The Antiulcer Activities of Copper Complexes

  • Vimal Kishore
  • T. M. Rolniak
  • K. Ramakrishna
  • John R. J. Sorenson
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 2)

Abstract

Copper complexes of several naturally occurring L-amino acids and D-Pencillamine were synthesized. These compounds were evaluated for their antiulcer, activities in the Shay model of rat ulcer. All complexes were found to be effective in reducing the severity and/or number of ulcers as well as In reducing Shay rat mortality. Antiulcer activity of copper-amino acid complexes. was Found to decrease with increasing lipophilicity of the ligand. All copper-complexes containing L-histidine as a ligand were found to be poorly active. Formation of copper-histamine complex in vivo is suggested as a possible mechanism of action of these compounds.

Keywords

Histamine Histidine Perforation Phenylalanine Asparaginate 

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Copyright information

© The Humana Press Inc. 1982

Authors and Affiliations

  • Vimal Kishore
    • 1
  • T. M. Rolniak
    • 1
  • K. Ramakrishna
    • 2
  • John R. J. Sorenson
    • 1
  1. 1.Department of Biopharmaceutical Sciences, College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Department of ChemistryLane CollegeJacksonUSA

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