Abstract
Germ cell tumors of both gonadal and extragonadal origin may contain a variety of cells capable of secreting hormones which occasionally produce clinical manifestations. Endocrine changes may also result from an effect of the tumor on the adjacent stroma, particularly within the ovary, or from decreased secretory activity of an involved organ as a result of destruction of its parenchyma. This article will describe the types of endocrine abnormalities associated with germ cell tumors and the mechanisms involved in the production of these abnormalities.
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References
Abell MR (1968) Undifferentiated malignant germ cell neoplasm (embryonal carcinoma) of ovary with stromal luteinization. Am J Obstet Gynecol 101:570–572
Aiginger P, Kolbe H, Kuhbock J, Spona J, Geyer G (1981) The endocrinology of testicular germinal cell tumours. Acta Endocrinol 97:419–426
Aiman J, Nalick RH, Jacobs A, Porter JC, Edman CD, Vellios F, MacDonald PC (1977) The origin of androgen and estrogen in a virilized postmenopausal woman with bilateral benign cystic teratomas. Obstet Gynecol 49:695–704
Akhtar M, Young I, Brody H (1975) Anterior pituitary component in benign cystic ovarian teratomas. Am J Clin Pathol 64:14–19
Albrechtsen R, Klee JG, Moller JE (1972) Primary intracranial germ cell tumours including five cases of endodermal sinus tumour. Acta Pathol Microbiol Scand [A], Suppl, 233:32–38
Alves de Lima, Pereira de Carvallo (1978) Tumores Funcionantes do Ovario. Editora Manole Limitada, Sao Paulo, Brazil, pp 114–123
Anderson CT, Carlson IH (1975) Elevated plasma testosterone and gonadal tumors in two 46, XY “sisters”. Arch Pathol 99:360–363
Anderson T, Waldmann TA, Javadpour N, Glatstein E (1979) Testicular germcell neoplasms: recent advances in diagnosis and therapy. Ann Intern Med 90:373–385
Aparicio SR, Cowen PN, Croft CB (1972) Argentaffin carcinoma arising in a sacrococcygeal teratoma. J Pathol 107:49–53
Bartlett DJ, Grant JK, Pugh MA, Aherne W (1968) A familial feminizing syndrome. A family showing intersex characteristics with XY chromosomes in three female members. J Obstet Gynaecol Br Commonw 75:199–210
Beck JS, Fulmer HF, Lee ST (1969) Solid malignant ovarian teratoma with “embryoid bodies” and trophoblastic differentiation. J Pathol 99:67–73
Berdjis CC, Mostofi FK (1977) Carcinoid tumors of the testis. J Urol 118:777–782
Blackwell WJ, Dockerty MB, Masson JC, Mussey RD (1946) Dermoid cysts of the ovary; their clinical and pathologic significance. Am J Obstet Gynecol 51:151–172
Bosman FT, Louwerens J-WK (1981) APUD cells in teratomas. Am J Pathol 104:174–180
Brown H, Lane M (1965) Cushing’s and malignant carcinoid syndromes from ovarian neoplasm. Arch Intern Med 115:490–494
Bruton OC, Martz DC, Gerard ES (1961) Precocious puberty due to secreting chorionepithelioma (teratoma) of the brain. J Pediatr 59:719–725
Carlson HE (1980) Gynecomastia. N Engl J Med 303:795–799
Civantos F, Rywlin A (1972) Carcinomas with trophoblastic differentiation and secretion of gonadotropin. Cancer 29:789–798
Cocco AE, Conway SJ (1975) Zollinger-Ellison syndrome associated with ovarian mucinous cystadenocarcinoma. N Engl J Med 293:485–486
Danon M, Weintraub BD, Kim SH, Scully RE, Crawford JD (1978) Sexual precocity in a male due to thoracic polyembryoma. J Pediatr 92:51–54
Dayal Y, Tashjian AH, Wolfe HJ (1979) Immunocytochemical localization of calcitonin-producing cells in a strumal carcinoid with amyloid stroma. Cancer 43:1331–1338
Dikman SH, Toker C (1971) Strumal carcinoid of the ovary with masculinization. Cancer 27:925–930
Federman DD, Scully RE (1970) Case records of the Massachusetts General Hospital Case 13-1970 N Engl J Med 282:676–681
Ferenczy A, Okagaki T, Richart RM (1971) Para-endocrine hypercalcemia in ovarian neoplasms. Report of mesonephroma with hypercalcemia and review of literature. Cancer 27:427–433
Fine G, Smith RW, Pachter MR (1962) Primary extragenital choriocarcinoma in the male subject. Case report and review of literature. Am J Med 32:776–794
Fox H, Langley FA (1976) Tumours of the Ovary. Year Book Medical Publishers, Chicago, pp 236–241
Friedman NB (1951) The comparative morphogenesis of extragenital and gonadal teratoid tumors. Cancer 4:265–276
Friedman NB (1959) Choriocarcinoma of the testis and extragenital choriocarcinoma in men. Ann NY Acad Sci 80:161–176
Gaillard JA (1974) Differentiation and organization in teratomas. In: Sherbet GV (ed) Neoplasia and Cell Differentiation. S Karger, Basel, pp 319–349
Greco MA, LiVolsi VA, Pertschuk LP, Bigelow B (1979) Strumal carcinoid of the ovary. An analysis of its components. Cancer 43:1380–1388
Griffiths K, Grant JK, Browning MCK, Whyte WG, Sharp JL (1966) Steriod synthesis in vitro by tumour tissue from a dysgenetic gonad. J Endocrinol 34:155–162
Hasleton PS, Kelehan P, Whittaker JS, Burslen RW, Turner L (1978) Benign and malignant struma ovarii. Arch Pathol Lab Med 102:180–184
Javadpour JM, McIntire KR, Waldman TA (1978) Human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) in sera and tumor cells of patients with testicular seminoma. Cancer 42:2768–2772
Kim W, Bockman R, Lemos L, Lewis JL (1981) Hypercalcemia associated with epidermoid carcinoma in ovarian cystic teratoma. Obstet Gynecol 57:81–84
Kofler E, Spona J (1971) Hormone studies of an ovarian dysgerminoma. Am J Obstet Gynecol 111:1028–1033
Kubo O, Yamasaki H, Kamijo Y, Amano K, Kitamuralk, Demura R (1977) Human chorionic gonadotropin produced by ectopic pinealoma in a girl with precocious puberty. J Neurosurg 47:101–105
Kurman RJ, Norris HJ (1976a) Malignant mixed germ cell tumors of the ovary. Obstet Gynecol 48:579–589
Kurman RJ, Norris HJ (1976b) Embryonal carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis. Cancer 38:2420–2433
Kurman RJ, Scardino PT, McIntire KR, Waldman TA, Javadpour N (1977) Cellular localization or alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using an indirect immunoperoxidase technique. A new approach to classification utilizing tumor markers. Cancer 40:2136–2151
Kurohara SS, George FW, Dykhuisen RF, Leary KL (1967) Testicular tumors: analysis of 196 cases treated at the US Naval Hospital in San Diego. Cancer 20:1089–1098
LeFevre RE, Stewart BH, Levin HS, Straffon RA, Banowsky LH, Heivitt CB (1975) Testis tumors: review of 125 cases at the Cleveland Clinic. Urology 6:588–593
Leyson JFJ (1974) Mediastinal seminoma associated with exophthalmos and gynecomastia. Urology 11:366–369
Mann AS (1967) Bilateral exophthalmos in seminoma. J Clin Endocrinol Metab 27:1500–1502
Mark EJ, Hedinger C (1965) Changes in remaining tumor-free testicular tissue in cases of seminoma and teratoma. Virchows Arch Pathol Anat 340:84–92
Martini N, Golbey RB, Hajdu SI, Whitmore WF, Beattie EJ (1974) Primary mediastinal germ cell tumors. Cancer 33:763–769
Masson P (1956) Tumeurs Humaines. Libraire Maloine, Paris pp 28–29
McKechnie JC, Fechner RE (1971) Choriocarcinoma and adenocarcinoma of the esophagus with gonadotrophin secretion. Cancer 27:694–702
McKeel DW, Askin FB (1978) Ectopic hypophyseal hormonal cells in benign cystic teratoma of the ovary. Arch Pathol Lab Med 102:122–128
Meyer-Hofmann G, Schwarzkopf H, Hartmann H (1960) Spontaneous hypoglycemia with extrapancreatic tumors. Dtsch Med Wochenschr 85:2106–2108
Morley JE, Jacobsen RJ, Melamed J, Hershman JM (1976) Choriocarcinoma as a cause of thyrotoxicosis. Am J Med 60:1036–1040
Mostofi FK, Price EB (1973) Tumors of the male genital tract. In: Atlas of Tumor Pathology, 2nd series, Fascicle 8, Armed Forces Institute of Pathology, Washington, DC
Mostofi FK, Sobin LH (1977) International Histological Classification of Tumours No. 16. Histological Typing of Testis Tumours. World Health Organization, Geneva
Murayami H, Kikuchi M, Imai T (1981) Ovarian carcinoid composed of argyrophil and argentaffin cells. Am J Surg Pathol 5:77–84
Odell WD, Bates RW, Rivlin RS, Lippsett MB, Hertz R (1963) Increased thyroid function without clinical hyperthyroidism in patients with choriocarcinoma. J Clin Endocrinol 23:658–664
Park CH, Reid JD (1980) Adenocarcinoma of the colon with choriocarcinoma in its metastases. Cancer 46:570–575
Reid JD (1970) Neoplastic structure and function as expressions of genetic information systems. NZ Med J 71:303–304
Rhoden AE (1944) Precocious sexual and somatic development in male infant with presacral teratoma containing androgen-producing tissue with discussion of mechanism of precocity caused by teratomas. J Clin Endocrinol 4:185–193
Richardson GS, Scully RE (1972) Case records of the Massachusetts General Hospital Case 11-1972. N Engl J Med 286:594–600
Robboy SJ, Norris HJ, Scully RE (1975) Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases. Cancer 36:404–418
Robboy SJ, Scully RE, Norris HJ (1977) Primary trabecular carcinoid of the ovary. Obstet Gynecol 49:202–207
Robboy SJ, Scully RE (1980) Strumal carcinoid of ovary. Cancer 46:2019–2034
Scully RE (1970) Gonadoblastoma. A review of 74 cases. Cancer 25:1340–1356
Scully RE (1979) Tumors of the ovary and maldeveloped gonads. In: Atlas of Tumor Pathology, 2nd series, Fascicle 16, Armed Forces Institute of Pathology, Washington, DC
Serov SF, Scully RE, Sobin LH (1973) International Histological Classification of Tumours No. 9. Histological Typing of Ovarian Tumours. World Health Organization, Geneva
Schlumberger HG (1946) Teratoma of the anterior mediastinum in the group of military age. Arch Pathol 41:398–144
Sickles EA, Belliveau RE, Wiernik PH (1974) Primary mediastinal choriocarcinoma in the male. Cancer 33:1196–1203
Simson LR, Lampe I, Abell MR (1968) Suprasellar germinomas. Cancer 22:533–544
Skrabanek P, Kirrane J, Powell D (1979) A unifying concept of chorionic gonadotropin production in malignancy. Invest Cell Pathol 2:75–81
Steigbigel NH, Oppenheim JJ, Fishman LM, Carbone PP (1964) Metastatic embryonal carcinoma of the testis associated with elevated plasma TSH-like activity and hyperthyroidism. N Engl J Med 271:345–349
Stepanas AV, Samaan NA, Schultz BS, Holoye PY (1978) Endocrine studies in testicular tumor patients with and without gynecomastia. Cancer 41:369–376
Sternberg WH, Dhurandhar HN (1977) Functional ovarian tumors of stromal and sex cord origin. Human Pathol 8:565–582
Stewart KR, Casey MJ, Gondos B (1981) Endodermal sinus tumor of the ovary with virilization. Light and electronmicroscopic study. Am J Surg Pathol 5:385–391
Talerman A (1977) Germ cell tumors of the ovary. In: Blaustein A (ed) Pathology of the Female Genital Tract. Springer-Verlag, New York, pp 527–585
Talerman A, Gratama S, Miranda S, Okagaki T (1978) Primary carcinoid of the testis. Cancer 42:2696–2706
Taylor JB, Solomon DH, Levine RE, Ehrlich RM (1978) Exophthalmos in seminoma. Regression with steroids and orchiectomy. J Amer Med Assn 240:860–861
Thackray RC, Crane WAJ (1976) in Pugh RCB (ed) Pathology of the Testis. Blackwell Scientific Publications, Oxford pp 176–178
Ueda G, Nobuaki H, Hayakawa K, Tanizawa O, Ichii H, Nakagawa H, Mineda H, Furuyama J, Matsumoto K, Mori M (1972) Clinical histochemical and biochemical studies of an ovarian dysgerminoma with trophoblasts and Leydig cells. Am J Obstet Gynecol 114:748–754
Ueda G, Sato Y, Yamasaki M, Inoue M, Hiramatsu K, Kurachi K, Amino N, Miyai K (1978) Strumal carcinoid of the ovary. Histological, ultrastructural and immunohistological studies with anti-human thyroglobulin. Gynecol Oncol 6:411–419
Woodruff JD, Rauh JT, Markley RL (1966) Ovarian struma. Obstet Gynecol 27:194–201
Wurtman RJ, Kammer H (1966) Melatonin synthesis by an ectopic pinealoma. N Engl J Med 274:1233–1237
Young RH, Prat J, Scully RE (1982) Ovarian Sertoli-Leydig cell tumors with heterologous elements. (1) Gastrointestinal epithelium and carcinoid. A clinico-pathologic analysis of thirty-six cases. Cancer (in press)
Zaloudek CJ, Tavassoli FA, Norris HJ (1981) Dysgerminoma with synctiotrophoblastic giant cells. A histologically and clinically distinctive subtype of dysgerminoma. Am J Surg Pathol 5:361–367
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Herrington, J.B., Scully, R.E. (1983). Endocrine Aspects of Germ Cell Tumors. In: Damjanov, I., Knowles, B.B., Solter, D. (eds) The Human Teratomas. Contemporary Biomedicine, vol 3. Humana Press. https://doi.org/10.1007/978-1-4612-5628-1_9
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DOI: https://doi.org/10.1007/978-1-4612-5628-1_9
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