Abstract
The initial observations that determinants controlled by the I-J subregion are expressed on allotype suppressor T cells (1) and are associated with a soluble T cell derived suppressor mediator (2) has stimulated a great deal of investigative work on this segment of chromosome (reviewed in 3,4). Determinants controlled by the I-J subregion and defined by alloantibody are expressed on 1) T cell subsets (Ly-l+,2-; Ly-l+,2+; Ly-l-,2+) and solubile mediators involved in the generation of suppressor activity (5,6,7); 2) a helper T cell subset (Ly-l+,2-) (8); 3) T cell subsets (Ly-l+,2-; Ly- l+,2+; Ly-l-,2+) and a soluble mediator involved in the generation of contrasuppressor activity (9); 4) some cytotoxic T lymphocytes (10); and 5) a non-T-non-B (macrophage) cell subset involved in the generation of humoral responses (11,12).
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Horowitz, M.C., Murphy, D.B. (1983). Induction of Autoreactive T Cells by Stimulation Across the I-J Subregion. In: Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D., Shreffler, D.C. (eds) Ir Genes. Experimental Biology and Medicine, vol 4. Humana Press. https://doi.org/10.1007/978-1-4612-5633-5_5
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DOI: https://doi.org/10.1007/978-1-4612-5633-5_5
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