Abstract
Two models to explain the cellular site and mechanism of expression of MHC linked immune response (Ir) genes are currently popular. One model holds that the immune response gene is expressed as a defect in the T cell receptor repertoire such that T cells from nonresponder animals are unable to recognize antigens under Ir gene control in the context of self MHC antigens and, thus, are not stimulated. However, the same antigen may be recognized in the context of allo-MHC components under conditions where alloreactivity has been abolished. Ample experimental evidence exists in the literature to support this model (1–4). The alternative model to explain Ir gene function, the determinant selection hypothesis, centers around the concept that antigen presenting cells from nonresponder animals fail to display foreign antigenic determinants in the proper array with self MHC determinants. Again, ample experimental evidence is available to support this model (5–8).
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Pierce, C.W., Kapp, J.A. (1983). Antigen-Specific Suppressor T Cells as One Mode of Expression of Immune Response Genes. In: Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D., Shreffler, D.C. (eds) Ir Genes. Experimental Biology and Medicine, vol 4. Humana Press. https://doi.org/10.1007/978-1-4612-5633-5_44
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DOI: https://doi.org/10.1007/978-1-4612-5633-5_44
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