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Ir Genes pp 39–43Cite as

Enhancement of Murine T Cell I-J Expression by Limited Proteolysis

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Part of the book series: Experimental Biology and Medicine ((EBAM,volume 4))

Abstract

The I-J subregion of the murine H-2 complex encompasses a locus controlling suppressor T lymphocyte determinants, Ia-4 (1). I-J molecules also demarcate a helper T cell subset (1), macrophages required for in vitro antibody production (2) and T cells initiating response to Con A (3). Antigen-specific suppressor T cell factors also bear I-J determinants. Much biochemical information is known about these soluble proteins. Little is known about the biochemistry of cellular I-J products. Direct visualization of these molecules is difficult, and their isolation has not been reported. Lymphocyte proteolysis offers one means of studying cellular I-J biochemistry.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, College of Agricultural & Life Sciences, University of Wisconsin, Madison, Wisconsin, 53706, USA

    Karen Klyczek, Debra Hullett & Colleen Hayes

Authors
  1. Karen Klyczek
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  2. Debra Hullett
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  3. Colleen Hayes
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, St. Louis, Missouri, USA

    Carl W. Pierce  & Judith A. Kapp  & 

  2. Department of Microbiology and Immunology, Washington University, St. Louis, Missouri, USA

    Susan E. Cullen

  3. Howard Hughes Medical Institute Laboratory and the Departments of Medicine (Div. of Rheumatology) and Microbiology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

    Benjamin D. Schwartz

  4. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA

    Donald C. Shreffler

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© 1983 The Humana Press Inc.

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Klyczek, K., Hullett, D., Hayes, C. (1983). Enhancement of Murine T Cell I-J Expression by Limited Proteolysis. In: Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D., Shreffler, D.C. (eds) Ir Genes. Experimental Biology and Medicine, vol 4. Humana Press. https://doi.org/10.1007/978-1-4612-5633-5_6

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  • DOI: https://doi.org/10.1007/978-1-4612-5633-5_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-5635-9

  • Online ISBN: 978-1-4612-5633-5

  • eBook Packages: Springer Book Archive

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