Abstract
Review articles frequently begin with an apologia to explain why the subject merits extensive study. Why for yeast meiosis and sporulation should this be necessary? The intelligent reader will doubtless appreciate that yeast are ideal subjects for experimental study, and that there is a fascination in trying to understand at a molecular level how an organism switches from one phase of its life cycle to another. He or she will be curious as to how meiosis, that process fundamental to those with any interest in sex (and variation), takes place and how it differs from mitosis. Some would see in the processes of yeast meiosis and concommitant spore formation an example of cellular differentiation and want to understand the mechanisms that control a cell developing from one form to another. Others may view the processes in the context of their possible involvement in the evolution of eukaryotes (Cavalier-Smith 1981), or from the more practical standpoint that with the recent insight into the regulation of the related phenomenon of homothallism in yeast (Klar et al. 1981; Nasmyth et al. 1981), sporulation may provide a system for studying in detail other mechanisms of eukaryotic regulation and that these might be exploited in practical ways.
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References
Ajam, N. (1981). Regulation of sporulation in Saccharomyces cerevisiae. Ph.D. Thesis, University of Edinburgh.
Baker, B. S., Carpenter, A. T., Esposito, M. S., Esposito, R. E., Sandler, L. (1976). The genetic control of meiosis. Ann. Rev. Genet. 10:53–134.
Beckett, A., Illingworth, R. F., Rose, A. H. (1973). Ascospore wall development in Saccharomyces cerevisiae. J. Bacteriol. 113:1054–1057.
Beggs, J. D. (1978). Transformation of yeast by a replicating hybrid plasmid. Nature 275:104–109.
Betz, H. (1977). Protein degradation and sporulation in yeast. In: Cell Differentiation in Microorganisms, Plants and Animals, edited by L. Nover and K. Mothes. Amsterdam: North-Holland, pp. 243–255.
Betz, H., Weiser, U. (1976). Protein degradation and proteinases during yeast sporulation. Eur. J. Biochem. 62:65–74
Betz, H., Weiser, U. (1976). Protein degradation during yeast sporulation: enzyme and cytochrome patterns. Eur. J. Biochem. 70:385–395.
Bresch, C., Müller, G., Egel, R. (1968). Genes involved in meiosis and sporulation of a yeast. Mol. Gen. Genet. 102:301–306.
Briley, M. S., Illingworth, R. F., Rose, A. H., Fisher, D. J. (1970). Evidence for a surface protein layer on the Saccharomyces cerevisiae ascospore. J. Bacteriol. 104:588–589.
Cavalier-Smith, T. (1981). The origin and early evolution of the eukaryotic cell. In: Molecular and Cellular Aspects of Microbial Evolution, 32nd Symp. Soc. Gen. Microbiol., edited by M. J. Carlile, J. F. Collins, and B. E. B. Moseley. London: Cambridge University Press, pp. 33–84.
Colunna, N. J., Magee, P. T. (1978). Glycogenolytic enzymes in sporulating yeast. J. Bacteriol. 134:844–853.
Crandall, M., Egel, R., Mackay, V. L. (1977). Physiology of mating in three yeasts. Adv. Microbial Physiol. 15, 307–398.
Croes, A. F. (1966). Duplication of DNA during meiosis in Baker’s yeast. Exp. Cell Res. 41:452–454.
Croes, A. F. (1967). Induction of meiosis in yeast. I. Timing of cytological and biochemical events; II. Metabolic factors leading to meiosis. Planta 76:209–226, 227–237.
Curiale, M. S., Petryna, M. M., Mills, D. (1976). Ribonucleic acid synthesized in meiotic cells of Saccharomyces cerevisiae: effect of culture medium pH. J. Bacteriol. 126:661–667.
Dawes, I. W. (1975). Study of cell development using derepressed mutations. Nature 255:707–708.
Dawes, I. W. (1981). Sporulation in evolution. In: Molecular and Cellular Aspects of Microbial Evolution, edited by M. J. Carlile, J. F. Collins, and B. E. B. Moseley. London: Cambridge University Press, pp. 85–130.
Dawes, I. W., Calvert, G. R. (1981). Mutants of Saccharomyces cerevisiae defective in the initiation of sporulation. Soc. Gen. Microbiol. Quart. 8:249.
Dawes, I. W., Calvert, G. R., Martin, T. A. (1980). Initiation of meiosis and sporulation in Saccharomyces cerevisiae: regulation of protein synthesis in mutants altered in initiation. Abstracts 10th Int. Conf. Yeast Genet. Mol. Biol., Louvain-la-Neuve, p. 152.
Dawes, I. W., Hardie, I. D. (1974). Selective killing of vegetative cells in sporulated yeast cultures by exposure to diethyl ether. Mol. Gen. Genet. 131:281–289.
Dawes, I. W., Wright, J. F., Vezinhet, F., Ajam, N. (1980). Separation on Urografin gradients of subpopulations from sporulating Saccharomyces cerevisiae cultures. J. Gen. Microbiol. 119:165–171.
del-Rey, F., Santos, T., Garcia-Acha, I., Nombela, C. (1980). Synthesis of ß-glucan-ases during sporulation in Saccharomyces cerevisiae: formation of a new sporulation-specific 1,3-ß-glucanase. J. Bacteriol. 143:621–627.
Dion, P., Mandelstam, J. (1980). Germination properties as marker events characterizing later stages of Bacillus subtilis spore formation. J. Bacteriol. 141:786–792.
Durieu-Trautmann, O., Delavier-Klutchko, C. (1977). Effect of ammonia and glutamine on macromolecular synthesis and breakdown during sporulation of Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 79:438–442.
Emanuel, J. R., Magee, P. T. (1981). Timing of ribosome synthesis during ascosporogenesis of yeast cells: evidence for early function of haploid daughter genomes. J. Bacteriol. 145:1342–1350.
Engels, F., Croes, A. (1968). The synaptonemal complex in yeast. Chromosoma, Berlin 25, 104–106.
Ephrussi, B., Hottinguer, H. (1951). On an unstable cell state in yeast. Cold Spring Harbor Symp. Quant. Biol. 16, 75–86.
Esposito, M. S., Esposito, R. E. (1969). The genetic control of sporulation in Saccharomyces. I. The isolation of temperature-sensitive sporulation-deficient mutants. Genetics 61:78–89.
Esposito, M. S., Esposito, R. E. (1974a). Genes controlling meiosis and spore formation in yeast. Genetics 78:215–225.
Esposito, M. S., Esposito, R. E. (1975). Mutants of meiosis and ascospore formation. Meth. Cell Biology, 11:303–326.
Esposito, M. S., Esposito, R. E., Arnaud, M., Halvorson, H. O. (1969). Acetate utilization and macromolecular synthesis during sporulation of yeast. J. Bacteriol. 100:180–186.
Esposito, M. S., Esposito, R. E., Arnaud, M., Halvorson, H. O. (1970). Conditional mutants of meiosis in yeast. J. Bacteriol. 104:202–210.
Esposito, R. E. (1980). Sporulation. In: Yeast Genetics and Molecular Biology 1980, edited by A. Goffeau and J.-M. Wiame. Workshop Reports 10th Int. Conf., Louvain-la-Neuve, pp. 19–25.
Esposito, R. E., Esposito, M. S. (1974b). Genetic recombination and commitment to meiosis in Saccharomyces. Proc. Nat. Acad. Sci. USA 71:3172–3176.
Esposito, R. E., Frink, N., Bernstein, P., Esposito, M. S. (1972). The genetic control of sporulation in Saccharomyces. II. Dominance and complementation of mutants of meiosis and spore formation. Mol. Gen. Genet. 114:241–248.
Fast, D. (1973). Sporulation synchrony of Saccharomyces cerevisiae in various carbon sources. J. Bacteriol. 116:925–930.
Fogel, S., Roth, R. (1974). Mutations affecting meiotic gene conversion in yeast. Mol. Gen. Genet. 130:189–201.
Fowell, R. R. (1975). Ascospores of Yeasts. In: Spores VI, edited by P. Gerhardt, R. N. Costilow and H. L. Sadoff. Washington, DC: American Society for Microbiology, pp. 124–131.
Game. J. C., Cox, B. S. (1971). Allelism of mutants affecting sensitivity to radiation in yeast and a proposed nomenclature. Mutation Res. 24:328–331.
Game, J. C., Mortimer, R. K. (1974). A genetic study of X-ray sensitive mutants in yeast. Mutation Res. 24:281–292.
Game, J. C., Zamb, T. S., Braun, R., Resnick, M., Roth, R. (1980). The role of radiation (rad) genes in meiotic recombination in yeast. Genetics 94:51–68.
Gerlach, W. L. (1974). Sporulation in mating-type homozygotes of Saccharomyces cerevisiae. Heredity 32:241–249.
Grewal, N. S., Miller, J. J. (1972). Formation of asci with two diploid spores by diploid cells of Saccharomyces. Can. J. Microbiol. 18:1897–1905.
Guth, E., Hashimoto, T., Conti, S. (1972). Morphogenesis of ascospores in Saccharomyces cerevisiae. J. Bacteriol. 109:869–880.
Haber, J. E., Esposito, M. S., Magee, P. T., Esposito, R. E. (1975). Current trends in genetic and biochemical study of yeast sporulation. In: Spores VI, edited by P. Gerhardt, R. N. Costilow, and H. L. Sadoff. Washington, D.C.: Am. Soc. Microbiol., pp. 132–137.
Haber, J. E., Halvorson, H. O. (1972). Regulation of sporulation in yeast. In: Current Topics in Developmental Biology, Vol. 7, edited by A. A. Moscona and A. Munroy. New York: Academic Press, pp. 61–82.
Haber, J. E., Halvorson, H. O. (1975). Methods of sporulation and germination of yeasts. Meth. Cell Biol. 11:45–69.
Hall, B. D., Hopper, A. (1973). Control of sporulation by mating type genes in Saccharomyces cerevisiae. Colloq. Int. Cent. Rech. Sci. 227:141–144.
Hartwell, L. H. (1974). Saccharomyces cerevisiae cell cycle. Bacteriol. Rev. 38:164–198.
Hawthorne, D. C. (1976). UGA mutations and UGA suppressors in yeast. Biochimie 58:179–182.
Hawthorne, D. C. (1980). Mating in yeast (regulation of transcription). In: Yeast Genetics and Molecular Biology, 1980, Workship Reports 10th Int. Conf., Louvain-la-Meuve, edited by A. Goffeau and J. M. Wiame, pp. 55–61.
Heywood, P., Magee, P. T. (1976). Meiosis in protists: some structural and physiological aspects of meiosis in algae, fungi and protozoa. Bacteriol. Rev. 40:190–240.
Hicks, J., Strathern, J., Herskowitz, I. (1977). The cassette model of mating type interconversion. In: DNA Insertion Elements, Plasmids and Episomes, edited by A. Bukhari, J. Shapiro, and S. Adhya. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory, pp. 457–462.
Hicks, J. B., Hinnen, A. and Fink, G. R. (1979). Properties of yeast transformation. Cold Spring Harbor Symp. Quant. Biol. 43:1305–1313.
Hitchins, A. D., Slepecky, R. A. (1969). Bacterial sporulation as a modified procaryotic cell division. Nature 223:804–807.
Hopper, A. K., Magee, P. T., Welch, S. K., Friedman, M., Hall, B. D. (1974). J. Bacteriol. 119:619–628.
Hranueli, D., Piggot, P. J., Mandelstam, J. (1974). Statistical estimate of the total number of operons specific for Bacillus subtilis sporulation. J. Bacteriol. 119:684–690.
Jenkinson, H. F., Sawyer, W. D., Mandelstam, J. (1980). Synthesis and order of assembly of spore coat proteins in Bacillus subtilis. J. Gen. Microbiol. 123:1–16.
Johnston, L. H., Williamson, D. H., Johnson, A. L. (1982). An analysis of the mechanism of premeiotic DNA synthesis in the yeast Saccharomyces cerevisiae. Exp. Cell Res., in press.
Kane, S. M., Roth, R. (1974). Carbohydrate metabolism during ascospore development in yeast. J. Bacteriol. 118:8–14.
Kassir, Y., Simchen, G. (1976). Regulation of mating and meiosis in yeast by the mating-type region. Genetics 82:187–206.
Klapholtz, S., Esposito, R. E. (1980). Recombination and chromosome segregation during the single division meiosis in spol 2-1 and spol 3-1 diploids. Genetics 96:589–611.
Klar, A. J. S., Strathern, J. N., Broach, J. R., Hicks, J. B. (1981). Regulation of transcription in expressed and inexpressed mating type cassettes of yeast. Nature 289:239–244.
Kraig, E., Haber, J. E. (1980). Messenger ribonucleic acid and protein metabolism during sporulation of Saccharomyces cerevisiae. J. Bacteriol. 144:1098–1112.
Leibmann, S. W., Sherman, F., Stewart, J. (1976). Isolation and characterization of amber suppressors in yeast. Genetics 82:251–272.
Lynn, R. R., Magee, P. T. (1970). Development of the spore wall during ascospore formation in Saccharomyces cerevisiae. J. Cell Biol. 44:688–692.
Mackay, V., Manney, T. R. (1974). Mutations affecting sexual conjugation and related processes in Saccharomyces cerevisiae. I. Isolation and phenotype characterization of non-mating mutants. II. Genetic analysis of non-mating mutants. Genetics 76:255–271, 173–288.
Magee, P. T. (1975). Changes in DNA-dependent RNA polymerase in sporulating yeast. Mol. Biol. Rep. 1:275–281.
Malone, R. E., Esposito, R. E. (1981). Recombinationless meiosis in Saccharomyces cerevisiae. Mol. Cellular Biol. 1:891–901.
Matur, A., Berry, D. R. (1978). The use of step enzymes as markers during meiosis and ascospore formation in Saccharomyces cerevisiae. J. Gen Microbiol. 109:205–213.
Micio, A., Guesdon, X. (1980). Isocitratase (thre-D5-isocitrate glyoxalatelyase:EC 4.1.3.1) activity during Saccharomyces carlsbergensis sporulation. Bull. Fe. Natl. Super. Agron. Ind. Aliment. 22:23–27.
Miller, J. J. (1963). The metabolism of yeast sporulation. V. Stimulation and inhibition of sporulation and growth by nitrogenous compounds. Can. J. Microbiol. 9:259–277.
Mills, D. (1972). Effect of pH on adenine and amino acid uptake during sporulation in Saccharomyces cerevisiae. J. Bacteriol. 112, 519–526.
Mills, D. (1980). Quantitative and qualitative analysis of polyadenylated RNA sequences during meiosis of Saccharomyces cerevisiae. Abst. 10th Int. Conf. Yeast Genet. Mol. Biol., Louvain-la-Neuve, p. 55.
Miyake, S. Sando, N., Sato, S. (1971). Biochemical changes in yeast during sporulation. II. Acetate metabolism. Development, Growth & Differentiation 12:285–295.
Moens, P. B. (1971). Fine structure of ascospore development in the yeast Saccharomyces cerevisiae. Can. J. Microbiol. 17:507–510.
Moens, P. B., Esposito, R. E., Esposito, M. S. (1974). Aberrant nuclear behavior at meiosis and anucleate spore formation by sporulation-deficient (spo) mutations of Saccharomyces cerevisiae. Exp. Cell Res. 83:166–174.
Moens, P. B., Rapport, E. (1971). Spindles, spindle plaques and meiosis in the yeast Saccharomyces cerevisiae (Hansen). J. Cell Biol. 50:344–361.
Moir, A. (1981). Germination of a spore coat-defective mutant of Bacillus subtilis. J. Bacteriol. 146:1106–1116.
Mortimer, R. K., Hawthorne, D. C. (1966). Genetic mapping in Saccharomyces. Genetics 53:165–173.
Mortimer, R. K., Hawthorne, D. C. (1969). Yeast genetics. In: The Yeasts, edited by A. H. Rose and J. S. Harrison. London: Academic Press, pp. 385–460.
Mortimer, R. K., Hawthorne, D. C. (1973). Genetic mapping in Saccharomyces. IV. Mapping of temperature-sensitive genes and use of disomic strains in localizing genes. Genetics. 74:35–54.
Mortimer, R. K., Hawthorne, D. C. (1975). Genetic mapping in yeast. Meth. Cell Biol. 11:221–233.
Nasmyth, K. A., Tatchell, K. (1980). The structure of transposable yeast mating type loci. Cell 19:753–764.
Nasmyth, K. A., Tatchell, K., Hall, B. D., Astell, C., Smith, M. (1981). A position effect in the control of transcription at yeast mating type loci. Nature 289:244–250.
Peroa, J., Gancedo, C. (1980). A phosphoenolpyruvate carboxykinase mutant of Saccharomyces cerevisiae. Abst. 10th Int. Conf. Yeast Genet. Mol. Biol., Louvain-la-Neuve. p. 66.
Petersen, J. G. L., Kielland-Brandt, M. C., Nilsson-Tillgren, T. (1979). Protein patterns of yeast during sporulation. Carlsberg Res. Commun. 44:149–162.
Petersen, J. G. L., Pinon, R. (1979). In vivo labelling of proteins associated with folded chromosomes of yeast. Carlsberg Res. Commun. 44:395–402.
Piggot, P. J., Coote, J. G. (1976). Genetic aspects of bacterial endospore formation. Bacteriol. Rev. 40:908–962.
Pinon, R. (1977). Effect of ammonium ions on sporulation of Saccharomyces cerevisiae. Exp. Cell Res. 105:367–378.
Prakash, S., Prakash, L., Burke, W., Montelone, B. (1980). Effects of the RAD 52 gene on recombination in Saccharomyces cerevisiae. Genetics 94:31–50.
Pratje, E., Shulz, R., Schnierer, S., Michaelis, G. (1979). Sporulation of mitochondrial respiratory deficient mit - mutants of Saccharomyces cerevisiae. Mol. Gen. Genet. 176:411–415.
Prescott, D. M. (ed.) (1975). Methods in Cell Biology, Vol. XI. New York: Academic Press.
Put, H. M. C., Sand, F. E. M. J. (1975). Some notes on the heat resistance of ascosporogenous yeasts. J. Appl. Bacteriol. 39(3):iii.
Reid, B. J., Hartwell, L. H. (1977). Regulation of mating in the cell cycle of Saccharomyces cerevisiae. J. Cell Biol. 75:335–365.
Rine, J., Sprague, G. F., Herskowitz, I. (1981). rmel Mutation of Saccharomyces cerevisiae: map position and bypass of mating locus control of sporulation. Mol. Cellular Biol. 1:958–960.
Roth, R., Fogel, S. (1971). A system selective for yeast mutants deficient in meiotic recombination. Mol. Gen. Genet. 112:295–305.
Roth, R., Lusnak, K. (1970). DNA synthesis during yeast sporulation: genetic control of an early developmental event. Science 168:493–494.
Rothstein, R. J., Esposito, R. E., Esposito, M. S. (1976). The effect of ochre suppression on meiosis and ascospore formation in Saccharomyces. Genetics 85:35–54.
Sena, E. P., Radin, D. N., Welch, J., Fogel, S. (1975). Synchronous mating in yeasts. Meth. Cell Biol. 11:71–88.
Sherman, F., Roman, H. (1963). Evidence for two kinds of allelic recombination in yeast. Genetics 48:255–261.
Shilo, V., Simchen, G., Shilo, B. (1978). Initiation of meiosis in cell cycle initiation mutants of Saccharomyces cerevisiae. Exp. Cell Res. 112:241–248.
Simchen, G. (1974). Are mitotic functions required in mitosis? Genetics 76:745–753.
Simchen, G., Pinon, R., Salts, V. (1972). Sporulation in Saccharomyces cerevisiae: premeiotic DNA synthesis, readiness and commitment. Exp. Cell Res. 75: 207–218.
Snider, I.I., Miller, J. J. (1966). A serological comparison of vegetative cell and ascus wall and the spore coat of Saccharomyces cerevisiae. Can. J. Microbiol. 12:485–488.
Strathern, J., Hicks, J., Herskowitz, I. (1981). Control of cell type in yeast by the mating type locus. The α1-α2 hypothesis. J. Mol. Biol. 147:357–372.
Struhl, K. (1980). Expression of cloned genes in yeast (regulation of transcription). In: Workshop Reports, 10th Int. Conf. Yeast Genet. Mol. Biol. edited by A. Goffeau and J.-M. Wiame, Louvain-la-Neuve, pp. 51–54.
Tingle, M., Klar Singh, A. J., Henry, S. A., and Halvorson, H. O. (1973). Ascospore formation in yeast. In: Microbial Differentiation, 23rd Symp. Soc. Gen. Microbiol., edited by J. M. Ashworth and J. E. Smith, Cambridge: Cambridge University Press, pp. 209–243.
Trew, B. J., Friesen, J. D., Moens, P. B. (1979). Two dimensional protein patterns during growth and sporulation in Saccharomyces cerevisiae. J. Bacteriol. 138:60–69.
Vezinhet, F., Kinnaird, J. H., Dawes, I. W. (1979). The physiology of mutants derepressed for sporulation in Saccharomyces cerevisiae. J. Gen. Microbiol. 115:391–402.
Williamson, D. H., Fennel, D. J. (1975). The use of fluorescent DNA-binding agent for detecting and separating yeast mitochondrial DNA. Meth. Cell Biol. 12:335–351.
Williamson, M., Fogel, S. (1980). Correction defective (cor) mutants that alter the frequency and length of correction tracks in meiotic hybrid DNA. Abst. 10th Int. Conf. Yeast Genet. Mol. Biol., Louvain-la-Neuve, p. 44.
Wright, J. F., Dawes, I. W. (1979). Sporulation-specific protein changes in yeast. FEBS Lett. 104:183–186.
Wright, J. F., Ajam, N., Dawes, I. W. (1981). The nature and timing of sporulation-specific protein changes in Saccharomyces cerevisiae. Mol. Cellular Biol. 1:910–918.
Zakharov, I. A., Inge-Vechtomov, S. G. (1964). Ascospore isolation from yeast for genetic analysis without a micromanipulator. Issledovania po Genetike (English translation) 2:134–139.
Zakharov, I. A., Kozhina, T. N. (1967). The genetics of mating in yeast. Genetika 11:110–115.
Zubenko, G. S., Mitchell, A. P., Jones, E. W. (1979). Septum formation, cell division, and sporulation in mutants of yeast deficient in proteinase B. Proc. Natl. Acad. Sci. USA 76:2395–2399.
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Dawes, I.W. (1983). Genetic Control and Gene Expression During Meiosis and Sporulation in Saccharomyces cerevisiae . In: Spencer, J.F.T., Spencer, D.M., Smith, A.R.W. (eds) Yeast Genetics. Springer Series in Molecular Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5491-1_2
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