H-2 Class I and Class II Alloantigens as Triggering Stimuli of Suppressor T Cells
H-2 alloantigens induce a population of splenic suppressor T cells (MLR-Ts) following in vivo sensitization with H-2 allogeneic cells. After in vitro restimulation with cells of the priming haplotype Ts produce a suppressor factor (MLR-TsF) that inhibits T cell proliferation in MLR. MLR-Ts as a population express I-J and I-C antigens (1), and I-C, but not I-J determinants are found as components of MLR-TsF (2). In contrast, the specific H-2 alloantigens that are required to prime and subsequently trigger MLR-Ts have only recently been investigated, and are the focus of this report.
KeywordsRecombination Allo Mitomycin
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