Ir Genes pp 361-365 | Cite as

Immune Response Gene Effects in Cytotoxic T Cell Responses as a Consequence of Self Tolerance

  • Arno Müllbacher
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)


The strength of the immune response to a variety of antigens is controlled by immune response (Ir) genes, most of which are linked to the major histocompatibility complex (H-2 in the mouse). The classical experiments on Ir gene control and function involved T cell proliferative, as well as T helper (Th), cell responses. Ir genes influencing these responses were mapped to the I region of H-2. The induction of such T cell responses were later found to be restricted by I region-coded antigens (1).


Major Histocompatibility Complex Cell Repertoire Vaccinia Response Tolerance Model Antigenic Mimicry 
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Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Arno Müllbacher
    • 1
  1. 1.Department of Microbiology, John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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