, C. Maslinski, Agent Actions 4, 1 (1974a).

    Article  CAS  Google Scholar 

  • W. Kazimierczak, C. Maslinski, Agent Actions 4, 320 (1974b).

    Article  CAS  Google Scholar 

  • P. Kretzschmar, G.J. Brewer, S.E. Walker, Submitted for publication, 1981.

    Google Scholar 

  • W.C. Kruckeberg, C. Knutsen, G.J. Brewer, in “Zinc Metabolism: Current Aspects in Health and Disease,” G.J. Brewer, A.S. Prasad, Eds., Alan R. Liss, New York, 1977b, p. 259, ff.

    Google Scholar 

  • W.C. Kruckeberg, F.J. Oelshlegel, Jr., S.H. Shore, P. E. Smouse, G.J. Brewer, Res. Exp. Med. 170, 149 (1977b).

    Article  CAS  Google Scholar 

  • J.M. Marcum, J.R. Dedman, B.R. Brinkely, A.W. Means, Proc. Natl. Acad. Sci. 75, 3771 (1978).

    Article  CAS  Google Scholar 

  • F.J. Oelshlegel, G.J. Brewer, in “Zinc Metabolism: Current Aspects in Health and Disease”, G.J. Brewer, A.S. Prasad, Eds., Alan K. Liss, New York, 1977, p. 299 ff.

    Google Scholar 

  • J.S. Palek, W.A. Curby, F.J. Lionetti, Am. J. Physiol. 220, 19 (1971).

    PubMed  CAS  Google Scholar 

  • S.A. Patkar, B. Diamant, Agents Actions 4, 200 (1974).

    Article  PubMed  CAS  Google Scholar 

  • A. Pletscher, M. DaPrada, J.P. Tranzer, Experientia (Basel) 24, 1202 (1968).

    Article  CAS  Google Scholar 

  • P. Seeman, Pharmacol. Rev. 24, 583 (1972).

    PubMed  CAS  Google Scholar 

  • T.P. Stossel, J. Cell Biol. 58, 346 (1973).

    Article  PubMed  CAS  Google Scholar 

  • K. Vagi, M. Yazawa, S. Kakuichi, M. Oshimo, K. Uenishi, J. Biol. Chem. 253, 1338 (1978).

    Google Scholar 

  • R.I. Weed, B. Chailley, in “Erythrocytes, Thrombocytes, Leukocytes,” E. Gerlach, K. Moser, E. Deutsch, W. Wilmans, Eds., Georg Thieme Publishers, Stuttgart, 1973, p. 45 ff.

    Google Scholar 

  • R.I. Weed, PL. Lacelle, E.W. Merrill, J. Clin. Invest. 48, 795 (1969).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

    George J. Brewer, Ulana Bereza, Peter Kretzchmar, Lucia F. Brewer & Jon C. Aster

Authors
  1. George J. Brewer
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  2. Ulana Bereza
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  3. Peter Kretzchmar
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  4. Lucia F. Brewer
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  5. Jon C. Aster
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Editor information

Editors and Affiliations

  1. Department of Biopharmaceutical Sciences, College of Pharmacy and Department of Pharmacology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA

    John R. J. Sorenson

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© 1982 The Humana Press Inc.

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Brewer, G.J., Bereza, U., Kretzchmar, P., Brewer, L.F., Aster, J.C. (1982). Molecular Mechanism of Zinc Action, and a Note on the Treatment of SLE in the Mouse with Zinc. In: Sorenson, J.R.J. (eds) Inflammatory Diseases and Copper. Experimental Biology and Medicine, vol 2. Humana Press. https://doi.org/10.1007/978-1-4612-5829-2_47

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  • DOI: https://doi.org/10.1007/978-1-4612-5829-2_47

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-5831-5

  • Online ISBN: 978-1-4612-5829-2

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