The Antiulcer Activities of Copper Complexes
Copper complexes of several naturally occurring L-amino acids and D-Pencillamine were synthesized. These compounds were evaluated for their antiulcer, activities in the Shay model of rat ulcer. All complexes were found to be effective in reducing the severity and/or number of ulcers as well as In reducing Shay rat mortality. Antiulcer activity of copper-amino acid complexes. was Found to decrease with increasing lipophilicity of the ligand. All copper-complexes containing L-histidine as a ligand were found to be poorly active. Formation of copper-histamine complex in vivo is suggested as a possible mechanism of action of these compounds.
KeywordsHistamine Histidine Perforation Phenylalanine Asparaginate
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