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Murine T Cell-Specific IA Antigens: Helper T Lymphocytes Express a Unique I-A-Encoded Molecule

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Ir Genes

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 4))

Abstract

Genetic and environmental influences determine an animal’s capacity to respond immunologically to a foreign stimulus. The murine major histocompatibility complex (H-2) linked immune response (Ir) genes provide a model wherein the molecular basis for immune regulation can be examined (1). Cellular interactions, cell-mediated antiviral immunity, self-nonself discrimination, and immune suppression are H-2I region controlled traits (1).

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References

  1. Benacerraf, B. & Germain, R. (1978) Immunol. Rev. 38, 70–119.

    Article  PubMed  CAS  Google Scholar 

  2. Uhr, J. W., Capra, J. D., Vitetta, E. S. & Cook, R. G. (1979) Science 206, 292–297.

    Article  PubMed  CAS  Google Scholar 

  3. David, C. S., Meo, T., McCormick, J. & Shreffler, D. C. (1976) J. Exp. Med. 143, 218–224.

    Article  PubMed  CAS  Google Scholar 

  4. Goding, J. W., White, E. & Marchalonis, J. J. (1975) Nature (London) 257, 230–231.

    Article  CAS  Google Scholar 

  5. Oi, V. T., Jones, P. P., Goding, J. W., Herzenberg, L. A. & Herzenberg, L. A. (1979) in Lymphocyte Hybridomas, eds. Melchers, F., Potter, M. & Warner, N. (Springer, New York) pp. 115–129.

    Google Scholar 

  6. Ozato, K., Mayer, N. & Sachs, D. H. (1980) J. Immunol. 124, 533–540.

    PubMed  CAS  Google Scholar 

  7. Hämmerling, G. J., Hämmerling, U. & Lemke, H. (1979) Immunogenetics (N.Y.) 8, 433–445.

    Article  Google Scholar 

  8. Schwartz, R. H., Yano, A., and Paul, W. E. (1978) Immunological Rev. 40, 153–180.

    Article  CAS  Google Scholar 

  9. Murphy, D. B. (1978) Springer Seminars Immunopathol. 1, 111–131.

    Google Scholar 

  10. Okumura, K., Herzenberg, L. A., Murphy, D. B., McDevitt, H. O. & Herzenberg, L. A. (1976) J. Exp. Med. 144, 685–698.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin, 53706, USA

    Colleen E. Hayes, Robert M. Whitcomb, David P. Krum, Karen K. Klyczek & Debra A. Hullett

Authors
  1. Colleen E. Hayes
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  2. Robert M. Whitcomb
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  3. David P. Krum
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  4. Karen K. Klyczek
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  5. Debra A. Hullett
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, St. Louis, Missouri, USA

    Carl W. Pierce  & Judith A. Kapp  & 

  2. Department of Microbiology and Immunology, Washington University, St. Louis, Missouri, USA

    Susan E. Cullen

  3. Howard Hughes Medical Institute Laboratory and the Departments of Medicine (Div. of Rheumatology) and Microbiology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

    Benjamin D. Schwartz

  4. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA

    Donald C. Shreffler

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© 1983 The Humana Press Inc.

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Hayes, C.E., Whitcomb, R.M., Krum, D.P., Klyczek, K.K., Hullett, D.A. (1983). Murine T Cell-Specific IA Antigens: Helper T Lymphocytes Express a Unique I-A-Encoded Molecule. In: Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D., Shreffler, D.C. (eds) Ir Genes. Experimental Biology and Medicine, vol 4. Humana Press. https://doi.org/10.1007/978-1-4612-5633-5_2

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  • DOI: https://doi.org/10.1007/978-1-4612-5633-5_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-5635-9

  • Online ISBN: 978-1-4612-5633-5

  • eBook Packages: Springer Book Archive

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