The T Cell Antigen Receptor

Structural and Functional Considerations
  • Albert A. Luderer
  • Michael A. Harvey
Part of the Contemporary Immunology book series (CONTIM)


Initiation of the immune response following antigenic challenge begins with the specific interaction of epitopes on the antigen- and plasma membrane-associated receptors found on the cell surface of lymphocytes. Certainly the interaction of antigen with both regulatory and effector thymus-derived lymphocytes (T cells) is a critical event in this process. According to clonal selection theories (Burnett, 1969), antigen initially interacts with a relatively small number of T cells that exhibit antigen receptors of the appropriate specificity.


Cell Receptor Radioreceptor Assay Cell Antigen Receptor Clonal Selection Theory Cell Receptor Repertoire 
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  1. Adorini, L., A. Miller, and E. E. Sercarz (1979a),J. Immunol.122, 871.PubMedGoogle Scholar
  2. Adorini, L., M. A. Harvey, A. Miller, and E., Sercarz (1979b),J. Exp. Med. 150, 293.PubMedGoogle Scholar
  3. Bach, J. F. (1973),Contemp. Top. Immunol. 189.Google Scholar
  4. Baston, A., J. A. F. P. Miller, and P. Johnson (1975),Transplant. Rev. 26, 130.Google Scholar
  5. Baxevanis, C. N., D. Wernert, Z. A. Nagy, P. H. Maurer, and J. Klein (1980),Immunogenetics 11, 617.PubMedGoogle Scholar
  6. Benacerraf, B. (1978),J. Immunol.120, 1980.Google Scholar
  7. Benjamin, D. C. (1975),J. Exp. Med. 141, 635.PubMedGoogle Scholar
  8. Ben-Sasson, S. Z., E. M. Shevach, I. Green, and W. E. Paul (1974),J. Exp. Med. 140, 383.PubMedGoogle Scholar
  9. Bernoco, D., S. Cullen, G. Scudeller, G. Trinchieri, and R. Ceppellini (1973), in Histocompatibility Testing (Dausset, J., and J. Colombani, eds), Munksgard, Copenhagen, p. 527.Google Scholar
  10. Bevan, M. (1975),Nature 256, 419.PubMedGoogle Scholar
  11. Binz, H., and H. Wigzell (1977),Contemp. Topics Immunobiol. 7, 113.Google Scholar
  12. Blank, K. J., and F. Lilly (1977),Nature 269, 808.PubMedGoogle Scholar
  13. Blank, K. K., H. A. Freedman, and F. Lilly (1976),Nature 260, 250.PubMedGoogle Scholar
  14. Burnett, Sir F. M. (1969),Self and Cellular Immunology (Book 1 ), Cambridge University Press, New York.Google Scholar
  15. Cantor, H., and E. Boyse (1977),Contemp. Topics Immunobiol. 7, 47.Google Scholar
  16. Chesnut, R. W., R. O. Endres, and H. M. Grey (1980),Clin. Immunol. Immunopath. 15, 397Google Scholar
  17. Cline, M. J., and V. C. Sweet (1968),J. Exp. Med. 128, 1309.PubMedGoogle Scholar
  18. Corradin, G., H. M. Etlinger, and J. M. Chillet (1977),J. Immunol. 119, 1048.PubMedGoogle Scholar
  19. DeLuca, D., G. Warr, and J. J. Marchalonis (1979),Immunogenetics 6, 359.Google Scholar
  20. Dickmeiss, E., B. Soeberg, and A. Svejgaard (1977),Nature 270, 526.PubMedGoogle Scholar
  21. Doherty, P. C., D. Solter, and B. B. Knowles (1977),Nature 266, 361.PubMedGoogle Scholar
  22. Dunham, E. K., E. R. Unanue, and B. Benacerraf (1972),J. Exp. Med. 136, 403.PubMedGoogle Scholar
  23. Edelman, G. M., I. Yahara, and J. L. Wang (1973),Proc. Natl. Acad. Sci. USA 70, 1442.PubMedGoogle Scholar
  24. Edidin, M., and A. Weiss (1972),Proc. Natl. Acad. Sci. USA 69, 2456.PubMedGoogle Scholar
  25. Effros, R. B., M. E. Frankel, W. Gerhard, and P. C. Doherty (1979),J. Immunol. 123, 1343.PubMedGoogle Scholar
  26. Eichmann, K. (1973),J. Exp. Med. 137, 603.PubMedGoogle Scholar
  27. Eichmann, K. (1974),Eur. J. Immunol. 4, 296.PubMedGoogle Scholar
  28. Eichmann, K., and K. Rajewsky (1975),Eur. J. Immunol. 5, 661.PubMedGoogle Scholar
  29. Eichmann, K., I. Falk, and K. Rajewski (1978),Eur. J. Immunol. 8, 853.PubMedGoogle Scholar
  30. Ellner, J. J., and A. S. Rosenthal (1975),J. Immunol. 144, 1563.Google Scholar
  31. Ellner, J. J., P. E. Lipsky, and A. S. Rosenthal (1977),J. Immunol. 118, 2053.PubMedGoogle Scholar
  32. Erb, P., and M. Feldman (1975),J. Exp. Med. 142, 460.PubMedGoogle Scholar
  33. Germain, R. N., S. T. Ju, T. J. Kipps, B. Benacerraf, and M. E. Dorf (1979),J. Exp. Med. 149, 613.PubMedGoogle Scholar
  34. Gershon, R. K., P. H. Maurer, and C. F. Merrvman (1973),Proc. Natl. Acad. Sci. USA 70, 250.PubMedGoogle Scholar
  35. Goldbsy, R., B. A. Osborne, E. Simpson, and I. A. Herzenberg (1977),Nature 267, 707.Google Scholar
  36. Goodman, J. W., S. Fong, G. K. Lewis, R. Kamin, D. E. Nitecki, and G. D. Balian (1978),Immunol. Rev. 39, 36.PubMedGoogle Scholar
  37. Goodman, J. W., G. K. Lewis, D. Primi, P. Hornback, and N. H. Ruddle (1980),Mol. Immunol.17, 933.PubMedGoogle Scholar
  38. Gordon, R. D., E. Simpson, and L. E. Samelson (1975),J. Exp. Med.142,1108.PubMedGoogle Scholar
  39. Goulmy, E., A. Termijtelen, B. A. Bradley, and J. J. Van Rood (1977),Nature 266, 544.PubMedGoogle Scholar
  40. Green, M. I., M. S. Sy, A. Nisonoff, and B. Benacerraf (1980),Mol. Immunol. 17, 857.Google Scholar
  41. Hale, A. H., O. N. Witte, D. Baltimore, and H. N. Eisen (1978),Proc. Natl. Acad. Sci. USA 75, 970.PubMedGoogle Scholar
  42. Harvey, M. A., L. Adorini, A. Miller, and E. E. Sercarz (1979),Nature 281, 594.PubMedGoogle Scholar
  43. Hammerling, G. J., and H. O. McDevitt (1974),J. Immunol. 112, 1726.PubMedGoogle Scholar
  44. Hashim, G. A., R. E. Sharpe, E. F. Carvalko, and L. E. Stevens (1976),J. Immunol. 116, 126.PubMedGoogle Scholar
  45. Hauptfeld, V., M. Hauptfeld, and J. Klein (1975),J. Exp. Med. 141, 1047.PubMedGoogle Scholar
  46. Henning, R., J. W. Schrader, and G. M. Edelman (1976),Nature 263, 689.PubMedGoogle Scholar
  47. Hood, L. (1976), inThe Role of Products of the Histocompatibility Gene Complex in Human Responses (Katz, D., and B. Benacerraf, eds.), Academic Press, New York, p. 703.Google Scholar
  48. Howie, S. (1977),Immunology 32, 301.PubMedGoogle Scholar
  49. Howie, S., M. Feldman, E. Moses, and P. H. Maurer (1977),Immunology 32, 291.PubMedGoogle Scholar
  50. Kapp, J. A., C. W. Pierce, S. Schlossman, and B. Benacerraf (1974),J. Exp. Med. 140, 648.PubMedGoogle Scholar
  51. Katz, D. H., and B. Benacerraf (1975),Transplant Rev.22, 175.PubMedGoogle Scholar
  52. Kennedy, L. J., Jr., M. E. Dorf, E. R. Unanue, and B. Benacerraf (1975),J. Immunol. 114, 1670.PubMedGoogle Scholar
  53. Kindred, B., and D. C. Shreffler (1972),J. Immunol. 109, 940.PubMedGoogle Scholar
  54. Klein, J. (1975),Biology of the Mouse Histocompatibility-2 Complex, Springer-Verlag, New York, p. 131.Google Scholar
  55. Kontiainen, S., E. Simpson, E. Bohrer, P. C. L. Beverly, L. A. Herzenberg, W. C. Fitzpatrick, P. Vogt, A. Torano, I. F. C. McKenzie, and M. Feldman (1978),Nature 274, 477.PubMedGoogle Scholar
  56. Koszinowski, U., and H. Ertle (1975),Nature 255, 552.PubMedGoogle Scholar
  57. Koszinowski, U., and R. Thomssen (1975),Eur. J. Immunol. 5, 245.PubMedGoogle Scholar
  58. Kunkel, H. G., M. Mannik, and R. C. Williams (1963),Science 140, 1218.PubMedGoogle Scholar
  59. Lewis, G. K., and J. W. Goodman (1978),J. Exp. Med. 148, 915.PubMedGoogle Scholar
  60. Lipskv, P. E., and A. S. Rosenthal (1975),J. Exp. Med. 141, 138.Google Scholar
  61. Lonai, P., and H. O. McDevitt (1974),J. Exp. Med. 140, 977.PubMedGoogle Scholar
  62. Longo, D. L., and R. H. Schwartz (1980),J. Exp. Med. 151, 1452.PubMedGoogle Scholar
  63. Luderer, A. A., D. M. Hess, and G. Odstrchel (1979),Mol. Immunol. 16, 777.PubMedGoogle Scholar
  64. Maizels, R. M., J. A. Clarke, M. A. Harvey, A. Miller, and E. E. Sercarz (1980),Eur. J. Immunol. 10, 509.PubMedGoogle Scholar
  65. Martin, J. W., P. H. Maurer, and B. Benacerraf (1971),J. Immunol. 107, 715.PubMedGoogle Scholar
  66. McDevitt, H. O., and M. Sela (1965),J. Exp. Med. 122, 517.PubMedGoogle Scholar
  67. McDevitt, H. O., D. C. Shreffler, and J. H. Stimpfling (1969),J. Clin. Invest. 48, 57a.Google Scholar
  68. McMichael, A. J., A. Ting, H. J. Zweerink, and B. A. Askonas (1977),Nature 270, 524.PubMedGoogle Scholar
  69. Merryman, C. F., P. H. Maurer, and J. H. Stimpfling (1975),Immunogenetics 2, 441.Google Scholar
  70. Mitchinson, N. A. (1969),Symp. Int. Soc. Cell. Biol. 7, 29.Google Scholar
  71. Mozes, E., and J. Haimovich (1979),Nature 278, 56.PubMedGoogle Scholar
  72. Muckerheide, A. A., A. J. Pesce, and G. J. Michael (1977),J. Immuno. 119, 1340.Google Scholar
  73. Nabholz, M., J. Vives, H. M. Young, T. Meo, V. Miggiano, A. Rijnbeck, and D. C. Shreffler (1974),Eur. J. Immunol. 4, 378.PubMedGoogle Scholar
  74. Nisonoff, A., and S. A. Bangasser (1975),Transplant. Rev. 27, 100.PubMedGoogle Scholar
  75. Nossal, G. J. V., N. L. Warner, H. Lewis, and J. Sprent (1972),J. Exp. Med. 135, 405.PubMedGoogle Scholar
  76. Oudin, J., and M. Michel (1963),C. R. Acad. Sci. (Paris) 257, 805.Google Scholar
  77. Owen, F. L., S. T. Ju, and A. Nisonoff (1977),J. Exp. Med. 14, 1559.Google Scholar
  78. Paul, W. E., and B. Benacerraf (1977),Science 195, 1293.PubMedGoogle Scholar
  79. Pawlak, L. L., E. B. Mushinski, A. Nisonoff, and M. Potter (1973),J. Exp. Med. 137, 22.PubMedGoogle Scholar
  80. Rabellino, E., S. Colon, H. M. Grey, and E. H. Unanue (1971),J. Exp. Med. 133, 156.PubMedGoogle Scholar
  81. Raff, M. C., M. Sternberg, and R. B. Taylor (1970),Nature 225, 553.PubMedGoogle Scholar
  82. Raff, M. C., and S. DePetris (1973),Fed. Proc. 32, 48.PubMedGoogle Scholar
  83. Roelants, G. E., A. Ryden, L. B. Hagg, and F. Loor (1974),Nature 247, 106.PubMedGoogle Scholar
  84. Rosentreich, D. L., and A. S. Rosenthal (1973),J. Immunol. 110, 934.Google Scholar
  85. Rosenthal, A. S., and E. Shevach (1973),J. Exp. Med. 138, 1194.PubMedGoogle Scholar
  86. Rosenthal, A. S., J. T. Blake, J. J. Ellner, D. K. Greineder, and P. E. Lipsky (1975), inImmune Recognition (Rosenthal, A. S., ed.), Academic Press, New York, p. 539.Google Scholar
  87. Ruddle, N. H., B. Beezlev, G. K. Lewis, and J. W. Goodman (1980),Mol. Immunol. 17, 925.PubMedGoogle Scholar
  88. Schlessinger, M., and M. Chaouat, (1975),Eur. J. Immunol. 5, 27.Google Scholar
  89. Schmidtke, J. R., and E. R. Unanue (1971),J. Immunol. 107, 331.PubMedGoogle Scholar
  90. Schrader, J. W., and G. M. Edelman (1977),J. Exp. Med. 145, 523.PubMedGoogle Scholar
  91. Schrader, J. W., B. A. Cunningham, and G. M. Edelman (1975),Proc. Natl. Acad. Sci. USA 72, 5066.PubMedGoogle Scholar
  92. Schwartz, R. H., and W. E. Paul (1976),J. Exp. Med. 143, 529.PubMedGoogle Scholar
  93. Schwartz, R. H.,; A. Yano, J. H. Stimpfling, and W. E. Paul (1979),J. Exp. Med. 149, 40.PubMedGoogle Scholar
  94. Seeger, R. C., and J. J. Oppenheim (1972),J. Immunol. 109, 255.PubMedGoogle Scholar
  95. Senik, A., and C. Neauport-Sautes (1979),J. Immunol. 122, 1461.PubMedGoogle Scholar
  96. Serendi, B., H. Y. Tse, C. Chen, and R. H. Schwartz (1981),J. Immunol. 126, 341.Google Scholar
  97. Shearer, G. M., A. M. Schmitt-Verhulst, and T. G. Rhen (1977),Contemp. Top. Immunobiol. 7, 221.PubMedGoogle Scholar
  98. Shevach, E. M. (1976),J. Immunol. 116, 1482.PubMedGoogle Scholar
  99. Slater, R. J., S. M. Ward, and H. G. Kunkel (1955),J. Exp. Med. 101, 85.PubMedGoogle Scholar
  100. Svedmyr, E., and M. Jondal (1975),Proc. Natl. Acad. Sci. USA 72, 1622.PubMedGoogle Scholar
  101. Swain, S., F. Modabber, and A. H. Coons (1976),J. Immunol. 116, 915.PubMedGoogle Scholar
  102. Swanborg, R. H. (1975),J. Immunol. 114, 191.PubMedGoogle Scholar
  103. Sweirkosz, J. E., and R. H. Swanborg (1975),J. Immunol. 115, 631.Google Scholar
  104. Taniguchi, M., K. Hayakawa, and T. Tada (1976),J. Immunol. 116, 542.PubMedGoogle Scholar
  105. Taniguchi, M., T. Sato, and T. Tada (1979),Nature 278, 555.PubMedGoogle Scholar
  106. Taylor, R. B., P. H. Duffus, M. C. Raff, and S. DePetris (1971),Nature (New Biol.) 233, 225.Google Scholar
  107. Turkin, D., and E. E. Sercarz (1977),Proc. Nat. Acad. Sci. USA 74, 3984.PubMedGoogle Scholar
  108. Tursz, T., W. H. Fridman, A. Senik, A. Tsapis, and M. Pellous (1977),Nature 269, 806.PubMedGoogle Scholar
  109. Unanue, E. R., and B. A. Askonas (1968),J. Exp. Med. 127, 915.PubMedGoogle Scholar
  110. Unanue, E. R., and J. C. Cerottini (1970),J. Exp. Med. 131, 711.PubMedGoogle Scholar
  111. Unanue, E. R., J. C. Cerottini, and M. Bedford (1969),Nature 222, 1193.PubMedGoogle Scholar
  112. Waldron, J. A., R. G. Horn, and A. S. Rosenthal (1973),J. Immunol. 111, 58.PubMedGoogle Scholar
  113. Warr, G. W., D. DeLuca, and J. J. Marchalonis (1979),Mol. Immunol. 16, 735.PubMedGoogle Scholar
  114. Watson, J. (1979),J. Exp. Med. 150, 1510.PubMedGoogle Scholar
  115. Woodland, R. T., and H. Cantor (1978),Eur. J. Immunol. 8, 600.PubMedGoogle Scholar
  116. Zinkernagel, R. M., and P. C. Doherty (1974),Nature 248, 701.PubMedGoogle Scholar
  117. Zinkernagel, R. M., and P. C. Doherty (1975),J. Exp. Med. 141, 1427.PubMedGoogle Scholar
  118. Zinkernagel, R. M., and P. C. Doherty (1977),Contemp. Top. Immunobiol. 7, 179.PubMedGoogle Scholar
  119. Zinkernagel, R. M., and M. B. A. Oldstone (1976),Proc. Natl. Acad. Sci. USA 73, 3666.PubMedGoogle Scholar
  120. Zinkernagel, R. M., A. Althage, B. Adler, R. V. Blanden, W. F. Davidson, U. Kees, M. B. C. Dunlop, and D. C. Shreffler (1977),J. Exp. Med. 145, 1353.PubMedGoogle Scholar
  121. Zweerink, H. J., S. A. Courtneidge, J. J. Skehel, M. J. Crumpton, and B. A. Askonas (1977),Nature 267, 354.PubMedGoogle Scholar

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© The Humana Press Inc. 1982

Authors and Affiliations

  • Albert A. Luderer
    • 1
  • Michael A. Harvey
    • 1
  1. 1.Biosciences Research Department, Research and Development DivisionCorning Glass WorksCorningUSA

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