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The Human Teratomas pp 267–284Cite as

Human Testicular Germ Cell Tumors In Vitro

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Part of the book series: Contemporary Biomedicine ((CB,volume 3))

Abstract

Until recently, human testicular germ cell tumors were studied primarily by examination of surgical specimens, and many ideas about their biology are predicated on data from the mouse teratocarcinoma system, which has been developed and exploited widely through in vivo and in vitro research. For example, mouse teratocarcinomas contain a mixture of adult, embryonic, and extraembryonic tissues, in the form of pluripotent embryonal carcinoma (EC) stem cells and their differentiated derivatives, that depict stages in embryogenesis (reviewed by Graham, 1977; Jacob, 1977; Solter and Damjanov, 1979; Martin, 1980). Largely on the basis of these observations, it is believed that human EC cells also differentiate and thus produce the other types of nonseminomatous tumors that comprise embryonic (teratoma) and extraembryonic (choriocarcinoma and yolk sac) tissue. Not all pathologists agree with this thinking, however, and as a result, the classification of human germ cell tumors, on which management of the disease is based, is a controversial subject, as reflected in the number of classification systems proposed (see reviews by Nochomovitz et al., 1977; Mostofi, 1977). The system proposed by the World Health Organization and used in this chapter classifies human testicular germ cell tumors as seminoma, embryonal carcinoma (EC), mature and immature teratoma, teratocarcinoma (EC with teratoma), choriocarcinoma, and yolk sac tumor (Bär and Hedinger, 1976; Nochomovitz et al., 1977).

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Author information

Authors and Affiliations

  1. Department of Urologic Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA

    David L. Bronson, Ralph V. Clayman & Elwin E. Fraley

Authors
  1. David L. Bronson
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  2. Ralph V. Clayman
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  3. Elwin E. Fraley
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Editor information

Editors and Affiliations

  1. Department of Pathology, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, USA

    Ivan Damjanov

  2. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    Davor Solter

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© 1983 The HUMANA Press Inc.

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Bronson, D.L., Clayman, R.V., Fraley, E.E. (1983). Human Testicular Germ Cell Tumors In Vitro. In: Damjanov, I., Knowles, B.B., Solter, D. (eds) The Human Teratomas. Contemporary Biomedicine, vol 3. Humana Press. https://doi.org/10.1007/978-1-4612-5628-1_12

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  • DOI: https://doi.org/10.1007/978-1-4612-5628-1_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-5630-4

  • Online ISBN: 978-1-4612-5628-1

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