Abstract
Copper complexes of several naturally occurring L-amino acids and D-Pencillamine were synthesized. These compounds were evaluated for their antiulcer, activities in the Shay model of rat ulcer. All complexes were found to be effective in reducing the severity and/or number of ulcers as well as In reducing Shay rat mortality. Antiulcer activity of copper-amino acid complexes. was Found to decrease with increasing lipophilicity of the ligand. All copper-complexes containing L-histidine as a ligand were found to be poorly active. Formation of copper-histamine complex in vivo is suggested as a possible mechanism of action of these compounds.
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© 1982 The Humana Press Inc.
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Kishore, V., Rolniak, T.M., Ramakrishna, K., Sorenson, J.R.J. (1982). The Antiulcer Activities of Copper Complexes. In: Sorenson, J.R.J. (eds) Inflammatory Diseases and Copper. Experimental Biology and Medicine, vol 2. Humana Press. https://doi.org/10.1007/978-1-4612-5829-2_34
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DOI: https://doi.org/10.1007/978-1-4612-5829-2_34
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