Skip to main content
SpringerLink
Log in

Quantitation of Ia Antigens on Normal and Leukemic Human Lymphocytes

  • Chapter
Ir Genes

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 4))

  • 43 Accesses

Abstract

The number of Ia molecules accessible at the surface of a cell could be related to the stage of differentiation and to the functional status of that cell. We have measured the level of Ia expressed on various normal and leukemic human lymphocytes using monoclonal antibody 21w4 which recognizes a non-polymorphic epitope of human Ia (1,2). Our results with ALL and CLL do not support a correlation between stage of differentiation and level of Ia. Furthermore PHA-activated T cells and tonsillar B cells express the highest amounts of Ia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Addis, J.B.L., Tisch, R., Falk, J.A. and Letarte, M. (1982) J. Immunol., in press.

    Google Scholar 

  2. Letarte, M. and Falk, J. (1982) J. Immunol., 128, 217.

    PubMed  CAS  Google Scholar 

  3. Okamura, J., Gelfand, E.W. and Letarte, M. (1982) Blood, in press.

    Google Scholar 

  4. Okamura, J., Letarte, M. and Gelfand, E.W. (1982) Submitted to Blood.

    Google Scholar 

  5. Letarte, M., Teh, H.-S. and Meghji, G. (1980) J. Immunol., 125, 370.

    PubMed  CAS  Google Scholar 

  6. Shackelford, D.A. and Strominger, J.L. (1980). J. Exp. Med., 151, 144.

    Article  PubMed  CAS  Google Scholar 

  7. Shackelford, D.A., Mann, D.L., van Rood, J.J., Ferrara, G.B. and Strominger, J.L. (1981) Proc. Natl. Acad. Sci. USA 78, 4566.

    Article  PubMed  CAS  Google Scholar 

  8. de Kretser, T.A., Crumpton, M.J., Bodmer, J.G. and Bodmer, W.F. (1982) Eur. J. Immunol., 12, 214.

    Article  PubMed  Google Scholar 

  9. de Kretser, T.A., Crumpton, M.J., Bodmer, J.G. and Bodmer, W.F. (1982) Eur. J. Immunol., in press.

    Google Scholar 

  10. Goyert, S.M., Shively, J.E. and Silver, J. (1982). J. Exp. Med., in press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunology, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Canada, M5G 1X8

    Michelle Letarte, Jun Okamura, Jane B. L. Addis, Roland Tisch & Erwin W. Gelfand

Authors
  1. Michelle Letarte
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jun Okamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jane B. L. Addis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roland Tisch
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Erwin W. Gelfand
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, St. Louis, Missouri, USA

    Carl W. Pierce  & Judith A. Kapp  & 

  2. Department of Microbiology and Immunology, Washington University, St. Louis, Missouri, USA

    Susan E. Cullen

  3. Howard Hughes Medical Institute Laboratory and the Departments of Medicine (Div. of Rheumatology) and Microbiology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

    Benjamin D. Schwartz

  4. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA

    Donald C. Shreffler

Rights and permissions

Reprints and permissions

Copyright information

© 1983 The Humana Press Inc.

About this chapter

Cite this chapter

Letarte, M., Okamura, J., Addis, J.B.L., Tisch, R., Gelfand, E.W. (1983). Quantitation of Ia Antigens on Normal and Leukemic Human Lymphocytes. In: Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D., Shreffler, D.C. (eds) Ir Genes. Experimental Biology and Medicine, vol 4. Humana Press. https://doi.org/10.1007/978-1-4612-5633-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-5633-5_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-5635-9

  • Online ISBN: 978-1-4612-5633-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation