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Hematologic Aspects of Arterial Hypertension

  • A. B. Gould

Abstract

Various hematologic disorders are associated with hypertension. These include the anemia of malignant hypertension; polycythemia associated with nonneoplastic renal disease such as hydronephrosis, polycystic kidney disease, renal artery stenosis; and relative or benign polycythemia, sometimes called Gaisbock syndrome. This chapter will describe these conditions and the methods which are used to treat them.

Keywords

Renal Artery Stenosis Polycystic Kidney Disease Thrombotic Thrombocytopenic Purpura Polycythemia Vera Malignant Hypertension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Babb AL, Popovich RP, Christopher TG, Scribner BH (1971) The genesis of the square meter-hour hypothesis. Trans Am Soc Artif Int Organs 17: 81Google Scholar
  2. 2.
    Baker LRI, Rubenberg ML, Dacie JV, Brain MC (1968) Fibrinogen catabolism in microangiopathic haemolytic anaemia. Brit J Haematol 14: 617CrossRefGoogle Scholar
  3. 3.
    Berman LB (1973) Does renin stimulate the formation of erythropoietin? In: Sambhi MP (ed) Mechanisms of Hypertension. American Elsevier, New York, p 249Google Scholar
  4. 4.
    Bläker F, Altrogge H, Hellwege HH, Menke B, Thimm K (1978) Dialysebehandlung des schweren hämolytisch-urämischen Syndroms. Dtsch Med Wschr 103: 1229PubMedCrossRefGoogle Scholar
  5. 5.
    Blum AS, Zbar MJ (1959) Relative polycythemia. Alterations of red cell distribution simulating hemocon- centration. Arch Intern Med 104: 385Google Scholar
  6. 6.
    Bourgoignie JJ, Gallagher NI, Perry HM Jr, Kurz L, Warnecker MA, Donati RM (1968) Renin and erythropoietin in normotensive and in hypertensive patients. J Lab Clin Med 71: 523PubMedGoogle Scholar
  7. 7.
    Brain MC (1968) Haemolytic-uraemic syndrome. Lancet 2: 1394PubMedCrossRefGoogle Scholar
  8. 8.
    Brain MC, Dacie JV, Hourihane DO (1962) Microangiopathic haemolytic anaemia: The possible role of vascular lesions in pathogenesis. Brit J Haematol 8: 358Google Scholar
  9. 9.
    Brown SM, Gilbert HS, Krauss S, Wasserman LR (1971) Spurious (relative) polycythemia: A nonexistent disease. Am J Med 50: 200Google Scholar
  10. 10.
    Bull BS, Rubenberg ML, Dacie JV, Brain MC (1968) Microangiopathic haemolytic anaemia: Mechanisms of red cell fragmentation: In vitro studies. Brit J Haematol 14: 643Google Scholar
  11. 11.
    Capelli, JP, Wesson LG Jr, Erslev AV (1966) Malignant hypertension and red cell fragmentation syndrome. Ann Intern Med 64: 128PubMedGoogle Scholar
  12. 12.
    Chrysant SG, Fröhlich ED, Adamopoulous PN, Stein PD, Whitcomb WH, Allen W, Neller G (1976) Patho-physiologic significance of “stress” or relative polycythemia in essential hypertension. Am J Cardiol 37: 1069PubMedCrossRefGoogle Scholar
  13. 13.
    Cooper RA (1970) The pathogenesis of burr cells in uremia. J Clin Invest 49: 22aGoogle Scholar
  14. 14.
    Cooper WM, Tuttle WB (1957) Polycythemia associated with a benign kidney lesion: Report of a case of erythrocytosis with hydronephrosis, with remission of polycythemia following nephrectomy. Ann Intern Med 47: 1008Google Scholar
  15. 15.
    Cunningham FG, Pritchard JA (1978) Hematologic considerations of pregnancy-induced hypertension. Semin Perinatol 2: 29PubMedGoogle Scholar
  16. 16.
    Dacie JV (1960) The Haemolytic Anaemias: Congenital and Acquired. Grune & Stratton, New York, 1960Google Scholar
  17. 17.
    Davidson EC Jr, Phillips LL (1972) Coagulation studies in the hypertensive toxemias of pregnancy. Am J Obstet Gynecol 113: 905PubMedGoogle Scholar
  18. 18.
    Ekberg M, Nilsson IM, Hedner U, Moqvist I, Bergentz S, Denneberg T (1974) Renal artery occlusion, malignant hypertension and thrombotic thrombocytopenic purpura. Acta Med Scand 195: 499PubMedCrossRefGoogle Scholar
  19. 19.
    Emery AC Jr, Whitcomb WH, Fröhlich ED (1974) “Stress” polycythemia and hypertension. JAMA 229:159Google Scholar
  20. 20.
    Erslev A (1969) Erythropoietic function of the kidney. In: Wesson LG Jr (ed) Physiology of the Human Kidney. Grune & Stratton, New York, p 521Google Scholar
  21. 21.
    Eschbach JW Jr, Funk D, Adamson J, Kuhn I, Scribner BH, Finch A (1967) Erythropoiesis in patients with renal failure undergoing chronic dialysis. N Engl J Med 276: 653PubMedCrossRefGoogle Scholar
  22. 22.
    Fisher ER, Pardo V, Paul R, Hayashi TT (1969) Ultrastructural studies in hypertension: IV. Toxemia of pregnancy. Am J Pathol 55: 109Google Scholar
  23. 23.
    Fisher JW, Lertora JJL, Lindholm DD, Tornyos K, Moriyama Y (1973) Erythropoietin production and inhibitors in serum in the anemia of uremia. Proc Clin Dial Transp Forum 3: 22Google Scholar
  24. 24.
    Gaisböck F (1905) Die Bedeutung der Blutdruckmessung für die ärztliche Praxis. Dtsch Arch Klin Med 83: 363Google Scholar
  25. 25.
    Gallagher NI, McCarthy JM, Lange RD (1960) Observations on erythropoietic-stimulating factor ( ESF) in the plasma of uremic and non-uremic patients. Ann Intern Med 52: 1201Google Scholar
  26. 26.
    Gardner FH, Freymann JG (1958) Erythrocythemia (polycythemia) and hydronephrosis: Report of a case with radio-iron studies, with recovery after nephrectomy. N Engl J Med 259: 323Google Scholar
  27. 27.
    Gavras H, Brown WCB, Brown JJ, Lever AF, Linton AL, MacAdam RF, McNicol GP, Robertson JIS, Wardrop C (1971) Microangiopathic hemolytic anemia and the development of the malignant phase of hypertension. Circ Res 28 and 29 (Suppl. 2): II - 127Google Scholar
  28. 28.
    Gavras H, Oliver N, Aitchison J, Begg C, Briggs JD, Brown JJ, Horton PW, Lee F, Lever AF, Prentice C, Robertson JIS (1975) Abnormalities of coagulation and the development of malignant phase hypertension. Kidney Int 8:S-252Google Scholar
  29. 29.
    Giesa J (1973) Renin, angiotensin and hypertensive vascular damage: A review. Am J Med 55: 315CrossRefGoogle Scholar
  30. 30.
    Hall CA (1965) Gaisböck’s disease: Redefinition of an old syndrome. Arch Intern Med 116: 4PubMedCrossRefGoogle Scholar
  31. 31.
    Hudgson P, Pearce JMS, Yeates WK (1967) Renal artery stenosis with hypertension and high haematocrit. Brit Med J 1: 18PubMedCrossRefGoogle Scholar
  32. 32.
    Jones NF, Payne RW, Hyde RD, Price TML (1960) Renal polycythaemia. Lancet 1: 299PubMedCrossRefGoogle Scholar
  33. 33.
    Kaung DT, Peterson RE (1962) “Relative polycythemia” or “pseudopolycythemia.” Arch Intern Med 110: 456PubMedGoogle Scholar
  34. 34.
    Kincaid-Smith P (1972) Coagulation and renal disease. Kidney Int 2: 183PubMedCrossRefGoogle Scholar
  35. 35.
    Kincaid-Smith P, McMichael J, Murphy EA (1958) The clinical course and pathology of hypertension with papilledema (malignant hypertension). Quart J Med 27: 117PubMedGoogle Scholar
  36. 36.
    Krauss S, Wasserman LR (1972) Spurious (relative) polycythemia. In: Williams WJ (ed) Hematology. McGraw-Hill, New York, p 555Google Scholar
  37. 37.
    Kurrle GR (1954) A case of Gaisböck’s disease (polycythaemia hypertonica). Med J Aust 1: 777Google Scholar
  38. 38.
    Lawrence JH, Berlin NI (1952) Relative polycythemia—the polycythemia of stress. Yale J Biol Med 24: 498PubMedGoogle Scholar
  39. 39.
    Lawrence JH, Donald WG Jr (1959) Polycythemia and hydronephrosis of renal tumors. Ann Intern Med 50: 959PubMedGoogle Scholar
  40. 40.
    Lindholm DD, Pace RL, Russell HH Jr (1969) Anemia of uremia responsive to increased dialysis treatment. Trans Am Soc Artif Int Organs 15: 360Google Scholar
  41. 41.
    Linton AL, Gavras H, Gleadle RI, Hutchison HE, Lawson DH, Lever AF, MacAdam RF, McNicol GP, Robertson JIS (1969) Microangiopathic haemolytic anaemia and the pathogenesis of malignant hypertension. Lancet 1: 1277PubMedCrossRefGoogle Scholar
  42. 42.
    Luke RG, Kennedy AC, Stirling WB, McDonald GA (1965) Renal artery stenosis, hypertension and poly-cythaemia. Brit Med J 1: 164PubMedCrossRefGoogle Scholar
  43. 43.
    Mann DL, Donati RM, Gallagher NI (1965) Erythropoietin assay and ferrokinetic measurements in anemic uremic patients. JAMA 194: 153CrossRefGoogle Scholar
  44. 44.
    Markson JL, Rennie JB (1956) The anaemia of chronic renal insufficiency. The effect of serum from azotaemic patients on the maturation of normoblasts in suspension cultures. Scot Med J 1: 320Google Scholar
  45. 45.
    Mel’nikov AF (1963) State of blood coagulation at different stages in arterial hypertension. Fed Proc (22 Trans Suppl.) T74Google Scholar
  46. 46.
    Mirand EA, Murphy GP (1969) Erythropoietin alterations in patients with uremia, renal allografts, or without kidneys. JAMA 209: 392PubMedCrossRefGoogle Scholar
  47. 47.
    Mitchell TR (1977) Diseases of the urinary system: Treatment of blood disorders in renal disease and renal failure. Brit Med J 2: 174PubMedCrossRefGoogle Scholar
  48. 48.
    Neff MS, Kim KE, Persoff M, Onesti G, Swartz C (1971) Hemodynamics of uremic anemia. Circulation 43: 876PubMedGoogle Scholar
  49. 49.
    Nixon RK, O’Rourke W, Rupe CE, Korst DR (1960) Nephrogenic polycythemia. Arch Intern Med 106: 797PubMedGoogle Scholar
  50. 50.
    Raghupathy P, Date A, Shastry JCM, Sudarsanam A, Jadhav M (1978) Haemolytic-uraemic syndrome complicating shigella dysentery in South Indian children. Brit Med J 1: 1518PubMedCrossRefGoogle Scholar
  51. 51.
    Regoeczi E, Rubenberg ML, Brain MC (1967) Intravascular haemolysis and disseminated intravascular coagulation. Lancet 1: 601PubMedCrossRefGoogle Scholar
  52. 52.
    Rubenberg ML, Regoeczi E, Bull BS, Dacie JV, Brain MC (1968) Microangiopathic haemolytic anaemia: The experimental production of haemolysis and red- cell fragmentation by defibrination in vivo. Brit J Haematol 14: 627Google Scholar
  53. 53.
    Russell RP, Conley CL (1961) Benign polycythemia: Gaisböck’s syndrome. Arch Intern Med 114: 734Google Scholar
  54. 54.
    Sevitt LH, Naish P, Baker LRI, Bulpitt CJ, Archer DFJ, Nelson DA, Peters DK (1973) The significance of microangiopathic haemolytic anaemia in accelerated hypertension. Brit J Haematol 24: 503CrossRefGoogle Scholar
  55. 55.
    Stefanini M, Urbas JV, Urbas JE (1978) Gaisböck’s syndrome: Its hematologic, biochemical and hormonal parameters. Angiology 29: 520Google Scholar
  56. 56.
    Stewart JH (1967) Haemolytic anaemia in acute and chronic renal failure. Quart J Med 36: 85Google Scholar
  57. 57.
    Tarazi RC, Fröhlich ED, Dustan HP, Gifford RW Jr, Page IH (1966) Hypertension and high hematocrit: Another clue to renal arterial disease. Am J Cardiol 18: 855Google Scholar
  58. 58.
    Urbanyuk KG (1963) Prethrombotic tendency in arterial hypertension. Fed Proc (22 Trans Suppl.) T 76Google Scholar
  59. 59.
    Wallner SF, Kurnick JE, Ward HP, Vautrin R, Alfrey AC (1976) The anemia of chronic renal failure and chronic diseases: In vitro studies of erythropoiesis. Blood 47: 561Google Scholar
  60. 60.
    Wardle EN (1976) The functional role of intravascular coagulation in renal disease. Scot Med J 21: 83PubMedGoogle Scholar
  61. 61.
    Whitaker AN, Bunce I, Nicoli P, Bowling SV (1973) Interaction of angiotensin with disseminated intravascular coagulation: A possible mechanism in the genesis of acute renal failure. Am J Pathol 72: 1Google Scholar
  62. 62.
    Wilkinson R, Scott DF, Uldall PR, Kerr DNS, Swinney J (1970) Plasma renin and exchangeable sodium in the hypertension of chronic renal failure. Quart J Med 39: 377PubMedGoogle Scholar
  63. 63.
    Wodzicki AM, Coopland AT (1977) Coagulation and the hypertensive diseases of pregnancy. Am J Obstet Gynecol 129: 393PubMedGoogle Scholar

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© Springer-Verlag New York, Inc. 1982

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  • A. B. Gould

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