Activity of the Antibiotics
The activity of an antibiotic is defined and measured in terms of its capacity to inhibit microbial growth (bacteria, fungi, protozoa). Although the concept of growth is familiar as applied to macroscopic organisms (irreversible increase in volume as a function of time), it must be redefined to take into account microscopic organisms, because in this case two different levels of growth can be distinguished: population growth and growth of a single cell. By population growth we mean the increase with time of the number of microorganisms, i.e., the increase in the density of the microbial population. By cell growth we mean the synthesis of cellular material needed for one cell to give rise to two daughter cells. Obviously, the growth of the microbial population is the result of cell growth.
KeywordsMinimal Inhibitory Concentration Inoculum Size Minimal Bactericidal Concentration Antibiotic Activity Inoculum Density
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