Treatment of Rheumatoid Arthritis With Zinc Sulfate
Before I review the present status of oral zinc supplements in rheumatoid arthritis, I believe it is appropriate to briefly describe this disease and the accepted approach used in evaluating new therapeutic agents. Rheumatoid arthritis is a chronic inflammatory disease primarily affecting the joints but often also attacking additional organ systems. The illness is best recognized by a symmetrical pattern of inflamed peripheral joints which ultimately may become deformed and destroyed. Because the disease characteristically fluctuates, it is not possible to distinguish between spontaneous remissions and those induced by therapy in individual patients. Because the etiology is unknown, all therapeutic agents are empirical and suppressive rather than curative in nature.
KeywordsPlacebo Zinc Fatigue Arthritis Corticosteroid
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- 2.S.N. Desai, Personal communication,Google Scholar
- 4.Ch. Job, C.J. Menkes, A. De Gery, H. Brouilhet, and F. Delbarre, in “Histidine II; Laboratory and Clinical Aspects - Therapeutic Use of Histidine and Zinc, G Partsch, and S. Batsford, Eds,, George Thieme Verlag, Stuttgart, 1980, p. 71 ff.Google Scholar
- 6.R.C. Mattingly and A.G Mowat (Presentation at 15th International Congress of Rheumatology, Paris, June, 1981 ).Google Scholar
- 9.J.R.J.Sorenson, Inorg. Perspectives Biol. Med., 2, 1 (1978).Google Scholar
- 10.D.M. Grennan, J.M.L. Knudson, M.J. MacKinnon, D.B. Myers, and D.G. Palmer, NZ Med. J., 21, 47 (1980).Google Scholar
- 12.P.A. Simkin, Agents Actions, 8, 587 (1981).Google Scholar