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Ir Genes pp 361-365 | Cite as

Immune Response Gene Effects in Cytotoxic T Cell Responses as a Consequence of Self Tolerance

  • Arno Müllbacher
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)

Abstract

The strength of the immune response to a variety of antigens is controlled by immune response (Ir) genes, most of which are linked to the major histocompatibility complex (H-2 in the mouse). The classical experiments on Ir gene control and function involved T cell proliferative, as well as T helper (Th), cell responses. Ir genes influencing these responses were mapped to the I region of H-2. The induction of such T cell responses were later found to be restricted by I region-coded antigens (1).

Keywords

Major Histocompatibility Complex Cell Repertoire Vaccinia Response Tolerance Model Antigenic Mimicry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Arno Müllbacher
    • 1
  1. 1.Department of Microbiology, John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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