Ir Genes pp 497-501 | Cite as

H-2 Class I and Class II Alloantigens as Triggering Stimuli of Suppressor T Cells

  • Susan Rich
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)

Abstract

H-2 alloantigens induce a population of splenic suppressor T cells (MLR-Ts) following in vivo sensitization with H-2 allogeneic cells. After in vitro restimulation with cells of the priming haplotype Ts produce a suppressor factor (MLR-TsF) that inhibits T cell proliferation in MLR. MLR-Ts as a population express I-J and I-C antigens (1), and I-C, but not I-J determinants are found as components of MLR-TsF (2). In contrast, the specific H-2 alloantigens that are required to prime and subsequently trigger MLR-Ts have only recently been investigated, and are the focus of this report.

Keywords

Recombination Allo Mitomycin 

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References

  1. 1.
    Rich, S. and David, C. (1979) J. Exp. Med. 150: 1108–1121.PubMedCrossRefGoogle Scholar
  2. 2.
    Rich, S., David, C. and Rich, R. (1979) J. Exp. Med. 149: 114–126.PubMedCrossRefGoogle Scholar
  3. 3.
    Dennison, D., Rich, S. and Rich, R. (1981) J. Immunol. 127: 2176–2182.PubMedGoogle Scholar
  4. 4.
    Swain, S., Dennert, G., Wormsley, S. and Dutton, R. (1981) Eur. J. Immunol. 11:175–180.PubMedCrossRefGoogle Scholar
  5. 5.
    Larsson, E., Iscove, N. and Coutinho, A. (1980) Nature 283:664–665.PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Susan Rich
    • 1
  1. 1.Baylor College of MedicineHoustonUSA

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