Characterization and Isolation of Dopamine-Binding Proteins in Rat CNS by Gel Electrophoresis & Affinity Chromatography
During the last decade, neurotransmitter receptors in the central nervous system have received considerable attention from investigators in search of unknown factors that may be involved in the etiology of various neurological and psychiatric disorders. In particular, dopamine (DA) receptors have been shown to be related to tardive dyskinesia (Baldessarini and Tarsey, 1980; Creese and Snyder, 1980 and Jeste and Wyatt, 1981), Parkinson’s disease (Lee et al., 1981 and Rinne, et al., 1981), Huntington’s Chorea (Login et al., 1982) and schizophrenia (Crow et al., 1978; Lee et al., 1978; Lee and Seeman, 1980; and Mackay et al., 1980).
KeywordsDopamine Receptor Tardive Dyskinesia Corpus Striatum Synaptosomal Fraction Sodium Borate Buffer
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