Abstract
Because their differentiated forms are very complex and highly interrelated, neurons are likely to require considerable information about their environment as they develop. Each neuron acquires very specific biophysical, biochemical, and morphological properties, and a specific set of synaptic connections which are essential for its ultimate functioning. For example, each neuron sends axonal processes over large distances, upon very precise pathways, to reach specific targets (eg Lance-Jones and Landmesser, 1981; Raper et al, 1982a,b). The growth cones that accomplish these tasks must interact with their environment in such a way that they can distinguish the proper pathways upon which to elongate, the proper locations at which to branch, and the proper targets upon which to synapse. These considerations imply that some form of cell to cell communications must play a decisive role in neuronal development.
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Raper, J.A., Goodman, C.S. (1982). Transient Dye Coupling Between Developing Neurons Reveals Patterns of Intercellular Communication During Embryogenesis. In: Sheffield, J.B., Hilfer, S.R. (eds) Cellular Communication During Ocular Development. Cell and Developmental Biology of the Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5764-6_6
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DOI: https://doi.org/10.1007/978-1-4612-5764-6_6
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