Advertisement

Ir Genes pp 433-437 | Cite as

Functional Evidence for Two Antigen Presentation Sites for a Single I-A Molecule

  • Patricia A. Nelson
  • Barbara N. Beck
  • C. Garrison Fathman
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)

Abstract

The recognition of soluble antigen by T cells has been shown to be restricted by la molecules on antigen-presenting cells (APC). Utilizing complementary pairs of T cell helper clones reactive with the synthetic terpolymer GAT (glutamic acid60-alanine30-tyrosine10) derived from (C57BL/6x A/J)F1 mice (B6A), it has been possible to show that there exist at least two separate antigen restriction/presentation sites per I-A molecule.

The mouse major histocompatibility complex has long been thought to regulate many aspects of the immune response. It is now known that I region gene products are no longer just associated with immune responses: the products are the actual proteins involved in the genetically restricted reactions between T cells and macrophages (1). Proliferative T cells respond in vitro to antigen only in the context of I-A or I-E region gene products on antigen presenting cells (2,3). Antigen-reactive T cell clones derived from F1 mice have been shown to be restricted by I region products from either parental strain or, in some cases, to a unique antigen presenting determinant present only in F1 mice (2,3).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Beck, B.N., Frelinger, J.G., Shigeta, M., Infante, A.J., Cummings, D., Hammerling, G. and Fathman, C.G. 1982. J. Exp. Med. (in press).Google Scholar
  2. 2.
    Kimoto, M. and Fathman, C.G. 1980. J. Exp. Med. 152:759.PubMedCrossRefGoogle Scholar
  3. 3.
    Fathman, C.G. and Kimoto, M. 1981. Immunological Rev. 54:57.CrossRefGoogle Scholar
  4. 4.
    Oi, V.T., Jones, P.P., Goding, J.W., Herzenberg, L.A. and Herzenberg, L.A. 1978. Curr. Topics Microbiol. Immun. 81:115.Google Scholar
  5. 5.
    Hammerling, G.J., Hammerling, U. and Lernke, H. 1979. Immunogenetics 8:433.CrossRefGoogle Scholar
  6. 6.
    Symington, F.W. and Sprent, J. 1981. Immunogenetics 14:53.PubMedCrossRefGoogle Scholar
  7. 7.
    Melvold, R.W. and Kohn, H.I. 1976. Immunogenetics 3:185.CrossRefGoogle Scholar
  8. 8.
    McKenzie, I.F.C., Morgan, G.M., Sandrin, M.S., Michaelides, M.M., Melvold, R.W. and Kohn, H.I. 1979. J. Exp. Med. 150:1323.PubMedCrossRefGoogle Scholar
  9. 9.
    McKean, D.J., Melvold, R.W. and David, C. 1981. Immunogenetics 14:41.PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Patricia A. Nelson
    • 1
    • 2
  • Barbara N. Beck
    • 1
    • 2
  • C. Garrison Fathman
    • 1
    • 2
  1. 1.Stanford UniversityStanfordUSA
  2. 2.Mayo Medical SchoolRochesterUSA

Personalised recommendations