Yeast Genetics pp 421-437 | Cite as

Approaches to the Genetic Analysis and Breeding of Brewer’s Yeast

  • Morten C. Kielland-Brandt
  • Torsten Nilsson-Tillgren
  • Jens G. Litske Petersen
  • Steen Holmberg
  • Claes Gjermansen
Part of the Springer Series in Molecular Biology book series (SSMOL)

Abstract

Man has subjected many plants to breeding to suit his needs better. Some plant species have been bred for thousands of years. In modern times plant breeding has become increasingly intentional and systematic. Saccharomyces yeasts belong, according to their use, to man’s old, cultivated plants, but with the exception of pure culture selection (Hansen 1888) they have undergone little intentional or systematic breeding.

Keywords

Fermentation Starch Recombination Histidine Adenine 

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References

  1. Anderson, E., Martin, P. A. (1975). The sporulation and mating of brewing yeasts. J. Inst. Brew. 81:242–247.Google Scholar
  2. Barney, M. C., Jansen, G. P., Helbert, J. R. (1980a). Use of spheroplast fusion and genetic transformation to introduce dextrin utilization into Saccharomyces uvarum. Am. Soc. Brew. Chem. J. 38:1–5.Google Scholar
  3. Barney, M. C., Jansen, G. P., Helbert, J. R. (1980b). Use of genetic transformation for the introduction of flocculence into yeast. Am. Soc. Brew. Chem. J. 38:71–74.Google Scholar
  4. Beggs, J. D. (1978). Transformation of yeast by a replicating hybrid plasmid. Nature 275:104–109.PubMedCrossRefGoogle Scholar
  5. Brown, A. J. P., Goodey, A. R., Tubb, R. S. (1981). Interstrain transfer of the 2µm DNA plasmid of Saccharomyces by cytoduction. J. Inst. Brew. 87:234–238.Google Scholar
  6. Burton, K. (1956). A study of the conditions and mechanism of the diphenylamine reaction for the colorimetrie estimation of deoxyribonucleic acid. Biochem. J. 62:315–323.PubMedGoogle Scholar
  7. Cabane, B., Ramos-Jeunehomme, C., Lapage, N., Masschelein, C. A. (1974). Vicinal diketones—the problem and prospective solutions. Am. Soc. Brew. Chem. Proc. 1973:94–99.Google Scholar
  8. Cameron, J. R., Philippsen, P., Davis, R. W. (1977). Analysis of chromosomal integration and deletions of yeast plasmids. Nucl. Acids Res. 4:1429–1448.PubMedCrossRefGoogle Scholar
  9. Christensen, B. E. (1979). Somatic hybridization in Saccharomyces cerevisiae: Analysis of products of protoplast fusion. Carlsberg Res. Commun. 44:225–233.CrossRefGoogle Scholar
  10. Clayton, E., Howard, G. A., Martin, P. A. (1973). Yeast hybridization. Am. Soc. Brew. Chem. Proc. 1972: 78–81.Google Scholar
  11. Conde, J., Fink, G. R. (1976). A mutant of Saccharomyces cerevisiae defective for nuclear fusion. Proc. Natl. Acad. Sci. USA 73:3651–3655.PubMedCrossRefGoogle Scholar
  12. Conde Zurita, J., Mascort Suárez, J. L. (1981). Effect of the mitochondrial genome on the fermentation behaviour of brewing yeast. Eur. Brew. Conv. Congr., Copen-hagen, 177–186.Google Scholar
  13. Cryer, D. R., Eccleshall, R., Marmur, J. (1975). Isolation of yeast DNA. In: Methods in Cell Biology, edited by D. M. Prescott. New York: Academic Press, Vol. XII, pp. 39–44.Google Scholar
  14. Dutcher, S. K. (1981). Internuclear transfer of genetic information in karl-1/KAR1 heterokaryons in Saccharomyces cerevisiae. Mol. Cell. Biol. 1:245–253.PubMedGoogle Scholar
  15. Emeis, C. C. (1961). Polyploide Kulturhefen. Eur. Brew. Conv. Congr., Wien, 205–215.Google Scholar
  16. Emeis, C. C. (1971). A new hybrid yeast for the fermentation of wort dextrins. Am. Soc. Brew. Chem. Proc. 58–62.Google Scholar
  17. Erratt, J. A., Stewart, G. G. (1978). Genetic and biochemical studies on yeast strains able to utilize dextrins. Am. Soc. Brew. Chem. J. 36:151–161.Google Scholar
  18. Fowell, R. R. (1969). Sporulation and hybridization of yeasts. In: The Yeasts, edited by A. H. Rose, J. S. Harrison. London and New York: Academic Press, Vol. 1, pp. 303–383.Google Scholar
  19. Gjermansen, C., Sigsgaard, P. (1981). Construction of a hybrid brewing strain of Saccharomyces carlsbergensis by mating of meiotic segregants. Carlsberg Res. Commun. 46:1–11.CrossRefGoogle Scholar
  20. Goodey, A. R., Tubb, R. S. (1981). A yeast gene responsible for the production of 4-vinyl guaiacol from ferulic acid. Soc. Gen. Microbiol. Quart. 8:103 (abstr.).Google Scholar
  21. Gunge, N., Nakatomi, Y. (1972). Genetic mechanisms of rare matings of the yeast Saccharomyces cerevisiae heterozygous for mating type. Genetics 70:41–58.PubMedGoogle Scholar
  22. Gunge, N., Tamaru, A. (1978). Genetic analysis of products of protoplast fusion in Saccharomyces cerevisiae. Japan. J. Genet. 53:41–49.CrossRefGoogle Scholar
  23. Hansen, E. C. (1888). Undersogelser fra gjœringsindustriens praxis. Meddelelser fra Carlsberg Laboratoriet 2:257–322.Google Scholar
  24. Herbert, D., Phipps, P. J., Strange, R. E. (1971). Chemical analysis of microbial cells. In: Methods in Microbiology, edited by J. R. Norris, D. W. Ribbons. London and New York: Academic Press, Vol. 5B, pp. 209–344.Google Scholar
  25. Hinnen, A., Hicks, J. B., Fink, G. R. (1978). Transformation of yeast. Proc. Natl. Acad. Sci. USA 75:1929–1933.PubMedCrossRefGoogle Scholar
  26. Holmberg, S. (1982). Genetic differences between Saccharomyces carlsbergensis and S. cerevisiae. II. Restriction endonuclease analysis of genes in chromosome III. Carlsberg Res. Commun. 47:233–244.CrossRefGoogle Scholar
  27. Holmberg, S., Kielland-Brandt, M. C., Nilsson-Tillgren, T., Petersen, J. G. L. (1979a). Molecular characterization of three his4 deletion mutants in Saccharomyces cerevisiae. Carlsberg Res. Commun. 44:283–288.CrossRefGoogle Scholar
  28. Holmberg, S., Petersen, J. G. L., Nilsson-Tillgren, T., Kielland-Brandt, M. C. (1979b). Molecular characterization of a Saccharomyces plasmid containing the HIS4 gene. Carlsberg Res. Commun. 44:269–282.CrossRefGoogle Scholar
  29. Jansen, G. P., Barney, M. C., Heibert, J. R., Esposito, M. S. (1979). Nonvectoras-sociated transformation in Saccharomyces. J. Appl. Biochem. 1:369–376.Google Scholar
  30. Johnston, J. R. (1965a). Breeding yeasts for brewing, I. Isolation of breeding strains. J. Inst. Brew. 71:130–135.Google Scholar
  31. Johnston, J. R. (1965b). Breeding yeasts for brewing, II. Production of hybrid strains. J. Inst. Brew. 71:135–137.Google Scholar
  32. Kielland-Brandt, M. C. (1981). The genetics of brewer’s yeast. Eur. Brew. Conv. Congr., Copenhagen, 263–276.Google Scholar
  33. Kielland-Brandt, M. C., Nilsson-Tillgren, T., Holmberg, S., Petersen, J. G. L., Svenningsen, B. A. (1979a). Transformation of yeast without the use of foreign DNA. Carlsberg Res. Commun. 44:77–87.CrossRefGoogle Scholar
  34. Kielland-Brandt, M. C., Petersen, J. G. L., Mikkelsen, J. D. (1979b). Mutants in the biosynthesis of isoleucine in a non-mating, non-sporulating brewing strain of Saccharomyces carlsbergensis. Carlsberg Res. Commun. 44:27–36.CrossRefGoogle Scholar
  35. Kielland-Brandt, M. C., Wilken, B., Holmberg, S., Petersen, J. G. L., Nilsson-Tillgren, T. (1980). Genetic evidence for nuclear location of 2-micron DNA in yeast. Carlsberg Res. Commun. 45:119–124.CrossRefGoogle Scholar
  36. Kielland-Brandt, M. C., Gjermansen, C., Nilsson-Tillgren, T., Petersen, J. G. L., Holmberg, S., Sigsgaard, P. (1981a). Genetics of a lager production yeast. Tech. Quart. Master Brew. Assoc. Am. 18:185–187.Google Scholar
  37. Kielland-Brandt, M. C., Nilsson-Tillgren, T., Petersen, J. G. L., Holmberg, S. (1981b). Transformation in yeast without the involvement of bacterial plasmids. In: Molecular Genetics in Yeast, edited by D. von Wettstein, J. Friis, M. Kielland-Brandt, A. Stenderup. Copenhagen: Munksgaard, pp. 369–382.Google Scholar
  38. Lewis, C. W., Johnston, J. R., Martin, P. A. (1976). The genetics of yeast flocculation. J. Inst. Brew. 82:158–160.Google Scholar
  39. Livingston, D. M. (1977). Inheritance of the 2µm DNA plasmid from Saccharomyces. Genetics 86:73–84.PubMedGoogle Scholar
  40. Mortimer, R. K., Schild, D. (1980). Genetic map of Saccharomyces cerevisiae. Microbiol. Rev. 44:519–571.PubMedGoogle Scholar
  41. Nilsson-Tillgren, T., Petersen, J. G. L., Holmberg, S., Kielland-Brandt, M. C. (1979). Stabilization by chromosomal integration of HIS4 from an unstable yeast transformant. Meeting on: The Molecular Biology of Yeast. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory, abstract p. 125.Google Scholar
  42. Nilsson-Tillgren, T., Petersen, J. G. L., Holmberg, S., Kielland-Brandt, M. C. (1980). Transfer of chromosome III during kar mediated cytoduction in yeast. Carlsberg Res. Commun. 45:113–117.CrossRefGoogle Scholar
  43. Nilsson-Tillgren, T., Gjermansen, C., Kielland-Brandt, M. C., Petersen, J. G. L., Holmberg, S. (1981). Genetic differences between Saccharomyces carlsbergensis and S. cerevisiae. Analysis by single chromosome transfer. Carlsberg Res. Commun. 46:65–76.CrossRefGoogle Scholar
  44. Ramos-Jeunehomme, C., Masschelein, C. A. (1977). Controle genetique de la formation des dicetones vicinales chez Saccharomyces cerevisiae. Eur. Brew. Conv. Congr., Amsterdam, 267–283.Google Scholar
  45. Russell, I., Stewart, G. G. (1979). Spheroplast fusion of brewer’s yeast strains. J. Inst. Brew. 85:95–98.Google Scholar
  46. Russell, I., Stewart, G. G., Reader, H. P., Johnston, J. R., Martin, P. A. (1980). Revised nomenclature of genes that control yeast flocculation. J. Inst. Brew. 86:120–121.Google Scholar
  47. Scherer, S., Davis, R. W. (1979). Replacement of chromosome segments with altered DNA sequences constructed in vitro. Proc. Natl. Acad. Sci. USA 76:4951–4955.PubMedCrossRefGoogle Scholar
  48. Solingen, P. van, Plaat, J. B. van der (1977). Fusion of yeast spheroplasts. J. Bacteriol. 130:946–947.PubMedGoogle Scholar
  49. Southern, E. M. (1975). Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.PubMedCrossRefGoogle Scholar
  50. Spencer, J. F. T., Spencer, D. M. (1977a). Hybridization of non-sporulating and weakly sporulating strains of brewer’s and distiller’s yeasts. J. Inst. Brew. 83:287–289.Google Scholar
  51. Spencer, J. F. T., Spencer, D. M. (1977b). Apparent bisexual behavior of yeast strains obtained from hybridization of industrial yeasts of the genus Saccharomyces with auxotrophic diploids. Antonie van Leeuwenhoek 43:245–254.PubMedCrossRefGoogle Scholar
  52. Stewart, G. G., Russell, I. (1977). The identification, characterization and mapping of a gene for flocculation in Saccharomyces sp. Can. J. Microbiol. 23:441–447.PubMedCrossRefGoogle Scholar
  53. Stewart, G. G., Russell, I. (1979). Current use of the “new” genetics in research and development of brewer’s yeast strains. Eur. Brew. Conv. Congr., Berlin, 475–490.Google Scholar
  54. Stewart, G. G., Russell, I., Goring, T. (1975). Nature-nurture anomalies—further studies in yeast flocculation. Am. Soc. Brew. Chem. Proc. 33:137–147.Google Scholar
  55. Struhl, K., Stinchcomb, D. T., Scherer, S., Davis, R. W. (1979). High-frequency transformation of yeast: Autonomous replication of hybrid DNA molecules. Proc. Natl. Acad. Sci. USA 76:1035–1039.PubMedCrossRefGoogle Scholar
  56. Tamaki, H. (1978). Genetic studies of ability to ferment starch in Saccharomyces: Gene polymorphism. Mol. Gen. Genet. 164:205–209.CrossRefGoogle Scholar
  57. Thorne, R. S. W. (1951). The genetics of flocculence in Saccharomyees cerevisiae. Compt. Rend. Lab. Carlsberg, Sér. Physiol. 25:101–140.Google Scholar
  58. Tubb, R. S. (1979). Applying yeast genetics. A current assessment. J. Inst. Brew. 85:286–289.Google Scholar
  59. Tubb, R. S. (1980). 2/im DNA plasmid in brewery yeasts. J. Inst. Brew. 86: 78–80.Google Scholar
  60. Wettstein, D. von (1979). Biochemical and molecular genetics in the improvement of malting barley and brewer’s yeast. Eur. Brew. Conv. Congr., Berlin, 587–629.Google Scholar
  61. Winge, Ø. (1944). On segregation and mutation in yeast. Compt. Rend. Lab. Carlsberg, Sér. Physiol. 24:79–96.Google Scholar
  62. Winge, Ø., Laustsen, O. (1938). Artificial species hybridization in yeast. Compt. Rend. Lab. Carlsberg, Sér. Physiol. 22:235–247.Google Scholar
  63. Winge, Ø., Laustsen, O. (1939). On 14 new yeast types, produced by hybridization. Compt. Rend. Lab. Carlsberg, Sér. Physiol. 22:337–355.Google Scholar
  64. Wright, R. E., Lederberg, J. (1957). Extranuclear transmission in yeast heterokaryons. Proc. Natl. Acad. Sci. USA 43:919–923.PubMedCrossRefGoogle Scholar
  65. Young, T. W. (1981). The genetic manipulation of killer character into brewing yeast. J. Inst. Brew. 87:292–295.Google Scholar
  66. Zakharov, I. A., Yarovoy, B. Ph. (1977). Cytoduction as a new tool in studying the cytoplasmic heredity in yeast. Mol. Cell. Biochem. 14:15–18.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1983

Authors and Affiliations

  • Morten C. Kielland-Brandt
    • 1
  • Torsten Nilsson-Tillgren
    • 2
  • Jens G. Litske Petersen
    • 1
  • Steen Holmberg
    • 1
  • Claes Gjermansen
    • 1
  1. 1.Department of PhysiologyCarlsberg LaboratoryCopenhagen ValbyDenmark
  2. 2.Institute of GeneticsUniversity of CopenhagenCopenhagen KDenmark

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