Connectivity of Transplants in the Cerebellum: A Model of Developmental Differences in Neuroplasticity

  • Monica M. Oblinger
  • Gopal D. Das
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


The problem of mammalian central nervous system (CNS) regeneration has been a cynosure for neurobiologists for nearly a century. Different types of central neurons have been shown to differ in their response to direct injury. Some, namely, the weakly myelinated monoaminergic systems, maintain considerable reGenerative capacity through adulthood (reviewed in Björklund and Stenevi 1979). Others, such as the long myelinated systems of the spinal cord, exhibit nearly none. While the current consensus on the capacity of most intrinsic CNS neurons to exhibit true regeneration remains pessimistic, demonstrations of a similar response, compensatory sprouting of residual fibers in response to partial denervation, have gained general acceptance. Clearly, in many respects, these forms of a sprouting response are inherently similar since both involve the active elongation of axons.


Purkinje Cell Cerebellar Cortex Axonal Growth Cerebellar Hemisphere Immature Host 
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Copyright information

© Springer-Verlag New York Inc. 1983

Authors and Affiliations

  • Monica M. Oblinger
    • 1
  • Gopal D. Das
    • 2
  1. 1.Department of AnatomyCase Western Reserve University School of MedicineClevelandUSA
  2. 2.Department of Biological SciencesPurdue UniversityWest LafayetteUSA

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