Immune Response Gene Effects in Cytotoxic T Cell Responses as a Consequence of Self Tolerance
The strength of the immune response to a variety of antigens is controlled by immune response (Ir) genes, most of which are linked to the major histocompatibility complex (H-2 in the mouse). The classical experiments on Ir gene control and function involved T cell proliferative, as well as T helper (Th), cell responses. Ir genes influencing these responses were mapped to the I region of H-2. The induction of such T cell responses were later found to be restricted by I region-coded antigens (1).
KeywordsDepression Meningitis Vaccinia
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