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The Human Teratomas pp 285–311Cite as

The Characteristics of Cell Lines Derived from Human Germ Cell Tumors

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Part of the book series: Contemporary Biomedicine ((CB,volume 3))

Abstract

Cell lines derived from human tumors enable the properties of neoplastic cells to be analyzed under more controlled conditions than are possible in a clinical setting. This approach is especially important in the case of germ cell tumors in which histological complexity obscures their origins and the relationships between the various elements of which they may be composed. Interpreting the significance of alphafetoprotein (AFP) and human chorionic gonadotropin (HCG) production in patients with germ cell tumors illustrates these problems. Often the serum levels of these markers may be affected differently after therapy, indicating that they are produced by different cell types (Braunstein et al., 1973). Also embryological data would suggest that AFP (Gitlin and Boesman, 1967; Gitlin and Perricelli, 1970) is a marker of yolk sac carcinoma, and HCG (Midgley and Pierce, 1962) is a marker of choriocarcinoma. Nevertheless, these proteins have been reported in patients in whom neither carcinoma has been recognized histologically (Javadpour et al., 1978; Javadpour, 1980). Analysis of well-defined cell lines corresponding to the different components of these tumors may help to clarify existing histological classifications, which are based largely on morphology, and to provide new criteria for more sound diagnosis and assessment of methods of treatment.

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  1. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    Peter W. Andrews

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  1. Peter W. Andrews
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  1. Department of Pathology, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, USA

    Ivan Damjanov

  2. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    Davor Solter

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Andrews, P.W. (1983). The Characteristics of Cell Lines Derived from Human Germ Cell Tumors. In: Damjanov, I., Knowles, B.B., Solter, D. (eds) The Human Teratomas. Contemporary Biomedicine, vol 3. Humana Press. https://doi.org/10.1007/978-1-4612-5628-1_13

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