Abstract
The hypothesis presented here is an attempt to highlight the importance of trace metal variations in the initiation and development of arthritic conditions. This hypothesis can be stated formally thus:
“Dietary and environmentally-induced perturbations in the levels of certain trace metals, particularly as they influence the copper ion status, are contributory factors in the etiology of rheumatoid arthritis, osteoarthritis and related arthropathies, together with the primary infectious agent(s) e.g. arthritogenic viruses or bacteria, and/or injurious insult (as in osteoarthritis).”
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Rainsford, K.D. (1982). Environmental Metal Ion Perturbations, Especially as They Affect Copper Status, are a Factor in the Etiology of Arthritic Conditions: An Hypothesis. In: Sorenson, J.R.J. (eds) Inflammatory Diseases and Copper. Experimental Biology and Medicine, vol 2. Humana Press. https://doi.org/10.1007/978-1-4612-5829-2_13
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