The Metabolism of Gold: Possible Mechanisms for Perturbations of Copper and Zinc Homeostasis
The use of gold complexes - chrysotherapy - for treating rheumatoid arthritis is well established and can actually alter the course of the disease, unlike most anti-inflammatory drugs which do not stop the underlying tissue damage (1). Although many theories of action have been proposed (1), none can be considered to be well established and space does not permit a detailed evaluation of them. However, one possibility, which is not exclusive of other postulated mechanisms, is that gold may affect copper and zinc homeostasis. Indeed these essential metals - as well as penicillamine which chelates both of them - have been used to treat arthritis.
KeywordsRheumatoid Arthritis Lysyl Oxidase Gold Compound Zinc Homeostasis Birth Control Pill
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- 1.C. F. Shaw III, Inorg. Persp. Med. Biol., 2, 287–355 (1979).Google Scholar
- 3.D. T. Hill, B. M. Sutton, P. J. Sadler, G. H. M. Kalis, and J. M. Trooster, 179th Meeting of the ACS, Houston, IX, 1980, Abstract MED 1–16.Google Scholar
- 4.M. Mazid, M. Razi, P. J. Sadler, G. N. Greaves, S. Gurman, M. Koch and J. Phillips, Chem. Commun., 1261 (1980).Google Scholar
- 5.A. A. Isab and P. J. Sadler, Chem. Commun., 1051–2 (1976).Google Scholar
- 7.C. F. Shaw, J. Eldrige and M. P. Cancro, unpublished results.Google Scholar
- 8.D. T. Hill and B. M. Sutton, Crystal Structure Commun., 9, 679 (1980).Google Scholar
- 9.J. Laib and C. F. Shaw, unpublished studies.Google Scholar
- 11.C. J. Danpure, Biochem. Soc. Trans., 4, 536–544 (1977).Google Scholar
- 13.D. A. Campion, R. Olsen, A. Bohan, and R. Bluestone, J. Rheumatol. Suppl., 1, 112 (1974).Google Scholar
- 19.C. F. Shaw, H. O. Thompson, P. Witkiewicz and R. W. Satre, Toxicol. Appl. Pharm., in press.Google Scholar
- 21.C.F. Shaw III, “Trace Elements in the Pathogenesis and Treatment of Inflammatory Conditions,” K. Rainsford, K. Brune and M.W. Whitehouse, Eds., Birkhäuser-Verlag, Basel, 1980, pp. 509–528.Google Scholar