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Vasospasm

  • Chapter
Intracranial Aneurysms

Abstract

The term vasospasm is used in this chapter to denote an abnormal, inappropriate, or unnatural constriction of blood vessels. This pathologic constriction is usually described clinically as involving part of an artery (segmental constriction) or part of a circulatory bed, being of long duration, and which is or may be deleterious to the tissue involved (172). It is not known whether this prolonged contraction is due to factors which only stimulate contractile activity or which inhibit the relaxation of the vessel, or both. In contrast, physiologic vasoconstriction is commonly considered to be diffuse and even in character and to serve the special needs of organs (as in autoregulation). The term also has been applied hypothetically to explain the causes of specific neurologic diseases, such as migraine (42), long before there were any observations to substantiate the hypotheses and was used to explain postmortem evidence of brain ischemia associated with ruptured aneurysms (175).

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Bibliography

  1. Abdel-Halim MS, Hamberg M, Sjoquist B, et al.: Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain. Prostaglandins 14: 633–643, 1977

    PubMed  CAS  Google Scholar 

  2. Adams CBT, Chir M, Fearnside MR, et al.: An investigation with serial angiography into the evolution of cerebral arterial spasm following aneurysm. J Neurosurg 49: 805–815, 1978

    PubMed  CAS  Google Scholar 

  3. Adler H: Untersuchungen zur Pathogenese des zerebralen Vasospasmus. Neurochirurgia (Stuttgart) 17: 202–208, 1974

    CAS  Google Scholar 

  4. Alksne JF: Myonecrosis in chronic experimental vasospasm. Surgery 76: 1–7, 1974

    PubMed  CAS  Google Scholar 

  5. Alksne JF, Greenhoot JH: Experimental catecholamine-induced chronic cerebral vasospasm. Myonecrosis in vessel wall. J Neurosurg 41: 440–445, 1974

    PubMed  CAS  Google Scholar 

  6. Allcock JM: Arterial spasm in subarachnoid haemorrhage. A clinical and experimental study. Acta Radiol 5: 73–83, 1966

    CAS  Google Scholar 

  7. Allcock JM, Drake CG: Ruptured intracranial aneurysms. The role of arterial spasm. J Neurosurg 22: 21–29, 1965

    PubMed  CAS  Google Scholar 

  8. Allen GS: Cerebral arterial spasm. Part 8. The treatment of delayed cerebral arterial spasm in human beings. Surg Neurol 6: 71–80, 1976

    PubMed  CAS  Google Scholar 

  9. Allen GS: Cerebral arterial spasm. A discussion of present and future research. Neurosurgery 1: 142–148, 1977

    PubMed  CAS  Google Scholar 

  10. Allen GS, Bahr AL: Cerebral arterial spasm. Part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine. Neurosurgery 4: 43–47, 1979

    PubMed  CAS  Google Scholar 

  11. Allen GS, Banghart SB: Cerebral arterial spasm. Part 9. In vitro effects of nifedipine on serotonin-, phenylephrine-, and potassium-induced contractions of canine basilar and femoral arteries. Neurosurgery 4:37–42, 1979

    PubMed  CAS  Google Scholar 

  12. Allen GS, Gold LHA, Chou SN, et al.: Cerebral arterial spasm. Part 3. In vivo intracisternal production of spasm by serotonin and blood and its reversal by phenoxybenzamine. J Neurosurg 40:451–458, 1974

    Google Scholar 

  13. Allen GS, Gross CJ: Cerebral arterial spasm. Part 7. In vitro effects of alpha-adrenergic agents on canine arteries from six anatomical sites and six blocking agents on serotonin-induced contractions of the canine basilar artery. Surg Neurol 6:63–70, 1976

    PubMed  CAS  Google Scholar 

  14. Allen GS, Gross CJ, French LA, et al.: Cerebral arterial spasm. Part 5. In vitro contractile activity of vasoactive agents including human CSF on human basilar and anterior cerebral arteries. J Neurosurg 44:594–600, 1976

    CAS  Google Scholar 

  15. Allen GS, Gross CJ, Henderson LM, et al.: Cerebral arterial spasm. Part 4. In vitro effects of temperature, serotonin analogues, large nonphysiological concentrations of serotonin, and extracellular calcium and magnesium on serotonin-induced contractions of the canine basilar artery. J Neurosurg 44:585–593, 1976

    CAS  Google Scholar 

  16. Allen, GS, Henderson LM, Chou SN, et al.: Cerebral arterial spasm. Part 1. In vitro contractile activity of vasoactive agents on canine basilar and middle cerebral arteries. J Neurosurg 40:433–441, 1974

    CAS  Google Scholar 

  17. Allen GS, Henderson, LM, Chou SN: Cerebral arterial spasm. Part 2. In vitro contractile activity of serotonin in human serum and CSF on the canine basilar artery and its blockage by methysergide and phenoxybenzamine. J Neurosurg 40:442–450, 1974

    CAS  Google Scholar 

  18. Altura BT, Altura BM: Withdrawal of magnesium causes vasospasm while elevated magnesium produces relaxation of tone in cerebral arteries. Neuroscience Letters 20: 323–327, 1980

    PubMed  CAS  Google Scholar 

  19. Altura BT, Altura BM: Magnesium deficiency induces cerebral arterial spasm. Stroke 12: 118, 1981

    Google Scholar 

  20. Arseni C, Nash F: Cerebral ischemia in the course of ruptured aneurysms. Europ Neurol 1: 308–323, 1968

    PubMed  CAS  Google Scholar 

  21. Arutiunov Al, Baron MA, Majorova NA: Experimental and clinical study of the development of spasm of the cerebral arteries related to subarachnoid hemorrhage. J Neurosurg 32: 617–625, 1970

    Google Scholar 

  22. Arutiunov Al, Baron MA, Majorova NA: The role of mechanical factors in the pathogenesis of short-term and prolonged spasm of the cerebral arteries. J Neurosurg 40: 459–472, 1974

    Google Scholar 

  23. Asano T, Tanishima T, Sasaki T, et al.: Possible participation of free radical reactions initiated by clotlysis in the pathogenesis of vasospasm after subarachnoid hemorrhage. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams & Wilkins, 1980, pp. 190–201

    Google Scholar 

  24. Astrup J, Henser D, Lassen NA, et al.: Evidence against H+ and K+ as main factors for the control of cerebral blood flow: a microelectrode study. In: Cerebral Vascular Smooth Muscle and Its Control. Ciba Foundation Symposium 56. Amsterdam, Elsevier /Excerpta Medica, 1979, pp. 313–332

    Google Scholar 

  25. Bagley C Jr: Blood in cerebrospinal fluid. Reultant functional and organic alterations in central nervous system: experimental data. Arch Surg 17: 18–81, 1928

    Google Scholar 

  26. Bell WH III, Sundt TM Jr, Nofzinger JD: The response of cortical vessels to serotonin in experimental cerebral infarction. J Neurosurg 26: 203–212, 1967

    PubMed  Google Scholar 

  27. Bergvall U, Steiner L, Forster DMC: Early pattern of cerebral circulatory disturbances following subarachnoid haemorrhage. Neuroradiology 5: 24–32, 1973

    PubMed  CAS  Google Scholar 

  28. Bevan JA, Duckies SP, Lee TJ-F: Histamine potentiation of nerve- and drug-induced responses of rabbit cerebral artery. Circ Res 36: 647–653, 1975

    PubMed  CAS  Google Scholar 

  29. Blumenkopf B, Wilkins RH, Feldman JM: Cerebral vasospasm and neurological deficit after aneurysm rupture despite administration of reserpine and kanamycin. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 518–524

    Google Scholar 

  30. Bohr DF, Goulet PL, Taquini AC Jr: Direct tension recording from smooth muscle of resistance vessels from various organs. Angiology 12: 478–485, 1961

    PubMed  CAS  Google Scholar 

  31. Boisvert D, Weir BKA, Overton T, et al.: Effect of subarachnoid injection of blood, serotonin and mock spinal fluid in monkeys. Stroke 8: 10–11, 1977

    Google Scholar 

  32. Boisvert DPJ, Weir BKA, Overton TR, et al.: Cerebrovascular responses to subarachnoid blood and serotonin in the monkey. J Neurosurg 50: 441–448, 1979

    PubMed  CAS  Google Scholar 

  33. Bottecchia D, Fantin G, Nassuato P, et al.: The clot as a smooth muscle. In de Gaetano G, Garattini S (eds.): Platelets: A Multidisciplinary Approach. New York, Raven Press, 1978, pp. 111–129

    Google Scholar 

  34. Boullin DJ: Cerebral Vasospasm. New York, Wiley, 1980

    Google Scholar 

  35. Boullin DJ, Bunting S, Blaso WP, et al.: Responses of human and baboon arteries to prostaglandin endoperoxides and biologically generated and synthetic prostacyclin. Their relevance to arterial spasm in man. Br J Clin Pharmacol 7: 139–147, 1979

    PubMed  CAS  Google Scholar 

  36. Boullin DJ, Du Boulay GH, Roger AT: Aetiology of cerebral arterial spasm following subarachnoid haemorrhage. Evidence against a major involvement of 5-hydroxy-tryptamine in the production of acute spasm. Br J Pharmacol 6: 203–215, 1978

    CAS  Google Scholar 

  37. Boullin DJ, Mohan J, Grahame-Smith DG: Evidence for the presence of a vasoactive substance (possibly involved in the aetiology of cerebral arterial spasm) in cerebrospinal fluid from patients with subarachnoid haemorrhage. J Neurol Neurosurg Psychiat 39: 756–766, 1976

    PubMed  CAS  Google Scholar 

  38. Brading AF: Maintenance of ionic composition. Br Med Bull 35: 227–233, 1979

    PubMed  CAS  Google Scholar 

  39. Bradley PB, Samuels GMR, Shaw JE: Correlation of prostaglandin release from the cerebral cortex of cats with the electrocorticogram, following stimulation of the reticular formation. Br J Pharmacol 37: 151–157, 1969

    PubMed  CAS  Google Scholar 

  40. Brandt L: Aspects on Cerebral Vasospasm. A Clinical and Experimental Study. Thesis. University of Lund, Sweden, 1981

    Google Scholar 

  41. Brandt L, Ljunggren B, Andersson K-E, et al.: Vasoconstrictive effects of human post-hemorrhagic cerebrospinal fluid on cat pial arterioles in situ. J Neurosurg 54: 351–356, 1981

    PubMed  CAS  Google Scholar 

  42. Brawley BW, Strandness DE Jr, Kelly WA: The biphasic response of cerebral vasospasm in experimental subarachnoid hemorrhage. J Neurosurg 28: 1–8, 1968

    PubMed  CAS  Google Scholar 

  43. Brunton TL: Observations on functional diseases of the arteries. Lancet 2: 161–164, 1915

    Google Scholar 

  44. Buckell M: Demonstration of substances capable of contracting smooth muscle in the haematoma fluid from certain cases of ruptured cerebral aneurysm. J Neurol Neurosurg Psychiat 27: 198–199, 1964

    PubMed  CAS  Google Scholar 

  45. Byrom FB: The pathogenesis of hypertensive encephalopathy and its relation to malignant phase of hypertension. Experimental evidence from hypertensive rat. Lancet 2: 201–211, 1954

    Google Scholar 

  46. Cameron IR, Segal MB: The effect on pialarteriole diameter of local changes in potassium concentration. Europ Neurol 6: 100–106, 1971–1972

    Google Scholar 

  47. Chapleau CE, White RP: Effects of prostacyclin on the canine isolated basilar artery. Prostaglandins 17: 573–580, 1979

    PubMed  CAS  Google Scholar 

  48. Chapleau CE, White RP, Robertson JT: Effects of prostaglandin synthetase inhibitors (PSI) on contractions induced by arachidonate, prostaglandin F2a and serotonin in basilar arteries. Fed Proc 38: 359, 1979

    Google Scholar 

  49. Chapleau CE, White RP, Robertson JT: Cerebral vasodilation and prostacyclin. The effects of aspirin and meclofenamate in vitro. J Neurosurg 53: 188–192, 1980

    PubMed  CAS  Google Scholar 

  50. Chapleau CE, White RP, Robertson JT: Cerebral vasospasm: effects of prostaglandin synthetase inhibitors in vitro. Neurosurgery 6: 155–159, 1980

    PubMed  CAS  Google Scholar 

  51. Chokyu M: An experimental study of cerebral vasospasm, especially on spasmogenic factors in red blood cells. Osaka City Med J 24: 211–221, 1975

    CAS  Google Scholar 

  52. Chow RWB, Newton TH, Smith MC, et al.: Cerebral vasospasm induced by subarachnoid blood and serotonin. An angiography study. Invest Radiol 3: 402–407, 1968

    PubMed  CAS  Google Scholar 

  53. Cohen RJ, Allen GS: Effects of subarachnoid blood and spasmodic agents on cerebral vasculature. In Wood JH (ed.): Neurobiology of Cerebrospinal Fluid, Vol. 1. New York, Plenum Press, 1980, pp. 287–301

    Google Scholar 

  54. Connolly RC: Cerebral ischemia in spontaneous subarachnoid haemorrhage. Ann Roy Coll Surg Engl 30: 102–116, 1962

    CAS  Google Scholar 

  55. Corkill G, Sivalingam S, Reitan JA, et al.: Dose dependency of the post-insult protective ef feet of pentobarbital in the canine experimental stroke model. Stroke 9: 10–12, 1978

    PubMed  CAS  Google Scholar 

  56. Crompton MR: Cerebral infarction following the rupture of cerebral berry aneurysms. Brain 87: 263–279, 1964

    Google Scholar 

  57. Davson H: Physiology of the Cerebrospinal Fluid. London, Churchill, 1970

    Google Scholar 

  58. Denton IC Jr, Robertson JT, Dugdale M: An assessment of early platelet activity in experimental subarachnoid hemorrhage and middle cerebral artery thrombosis in the cat. Stroke 2: 268–272, 1971

    PubMed  CAS  Google Scholar 

  59. Denton IC Jr, White RP, Robertson JT: The effects of prostaglandin Ei, Ai and F2a on the cerebral circulation of dogs and monkeys. J Neurosurg 36: 34–42, 1972

    PubMed  CAS  Google Scholar 

  60. Drake CG: Cerebral aneurysm surgery—an update. In Scheinberg P (ed.): Cerebrovascular Diseases. Tenth Princeton Conference. New York, Raven Press, 1976, pp. 289–310

    Google Scholar 

  61. du Boulay G: Distribution of spasm in the intracranial arteries after subarachnoid haemorrhage. Acta Radiol Diagn 1: 257–266, 1963

    Google Scholar 

  62. Duckies SP, Bevan RD, Bevan JA: An in vitro study of prolonged vasospasm of a rabbit cerebral artery. Stroke 7: 174–178, 1976

    Google Scholar 

  63. Duckies SP, Kim J, Bevan RD, et al.: Alteration of innervation and reactivity of monkey cerebral arteries after subarachnoid hemorrhage. Stroke 8: 10, 1977

    Google Scholar 

  64. Echlin FA: Vasospasm and focal cerebral ischemia. An experimental study. Arch Neurol Psychiat 47: 77–96, 1942

    Google Scholar 

  65. Echlin FA: Spasm of basilar and vertebral arteries caused by experimental subarachnoid hemorrhage. J Neurosurg 23: 1–11, 1965

    PubMed  CAS  Google Scholar 

  66. Echlin FA: Current concepts in the etiology and treatment of vasospasm. Clin Neurosurg 15: 133–160, 1968

    PubMed  CAS  Google Scholar 

  67. Echlin FA: Experimental vasospasm, acute and chronic, due to blood in the subarachnoid space. J Neurosurg 35: 646–656, 1971

    PubMed  CAS  Google Scholar 

  68. Ecker A, Riemenschneider PA: Artériographie demonstration of spasm of the intracranial arteries with special reference to saccular arterial aneurysms. J Neurosurg 8: 660–667, 1951

    PubMed  CAS  Google Scholar 

  69. Edvinsson L, MacKenzie ET: Amine mechanisms in the cerebral circulation. Pharmacol Rev 28: 275–353, 1977

    Google Scholar 

  70. Edvinsson L, Owman CH: Pharmacological characteristics of adrenergic alpha and beta receptors mediating vasomotor responses in vitro. Circ Res 35: 835–849, 1974

    PubMed  CAS  Google Scholar 

  71. Edvinsson L, Owman CH: A pharmacologic comparison of histamine receptors in isolated extracranial and intracranial arteries in vitro. Neurology 25: 271–276, 1975

    PubMed  CAS  Google Scholar 

  72. El-Ackad TM, Brody MJ: Evidence of non- mast cell histamine in the vascular wall. Blood Vessels 12: 181–191, 1975

    PubMed  CAS  Google Scholar 

  73. Ellis EF, Nies AS, Oates JA: Cerebral arterial smooth muscle contraction by thromboxane A2. Stroke 8: 480–486, 1977

    PubMed  CAS  Google Scholar 

  74. Ellis EF, Wei EP, Kontos HA: Vasodilation of cat cerebral arterioles by prostaglandins D2, E2, G2 and I2. Am J Physiol 237: H381–H385, 1979

    PubMed  CAS  Google Scholar 

  75. Emerson TE, Radawski D, Veenendaal M, et al.: Effects of cerebral ventricular, systemic, and local administration of prostaglandin F2a on canine cerebral hemodynamics. Prostaglandins 8: 523–530, 1974

    Google Scholar 

  76. Endo S, Suzuki J: Experimental cerebral vasospasm after subarachnoid hemorrhage. Development and degree of vasospasm. Stroke 8: 702–707, 1977

    PubMed  CAS  Google Scholar 

  77. Fein JM, Flor WJ, Cohan SL, et al.: Sequential changes of vascular ultrastructure in experimental cerebral vasospasm. Myonecrosis of subarachnoid arteries. J Neurosurg 41: 49–58, 1974

    PubMed  CAS  Google Scholar 

  78. Fisher CM, Kistler JP, Davis JM: Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 6: 1–8, 1980

    PubMed  CAS  Google Scholar 

  79. Fisher CM, Roberson GH, Ojemann RG: Cerebral vasospasm after ruptured aneurysm. Stroke 8: 11, 1977

    Google Scholar 

  80. Fisher CM, Roberson GH, Ojemann RG: Cerebral vasospasm with ruptured saccular aneurysm—the clinical manifestations. Neurosurgery 1: 245–248, 1977

    PubMed  CAS  Google Scholar 

  81. Fleischer AS, Raggio JF, Tindall GT: Aminophylline and isoproterenol in the treatment of cerebral vasospasm. Surg Neurol 8: 117–121, 1977

    PubMed  CAS  Google Scholar 

  82. Fletcher TM, Taveras JM, Pool JL: Cerebral vasospasm in angiography for intracranial aneurysms. Incidence and significance in one hundred consecutive angiograms. Arch Neurol 1: 38–47, 1959

    PubMed  CAS  Google Scholar 

  83. Flower RJ, Blackwell GL: The importance of phospholipase A2 in prostaglandin biosynthesis. Biochem Pharmacol 25: 285–291, 1976

    PubMed  CAS  Google Scholar 

  84. Forster C, Mohan J, Whalley ET: Interaction of fibrin degradation products and 5-hydroxytryptamine on various vascular smooth muscle preparations: possible role in cerebral vasospasm. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 186–189

    Google Scholar 

  85. Fox JL: Intracranial vasospasm: a study with iron compounds. Surg Neurol 11: 363–368, 1979

    PubMed  CAS  Google Scholar 

  86. Fox JL: Iron compounds and cerebral vaso spasm. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 181–183

    Google Scholar 

  87. Fox JL, Ko JP: Cerebral vasospasm: a clinical observation. Surg Neurol 10: 269–275, 1978

    PubMed  CAS  Google Scholar 

  88. Fox JL, Yasargil MG: The relief of intracranial vasospasm: an experimental study with methylprednisolone and Cortisol. Surg Neurol 3: 214–218, 1975

    PubMed  CAS  Google Scholar 

  89. Freer R, Chang J, Greenbaum LM: Studies on leukokinins. III. Pharmacological activities of leukokinins M and PMN. Biochem Pharmacol 21: 3107–3110, 1972

    PubMed  CAS  Google Scholar 

  90. Gaudet RJ, Levine L: Transient cerebral ischemia and brain cyclooxygenase products: relevance to migraine. Prostagland Ther 6: 1–2, 1980

    Google Scholar 

  91. Gelmers HJ, Beks JWF, Journee HL: Regional cerebral blood flow in patients with subarachnoid haemorrhage. Acta Neurochir 47: 245–251, 1979

    CAS  Google Scholar 

  92. Giannotta SL, Kindt GW: Total morbidity and mortality rates of patients with surgically treated intracranial aneurysms. Neurosurgery 4: 125–128, 1979

    PubMed  CAS  Google Scholar 

  93. Gilbert JC, Goldberg LI: Characterization by cyproheptadine of the dopamine-induced contraction of isolated arteries. J Pharmacol Exp Ther 193: 435–442, 1975

    PubMed  CAS  Google Scholar 

  94. Hagen AA, Gerber JN, Sweeley CC, et al.: Levels and disappearance of prostaglandin F2a in cerebral spinal fluid: A clinical and experimental study. Stroke 8: 672–675, 1977

    PubMed  CAS  Google Scholar 

  95. Hagen AA, Gerber JN, Sweeley CC, et al.: Pleocy tosis and elevation of prostaglandins F2a and E2 in cerebrospinal fluid following intracisternal injection of thrombin. Stroke 8: 236–238, 1977

    PubMed  CAS  Google Scholar 

  96. Hagen AA, White RP, Robertson JT: Synthesis of prostaglandins and thromboxane B2 by cerebral arteries. Stroke 10: 306–309, 1979

    PubMed  CAS  Google Scholar 

  97. Hamer J, Krastel A: Cerebral vasospasm after brain injury. Neurochirurgia 19: 185–189, 1976

    PubMed  CAS  Google Scholar 

  98. Handa H, Osaka K, Okamoto S: Breakdown products of erythrocytes as a cause of cerebral vasospasm. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 158–165

    Google Scholar 

  99. Handa J, Yoneda S, Koyama T, et al.: Experimental cerebral vasospasm in cats: modification by a new synthetic vasodilator YC-93. Surg Neurol 3: 195–199, 1975

    PubMed  CAS  Google Scholar 

  100. Handa J, Yoneda S, Matsuda M, et al.: Effects of prostaglandins Ai, Ei, E2 and F2a on the basilar artery of cats. Surg Neurol 2: 251–255, 1974

    PubMed  CAS  Google Scholar 

  101. Harper AM, MacKenzie ET: Effects of 5-hydroxytryptamine on pial arteriolar calibre in anesthetized cats. J Physiol 271: 735–746, 1977

    PubMed  CAS  Google Scholar 

  102. Hashi K, Matsuoku Y, Tanaka K, et al.: Treatment of cerebral vasospasm with large doses of hydrocortisone. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 611–618

    Google Scholar 

  103. Hayakawa T, Waltz AG: Experimental subarachnoid hemorrhage from a middle cerebral artery. Stroke 8: 421–426, 1977

    PubMed  CAS  Google Scholar 

  104. Hayakawa T, Waltz AG: Influence of head position on the prognosis of experimental subarachnoid hemorrhage. Arch Neurol 35: 206–212, 1978

    PubMed  CAS  Google Scholar 

  105. Heros RC, Zervas NT, Negoro M: Cerebral vasospasm. Surg Neurol 5: 354–362, 1976

    PubMed  CAS  Google Scholar 

  106. Herrmann E, Pia HW: Der cerebrale Arteriospasmus. Kasuistischer und radiologischer Beitrag zur Frage nach der Existenz von Spasmen der Hirnarterien und ihrer Bedeutung für die Genese des ischämischen Insults. Dtsche Z Nervenheilk 185: 381–392, 1963

    CAS  Google Scholar 

  107. Ho PPK, Walters P, Sullivan HR: Biosynthesis of thromboxane B2. Assay, isolation, and properties of the enzyme system in human platelets. Prostaglandins 12: 951–970, 1976

    PubMed  CAS  Google Scholar 

  108. Holmes SW: The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release. Br J Pharmacol 38: 653–658, 1970

    PubMed  CAS  Google Scholar 

  109. Hughes JT, Schianchi PM: Cerebral artery spasm. A histological study at necropsy of the blood vessels in cases of subarachnoid hemorrhage. J Neurosurg 48: 515–525, 1978

    PubMed  CAS  Google Scholar 

  110. Hunt TM, du Boulay GH, Blaso WP, et al.: Relationship between presence of vasoconstrictor activity in cerebrospinal fluid and the time after subarachnoid hemorrhage from rupture of cerebral arterial aneurysms. J Neurol Neurosurg Psychiat 42: 625–634, 1979

    PubMed  CAS  Google Scholar 

  111. Ishii R: Regional cerebral blood flow in patients with ruptured intracranial aneurysms. J Neurosurg 50: 587–594, 1979

    PubMed  CAS  Google Scholar 

  112. Ishii S, Chigasaki H, Nonaka T, et al.: Clinical usefulness of haptoglobin in the treatment of vasospasm following SAH. Neurosurgery 1: 65–66, 1977

    Google Scholar 

  113. Ishii S, Ito M, Miyaoka M, et al.: The causative factors of vasospasm and its treatment. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 556–571

    Google Scholar 

  114. Jacob HS: Granulocyte-complement interaction. A beneficial antimicrobial mechanism that can cause disease. Arch Intern Med 138: 461–463, 1978

    PubMed  CAS  Google Scholar 

  115. Jarman DA, du Boulay GH, Kendall B, et al.: Responses of baboon cerebral and extracerebral arteries to prostacyclin and prostaglandin endoperoxide in vitro and in vivo. J Neurol Neurosurg Psychiat 42: 677–686, 1979

    PubMed  CAS  Google Scholar 

  116. Johnson RJ, Potter JM, Reid RG: Arterial spasm in subarachnoid haemorrhage: mechanical considerations. J Neurol Neurosurg Psychiat 21: 68, 1958

    Google Scholar 

  117. Jonsson HT Jr, Daniell HB: Altered levels of PGF in cat spinal cord tissue following traumatic injury. Prostaglandins 11: 51–61, 1976

    PubMed  CAS  Google Scholar 

  118. Kagstrom E, Greitz T, Hanson J, et al.: Changes in cerebral blood flow after subarachnoid hemorrhage. In: Proceedings of the Third International Congress of Neurological Surgery, 1965. International Congress Series No. 110. Amsterdam, Excerpta Medica, 1966, pp. 629–633

    Google Scholar 

  119. Kapp J. Mahaley MS Jr, Odom GL: Cerebral arterial spasm. Part 1. Evaluation of experimental variables affecting the diameter of the exposed basilar artery. J Neurosurg 29: 331–356, 1968

    PubMed  CAS  Google Scholar 

  120. Kapp, J, Mahaley MS Jr, Odom GL: Cerebral arterial spasm. Part 2. Experimental evaluation of mechanical and humoral factors in pathogenesis. J Neurosurg 29: 339–349, 1968

    PubMed  CAS  Google Scholar 

  121. Kapp J, Mahaley MS Jr, Odom GL: Cerebral spasm. Part 3. Partial purification and characterization of a spasmogenic substance in feline platelets. J Neurosurg 29: 350–355, 1968

    PubMed  CAS  Google Scholar 

  122. Kapp JP, Robertson JT, White RP: Spasmogenic qualities of prostaglandin F2a in the cat J Neurosurg 44: 173–175, 1976

    CAS  Google Scholar 

  123. Karlsberg P, Elliott HW, Adams JE: Effect of various pharmacological agents on cerebral arteries. Neurology 13: 772–778, 1963

    PubMed  CAS  Google Scholar 

  124. Kelly PJ, Gorten RJ, Grossman RG, et al.: Cerebral perfusion, vascular spasm, and outcome in patients with ruptured intracranial aneurysms. J Neurosurg 7: 44–49, 1977

    Google Scholar 

  125. Kindt GW, Hudson JS, Gosh HH, et al.: Relief of arterial spasm associated with cerebral aneurysms. Europ Neurol 8: 38–42, 1972

    PubMed  CAS  Google Scholar 

  126. Kline RL, Sak DP, Haddy FJ, et al.: Pressure-dependent factors in edema formation in canine forelimbs. J Pharmacol Exp Ther 193: 452–459, 1975

    PubMed  CAS  Google Scholar 

  127. Kosnik EJ, Hunt WE: Postoperative hypertension in the management of patients with intra-cranial aneurysms. J Neurosurg 45: 148–154, 1976

    PubMed  CAS  Google Scholar 

  128. Kuschinsky W, Wahl M: In vivo evaluation of histamine receptors at pial arteries. In Ingvar DH, Lassen NA (eds.): Cerebral Function, Metabolism and Circulation. New York, Churchill Livingston, 1977, pp. 382–383

    Google Scholar 

  129. Kuwayama A, Zervas NT, Belson R, et al.: A model for experimental cerebral arterial spasm. Stroke 3: 49–56, 1972

    PubMed  CAS  Google Scholar 

  130. Kwak R, Niizuma H, Ohi T, et al.: Angiographic study of cerebral vasospasm following rupture of intracranial aneurysms. Part 1. Time of the appearance. Surg Neurol 11: 257–262, 1979

    PubMed  CAS  Google Scholar 

  131. Landau B, Ransohoff J: Prolonged cerebral vasospasm in experimental subarachnoid hemorrhage. Neurology 18: 1056–1065, 1968

    PubMed  CAS  Google Scholar 

  132. Laurent JP: Subarachnoid hemorrhage. In Wood JH (ed.): Neurobiology of Cerebrospinal Fluid, Vol. 1. New York, Plenum Press, 1980, pp. 279–286

    Google Scholar 

  133. Lee TJ-F, Che S, Bevan J A: Neurogenic sympathetic vasoconstriction of rabbit basilar artery. Circ Res 39: 120–126, 1976

    PubMed  CAS  Google Scholar 

  134. Linder M, Alksne JF: Prevention of persistent cerebral smooth muscle contraction in response to whole blood. Stroke 9: 472–477, 1978

    PubMed  CAS  Google Scholar 

  135. Lough J: Endothelial injury induced by thrombin or thrombi. Lab Invest 33: 130–135, 1975

    PubMed  CAS  Google Scholar 

  136. Lougheed WM, Tom M: A method for introducing blood into the subarachnoid space in the region of the circle of Willis in dogs. Canad J Surg 4: 329–337, 1961

    PubMed  CAS  Google Scholar 

  137. Mahaley MS Jr, Kapp J: The effect of Isordil and Cyclospasmol on vascular spasm induced in the basilar artery of the cat. Stroke 1: 325–329, 1970

    PubMed  CAS  Google Scholar 

  138. Martins AN, Doyle TF, Wright S: Effect of topically applied serotonin on local cerebral blood flow. Stroke 9: 25–28, 1978

    PubMed  CAS  Google Scholar 

  139. Martins AN, Wiley JK: Cerebral vasospasm. A review. Military Med 141: 482–485, 1974

    CAS  Google Scholar 

  140. Mayberg MR, Houser OW, Sundt TM Jr: Ultrastructural changes in feline arterial endothelium following subarachnoid hemorrhage. J Neurosurg 48: 49–57, 1978

    PubMed  CAS  Google Scholar 

  141. Mchedlishvili G, Ormotsadze L: Responses of the internal carotid artery to different endogenous vasoconstrictor substances. Blood Vessels 16: 126–134, 1979

    PubMed  CAS  Google Scholar 

  142. Mclhany MP, Cheung ST, Ozaki N, et al.: In vitro studies of a red cell spasmogenic factor. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 184–185

    Google Scholar 

  143. McQueen JD, Jeanes LD: Influence of hypothermia on intracranial hypertension. J Neurosurg 19: 277–288, 1962

    Google Scholar 

  144. Miller CA: Biochemistry of vascular smooth muscle: contractile mechanism of human basilar artery. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 68–75

    Google Scholar 

  145. Miyaoka M, Nonaka T, Watanabe H, et al.: Etiology and treatment of prolonged vasospasm. Experimental and clinical studies. Neurol Med Chir (Tokyo) 16 (Part II): 103–114, 1976

    CAS  Google Scholar 

  146. Mizukami M, Kawase T, Tazawa T, et al.: Hypothesis and clinical evidence for mechanism of chronic cerebral vasospasm after subar achnoid hemorrhage. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp Wilkins, 1980, pp. 97–106

    Google Scholar 

  147. Moncada S, Vane JR: Arachidonic acid metabolites and the interactions between platelets and blood vessel walls. N Engl J Med 300: 1142–1147, 1979

    PubMed  CAS  Google Scholar 

  148. Moretti RL, Abraham S: Stimulation of microsomal prostaglandin synthesis by a vasoactive material isolated from blood plasma. Prostaglandins 15: 603–622, 1978

    PubMed  CAS  Google Scholar 

  149. Morgan H, White RP, Pennink M, et al.: Prostaglandins and experimental cerebral vasospasm. Surg Forum 23: 447–448, 1972

    PubMed  CAS  Google Scholar 

  150. Morgan H, White RP, Pennink M, et al.: Prostaglandin activity in canine experimental cerebral vasospasm: an angiographic study. In Smith RR, Robertson JT (eds.): Subarachnoid Hemorrhage and Cerebrovascular Spasm. Springfield, Illinois, Charles C Thomas, 1975, pp. 55–62

    Google Scholar 

  151. Nagai H, Suzuki Y, Sugiura M, et al.: Experimental cerebral vasopasm. 1. Factors contributory to early spasm. J Neurosurg 41: 285–292, 1974

    PubMed  CAS  Google Scholar 

  152. Nibbelink DW: Cooperative aneurysm study: antihypertensive and antifibrinolytic therapy following subarachnoid hemorrhage from ruptured intracranial aneurysm. In Whisnant JP, Sandok BA (eds.): Cerebral Vascular Disease. New York, Grune amp; Stratton, 1975, pp. 155–165

    Google Scholar 

  153. Nibbelink DW, Torner JC, Henderson WG: Intracranial aneurysms and subarachnoid hemorrhage. A cooperative study. Antifibrinolytic therapy in recent onset subarachnoid hemorrhage. Stroke 6: 622–629, 1975

    PubMed  CAS  Google Scholar 

  154. Nielsen KC, Owman C: Contractile response and amine receptor mechanisms in isolated middle cerebral artery of the cat. Brain Res 27: 33–42, 1971

    PubMed  CAS  Google Scholar 

  155. Niizuma H, Kwak R, Otabe K, et al.: Angiographic study of cerebral vasospasm following rupture of intracranial aneurysms. II. Relation between the site of aneurysm and the occurrence of the vasospasm. Surg Neurol 11: 263–267, 1979

    PubMed  CAS  Google Scholar 

  156. Obsbahr AJ, Gladner JA, Laki K: Studies on the physiological activity of the peptide release during fibrinogen-fibrin conversion. Biochem Biophys Acta 86: 535–542, 1964

    Google Scholar 

  157. Ohta T, Kajikawa H, Funatsu N, et al.: Cerebral vasospasm and its relaxation responses to vasodilators: pathological study of severe prolonged vasospasm. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 132–138

    Google Scholar 

  158. Osaka K: Prolonged vasospasm produced by the breakdown products of erythrocytes. J Neurosurg 47: 403–411, 1977

    PubMed  CAS  Google Scholar 

  159. Osaka K, Handa H, Okamoto S: Subarachnoid erythrocytes and their contribution to cerebral vasospasm. In Wood JH (ed.): Neurobiology of Cerebrospinal Fluid, Vol. 1. New York, Plenum Press, 1980, pp. 313–323

    Google Scholar 

  160. Owman CH, Edwinsson L, Olin T, et al.: Pathophysiology of cerebral vasospasm: transmitter changes in perivascular sympathetic nerves and increased pial artery sensitivity to norepinephrine and serotonin. In Price TR, Nelson E (eds.): Cerebrovascular Diseases. New York, Raven Press, 1979, pp. 295–305

    Google Scholar 

  161. Ozaki N, Mullan S: Possible role of the erythrocyte in causing prolonged cerebral vasospasm. J Neurosurg 51: 773–778, 1979

    PubMed  CAS  Google Scholar 

  162. Peerless SJ, Kassell NF, Komatsu K, et al.: Cerebral vasospasm: acute proliferative vasculopathy? II. Morphology. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 88–96

    Google Scholar 

  163. Pelofsky S, Jacobson ED, Fisher RG: Effects of prostaglandins Ei on experimental cerebral vasospasm. J Neurosurg 36: 634–639, 1972

    PubMed  CAS  Google Scholar 

  164. Pennink M, White RP, Crockarell JR, et al.: Role of prostaglandin F2tt in the genesis of experimental cerebral vasospasm. Angiographic study in dogs. J Neurosurg 37: 398–406, 1972

    PubMed  CAS  Google Scholar 

  165. Peters ND, Di Chiro G: A model for spasm of the anterior cerebral artery. Stroke 7: 243–247, 1976

    PubMed  CAS  Google Scholar 

  166. Peterson EW, Leblanc R, Lebel F: Cyclic adenosine monophosphate antagonism of prostaglandin induced vasospasm. Surg Neurol 4: 490–496, 1975

    PubMed  CAS  Google Scholar 

  167. Peterson EW, Leblanc R, Searle R, et al.: Some considerations on cerebral vasospasm. Am Heart J 89: 124–126, 1975

    PubMed  CAS  Google Scholar 

  168. Peterson EW, Searle R, Mandy FF, et al.: The reversal of experimental vasospasm by dibutyryl–3′,5′-adenosine monophosphate. J Neurosurg 39: 730–734, 1973

    PubMed  CAS  Google Scholar 

  169. Pickard JD, Vinall PE, Simeone FA: Prostaglandins and cerebral vasospasm. A problem of interpretation. Surg Forum 26: 496–498, 1975

    PubMed  CAS  Google Scholar 

  170. Pohl J, Bruhn HD, Christophers E: Thrombin and fibrin-induced growth of fibroblasts. Role in wound repair and thrombin organization. Klin Wochenschr 57: 273–277, 1979

    PubMed  CAS  Google Scholar 

  171. Politoff A, Marci F: Pharmacologic differences between isolated perfused arteries of the choroid plexus and the brain parenchyma. Int J Neuropharmacol 5: 155–162, 1966

    PubMed  CAS  Google Scholar 

  172. Pomerantz KA, Sintetos A, Ramwell P: The effect of prostacyclin on the human umbilical artery. Prostaglandins 15: 1034–1044, 1978

    Google Scholar 

  173. Pool JL, Jacobson S, Fletcher TA: Cerebral vasospasm clinical and experimental evidence. JAMA 167: 1599–1601, 1958

    CAS  Google Scholar 

  174. Potter JM: Cerebral arterial spasm. A short review. Wld Neurol 2: 576–588, 1961

    CAS  Google Scholar 

  175. Raynor RB, McMurtry JG: Prevention of serotonin-produced cerebral vasospasm. An evaluation of blocking agents. J Neurosurg 20: 94–96, 1963

    PubMed  CAS  Google Scholar 

  176. Raynor RB, McMurtry JG, Pool JL: Cerebrovascular effects of topically applied serotonin in the cat. Neurology 11: 190–195, 1961

    PubMed  CAS  Google Scholar 

  177. Robertson EG: Cerebral lesions due to intra-cranial aneurysms. Brain 72: 150–185, 1949

    PubMed  CAS  Google Scholar 

  178. Rosenblum WI: Cerebral arteriolar spasm inhibited by ß-adrenergic blocking agents. Arch Neurol 21: 296–302, 1969

    PubMed  CAS  Google Scholar 

  179. Rosenblum WI: Constriction of pial arterioles produced by prostaglandin F2a. Stroke 6: 293–297, 1975

    PubMed  CAS  Google Scholar 

  180. Rosenblum WI: Effects of prostaglandins on cerebral blood vessels. Interaction with vasoactive amines. Neurology (Minneap) 25: 1169–1171, 1975

    CAS  Google Scholar 

  181. Rosenblum WI: Contractile responses of pial arterioles in gerbils with unilateral carotid ligation. Stroke 12: 83–85, 1981

    PubMed  CAS  Google Scholar 

  182. Rothberg C, Weir B, Overton T, et al.: Responses to experimental subarachnoid hemorrhage in the spontaneously breathing primate. J Neurosurg 52: 302–308, 1980

    PubMed  CAS  Google Scholar 

  183. Saito I, Ueda Y, Sano K: Significance of vasospasm in the treatment of ruptured intracranial aneurysms. J Neurosurg 47: 412–429, 1977

    PubMed  CAS  Google Scholar 

  184. Sano K, Saito I: Indication and timing of surgery for ruptured intracranial aneurysms with vasospasm. Neurosurgery 1: 65, 1977

    Google Scholar 

  185. Sasaki T, Wakai S, Asano T, et al.: The effect of a lipid hydroperoxide of arachidonic acid on the canine basilar artery. An experimental study on cerebral vasospasm. J Neurosurg 54: 357–365, 1981

    PubMed  CAS  Google Scholar 

  186. Shimizu K, Ohta T, Toda N: Evidence for greater susceptibility of isolated dog cerebral arteries to Ca antagonists than peripheral arteries. Stroke 11: 261–266, 1980

    PubMed  CAS  Google Scholar 

  187. Silverberg GD, Ross G, Corbin SD, et al.: Time course of serotonin-induced vasoconstriction. Neurosurgery 4: 539–542, 1979

    PubMed  CAS  Google Scholar 

  188. Simeone FA, Ryan KG, Cotter JR: Prolonged experimental cerebral vasospasm. J Neurosurg 29: 357–366, 1968

    PubMed  CAS  Google Scholar 

  189. Simeone FA, Trepper PJ, Brown DJ: Cerebral blood flow evaluation of prolonged experimental vasospasm. J Neurosurg 37: 302–311, 1972

    PubMed  CAS  Google Scholar 

  190. Simeone FA, Vinall P: Mechanisms of contractile response of cerebral artery to externally applied fresh blood. J Neurosurg 43: 37–47, 1975

    PubMed  CAS  Google Scholar 

  191. Simeone FA, Vinall PE, Pickard JD: Response of extraparenchymal cerebral arteries to biochemical environment of cerebrospinal fluid. In Wood JH (ed.): Neurobiology of Cerebrospinal Fluid, Vol. 1. New York, Plenum Press, 1980, pp. 303–311

    Google Scholar 

  192. Smith RR, Robertson JT (eds.): Subarachnoid Hemorrhage and Cerebrovascular Spasm. Springfield, Illinois, Charles C Thomas, 1975

    Google Scholar 

  193. Sonobe M, Suzuki J: Vasospasmogenic substance produced following subarachnoid haemorrhage, and its fate. Acta Neurochir 44: 97–106, 1978

    CAS  Google Scholar 

  194. Sundt TM Jr. Mangement of ischemic complications after subarachnoid hemorrhage. J Neurosurg 43: 418–425, 1975

    PubMed  Google Scholar 

  195. Sundt TM Jr, Onofrio BM, Merideth J: Treatment of cerebral vasospasm from subarachnoid hemorrhage with isoproterenol and lidocaine hydrochloride. J Neurosurg 38: 557–560, 1973

    PubMed  Google Scholar 

  196. Sundt TM Jr, Szurszewski J, Sharbrough FW: Physiological considerations important for the management of vasospasm. Surg Neurol 7: 259–267, 1977

    PubMed  Google Scholar 

  197. Suzuki S, Ishii M, Ottomo M, et al.: Changes in the subarachnoid space after experimental subarachnoid haemorrhage in the dog: scanning electron microscopic observation. Acta Neurochir 39: 1–14, 1977

    CAS  Google Scholar 

  198. Suzuki S, White RP, Chapleau CE, et al.: An experimental evaluation of anaerobic condition in the pathogenesis of cerebral vasospasm associated with subarachnoid hemorrhage. A preliminary report. Hirosaki Med J 32: 48–56, 1980

    Google Scholar 

  199. Suzuki J, Yoshimoto T, Hori S: Continuous ventricular drainage to lessen surgical risk in ruptured intracranial aneurysm. Stroke 6: 339, 1975

    Google Scholar 

  200. Svendgaard NA, Edvinsson L, Owman C, et al.: Increased sensitivity of the basilar artery to norepinephrine and 5-hydroxytryptamine following experimental subarachnoid hemorrhage. Surg Neurol 8: 191–195, 1977

    PubMed  CAS  Google Scholar 

  201. Tanabe Y, Sakata K, Yamada H, et al.: Cerebral vasospasm and ultrastructural changes in cerebral arterial wall. J Neurosurg 49: 229–238, 1978

    PubMed  CAS  Google Scholar 

  202. Tani E, Yamagata S: In vitro assay of contrac–tile activities of spastic canine basilar artery and its surrounding blood clot. J Neurosurg 51: 155–163, 1979

    PubMed  CAS  Google Scholar 

  203. Tani E, Yamagata S, Ito Y: Intercellular granules and vesicles in prolonged cerebral vasospasm. J Neurosurg 48: 179–189, 1978

    PubMed  CAS  Google Scholar 

  204. Tanishima T: Cerebral vasospasm: contractile activity of hemoglobin in isolated canine basilar arteries. J Neurosurg 53: 787–793, 1980

    PubMed  CAS  Google Scholar 

  205. Toda N: Responsiveness to potassium and calcium ions of isolated cerebral arteries. Am J Physiol 227: 1206–1211, 1974

    PubMed  CAS  Google Scholar 

  206. Toda N: The action of vasodilating drugs on isolated basilar, coronary and mesenteric arteries of the dog. J Pharmacol Exp Ther 191: 139–146, 1974

    PubMed  CAS  Google Scholar 

  207. Toda N: Analysis of the effect of 5-hydroxykynurenamine, a serotonin metabolite, on isolated cerebral arteries, aortas and atria. J Pharmacol Exp Ther 193: 385–392, 1975

    PubMed  CAS  Google Scholar 

  208. Toda N: Nicotine-induced relaxation in isolated canine cerebral arteries. J Pharmacol Exp Ther 193: 376–384, 1975

    PubMed  CAS  Google Scholar 

  209. Toda N: Influence of dopamine and norepinephrine on isolated cerebral canine arteries of the dog. Br J Pharmacol 58: 121–126, 1976

    PubMed  CAS  Google Scholar 

  210. Toda N: Actions of bradykinin on isolated cerebral and peripheral arteries. Am J Physiol 232: H267–H274, 1977

    PubMed  CAS  Google Scholar 

  211. Toda N: Acetylcholine-induced relaxation in isolated dog cerebral arteries. J Pharmacol Exp Ther 209: 352–358, 1979

    PubMed  CAS  Google Scholar 

  212. Toda N: Responses to prostaglandin H2 and I2 of isolated dog cerebral and peripheral arteries. Am J Physiol 238: H111–H117, 1980

    PubMed  CAS  Google Scholar 

  213. Toda N, Fujita Y: Responsiveness of isolated cerebral and peripheral arteries to serotonin, norepinephrine, and transmural electrical stimulation. Circ Res 33: 98–104, 1973

    PubMed  CAS  Google Scholar 

  214. Toda N, Miyazaki M: Responses of isolated dog cerebral and peripheral arteries to prostaglandins after application of aspirin and polyphoretin phosphate. Stroke 9: 490–498, 1978

    PubMed  CAS  Google Scholar 

  215. Toda N, Ozaki T, Ohta T: Cerebrovascular sensitivity to vasoconstricting agents induced by subarachnoid hemorrhage and vasospasm in dogs. J Neurosurg 46: 296–303, 1977

    PubMed  CAS  Google Scholar 

  216. Toda N, Shimizu K, Ohta T: Mechanism of cerebral arterial contraction induced by blood constituents. J Neurosurg 53: 312–322, 1980

    PubMed  CAS  Google Scholar 

  217. Urquilla PR: Prolonged contraction of isolated human and canine cerebral arteries induced by uridine 5′-triphosphate. Stroke 9: 133–136, 1978

    PubMed  CAS  Google Scholar 

  218. Urquilla PR, Marco EJ, Balfagon G: Adrenergic mechanisms in cerebral blood vessels. Effects of tyramine on the isolated middle cerebral arteries of the goat. Stroke 5: 447–452, 1974

    PubMed  CAS  Google Scholar 

  219. Urquilla PR, Marco EJ, Lluch S: Pharmacological receptors of the cerebral arteries of the goat. Blood Vessels 12: 53–67, 1975

    PubMed  CAS  Google Scholar 

  220. Van Breemen C, Aaronson P, Loutzenhiser, et al.: Ca2+ movements in smooth muscle. Chest 78: 157S–165S, 1980

    Google Scholar 

  221. Van Breemen C, Siegel B, Kalinski L, et al.: The Ca++ cycle of arterial smooth muscle. In Wilkins RH (ed.): Cerebral Arterial Vasospasm. Baltimore, Williams & Wilkins, 1980, pp. 61–67

    Google Scholar 

  222. Van Dellen JR, Buchanan N: Prolonged induced hypertension in the management of incipient cerebral infarction. Surg Neurol 8: 185–186, 1977

    PubMed  Google Scholar 

  223. Van der Werf AJM: Clinical aspects of subarachnoid hemorrhage and significance of vasospasm. Psychiat Neurol Nuerochir 75: 411–415, 1972

    Google Scholar 

  224. Vapalahti M, Hyyppa MT, Nieminen V, et al.: Brain monoamine metabolites and tryptophan in ventricular CSF of patients with spasm after aneurysm surgery. J Neurosurg 48: 58–63, 1978

    PubMed  CAS  Google Scholar 

  225. Waltz AG, Sundt TM: The microvasculature and microcirculation of the cerebral cortex after arterial occlusion. Brain 90: 681–696, 1967

    PubMed  CAS  Google Scholar 

  226. Ward A Jr: Atropine in the treatment of closed head injury. J Neurosurg 7: 398–402, 1950

    PubMed  Google Scholar 

  227. Watts C: Reserpine and cerebral vasospasm. Stroke 8: 112–114, 1977

    PubMed  CAS  Google Scholar 

  228. Wei EP, Kontos HA, Dietrich WD, et al.: Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arterial abnormalities from concussive brain injury in cats. Circ Res 48: 95–103, 1981

    PubMed  CAS  Google Scholar 

  229. Wei EP, Kontos HA, Patterson JL: Vasoconstrictor effect of angiotensin on pial arteries. Stroke 9: 487–489, 1978

    PubMed  CAS  Google Scholar 

  230. Weir B, Erasmo R, Miller J, et al.: Vasospasm in response to repeated subarachnoid hemorrhages in the monkey. J Neurosurg 33: 395–406, 1970

    PubMed  CAS  Google Scholar 

  231. Weir B, Grace M, Hansen J, et al.: Time course of vasospasm in man. J Neurosurg 48: 173–178, 1978

    PubMed  CAS  Google Scholar 

  232. Weir B, Okwuasaba FK, Cook DA, et al.: Pharmacology of vasospasm effects of various agents including blood on isolated cerebral arteries. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 237–243

    Google Scholar 

  233. Weir B, Petruk K: Pathophysiologic correlates of vasospasm in subarachnoid hemorrhage. In Smith RR, Robertson JT (eds.): Subarachnoid Hemorrhage and Cerebrovascular Spasm. Springfield, 111., Thomas, 1975, pp. 92–97

    Google Scholar 

  234. Welch KMA, Knowles L, Spira P: Local effect of prostaglandins on cat pial arteries. Europ J Pharmacol 25: 155–158, 1974

    CAS  Google Scholar 

  235. Wellum GR, Irvine TW Jr, Zervas NT: Dose responses of cerebral arteries of the dog, rabbit, and man to human hemoglobin in vitro. J Neurosurg 53: 486–490, 1980

    PubMed  CAS  Google Scholar 

  236. Wellum GR, Zervas NT, Irvine TW Jr: Effect of oxyhemoglobin on the contractility of in vitro arterial smooth muscle. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams & Wilkins, 1980, pp. 173–189

    Google Scholar 

  237. White RP: Multiplex origins of cerebral vasospasm. In Price TR, Nelson E (eds.): Cerebrovascular Diseases. New York, Raven Press

    Google Scholar 

  238. pp. 307–319

    Google Scholar 

  239. White RP: Experimental treatment of cerebral vasospasm with saline and phenoxybenzamine. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 566–577

    Google Scholar 

  240. White RP: Multiplex origins of vasoconstriction. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 50–56

    Google Scholar 

  241. White RP: Overview of the pharmacology of vasospasm. In Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980, pp. 229–236

    Google Scholar 

  242. White RP: Prostaglandins, cerebral ischemia and vasoconstriction. In Glen TM, Greenberg S (eds.): The Clinical Significance of Prostanoids in Cardiovascular and Cardiopulmonary Diseases. New York, Academic Press, 1982

    Google Scholar 

  243. White RP, Chapleau CE, Dugdale M, et al.: Cerebral arterial contractions induced by human and bovine thrombin. Stroke 11: 363–368, 1980

    PubMed  CAS  Google Scholar 

  244. White RP, Cunningham MP, Robertson JT: Inhibitory effects of hirudin and nimodipine on arterial contractions induced by thrombin. Fed Proc 40: 410, 1981

    Google Scholar 

  245. White RP, Hagen AA, Morgan H, et al.: Experimental study on the genesis of cerebral vasospasm. Stroke 6: 52–57, 1975

    PubMed  CAS  Google Scholar 

  246. White RP, Hagen AA, Bobertson JT: Experimental evaluation of the spasmogenicity of dopamine on the basilar artery. J Neurosurg 44: 45–49, 1976

    PubMed  CAS  Google Scholar 

  247. White RP, Hagen AA, Robertson JT: Effect of nonsteroid anti-inflammatory drugs on subarachnoid hemorrhage in dogs. J Neurosurg 51: 164–171, 1979

    PubMed  CAS  Google Scholar 

  248. White RP, Hagen AA, Robertson JT: Prostaglandins in cerebrospinal fluid: possible role in cerebrovascular and neurological disease. In Wood JH (ed.): Neurobiology of Cerebrospinal Fluid, Vol. 2. New York, Plenum Press, 1982

    Google Scholar 

  249. White RP, Heaton JA, Denton IC: Pharmacological comparison of prostaglandin F2a, serotonin and norepinephrine on cerebrovascular tone of monkey. Europ J Pharmacol 15: 300–309, 1971

    CAS  Google Scholar 

  250. White RP, Huang SP, Hägen AA, et al.: Experimental assessment of phenoxybenzamine in cerebral vasospasm. J Neurosurg 50: 158–163, 1979

    PubMed  CAS  Google Scholar 

  251. White RP, Morgan H, Robertson JT: Cerebrovascular effects of prostaglandins and possible role in vasospasm. In Smith RR, Robertson JT (eds.): Subarachnoid Hemorrhage and Cerebrovascular Spasm. Springfield, Illinois, Charles C Thomas, 1975, pp. 72–88

    Google Scholar 

  252. Wilkins RH: The role of intracranial arterial spasm in the timing of operations for aneurysm. Clin Neurosurg 24: 185–207, 1977

    PubMed  CAS  Google Scholar 

  253. Wilkins RH: Attempted prevention or treatment of intracranial arterial spasm. A survey. Neurosurgery 6: 198–210, 1980

    PubMed  CAS  Google Scholar 

  254. Wilkins RH (ed.): Cerebral Arterial Spasm. Baltimore, Williams amp; Wilkins, 1980

    Google Scholar 

  255. Wilkins RH, Alexander JA, Odom GL: Intra-cranial arterial spasm. A clinical analysis. J Neurosurg 29: 121–134, 1968

    PubMed  CAS  Google Scholar 

  256. Wilkins RH, Levitt P: Intracranial arterial spasm in the dog. A chronic experimental model. J Neurosurg 33: 260–269, 1970

    PubMed  CAS  Google Scholar 

  257. Wilkins RH, Levitt P: Potassium and the pathogenesis of cerebral arterial spasm in dog and man. J Neurosurg 35: 45–50, 1971

    PubMed  CAS  Google Scholar 

  258. Wilkins RH, Odom GL: Intracranial arterial spasm associated with craniocerebral trauma. J Neurosurg 32: 626–633, 1970

    PubMed  CAS  Google Scholar 

  259. Wilkins RH, Silver D, Odom GL: The role of circulating substances in intracranial arterial spasm. I. Serotonin and histamine. Neurology 16: 482–490, 1966

    PubMed  CAS  Google Scholar 

  260. Wilkins RH, Wilkins GK, Gunnells JC, et al.: Experimental studies of intracranial arterial spasm using aortic strip assays. J Neurosurg 27: 490–500, 1967

    PubMed  CAS  Google Scholar 

  261. Wilson T, Feild JR: The production of intracranial vascular spasm by hypothalamic extract. J Neurosurg 40: 473–479, 1974

    PubMed  CAS  Google Scholar 

  262. Wolfe LS, Pappius HM, Marion J: The biosynthesis of prostaglandins by brain tissue in vitro. In Samuelsson B (ed.): Advances in Prostaglandin and Thromboxane Research, Vol. 1. New York, Raven Press, 1976, pp. 345–355

    Google Scholar 

  263. Yamamoto YL, Feindel W, Wolfe LS, et al.: Experimental vasoconstriction of cerebral arteries by prostaglandins. J Neurosurg 37: 385–396, 1972

    PubMed  CAS  Google Scholar 

  264. Yashon D, Brown RJ, Hunt WE: Vasoactive properties of prostaglandin compounds on the in vitro human basilar artery. Surg Neurol 8: 111–115, 1977

    PubMed  CAS  Google Scholar 

  265. Yoshida Y: Experimental studies on fibroinolytic activity and angiospasm following subarachnoid hemorrhage in dogs. Arch Jpn Chir 47: 537–562, 1978

    CAS  Google Scholar 

  266. Yoshioka J: Morphological study of experimental cerebral vasospasm. I. Electron micro scopic examination of experimental cerebral vasospasm. Acta Med Okayama 34: 91–107, 1980

    PubMed  CAS  Google Scholar 

  267. Zervas NT, Candia M, Candia G, et al.: Reduced incidence of cerebral ischemia following rupture of intracranial aneurysms. Surg Neurol 11: 339–344, 1979

    PubMed  CAS  Google Scholar 

  268. Zervas NT, Hori H, Rosoff CB: Experimental inhibition of serotonin by antibiotic prevention of cerebral vasospasm. J Neurosurg 41:59– 62, 1974

    Google Scholar 

  269. Zervas NT, Kuwayama A, Rosoff CB, et al.: Cerebral arterial spasm. Modification by inhibition of platelet function. Arch Neurol 28: 400–404, 1973

    PubMed  CAS  Google Scholar 

  270. Zervas NT, Lavyne MH, Negoro M: Neurotransmitters and the normal and ischemic cerebral circulation. N. Engl J Med 293: 812–816, 1975

    PubMed  CAS  Google Scholar 

  271. Zurier RB: Prostaglandin release from human polymorphonuclear leukocytes. In Samuelsson B, Paoletti R (eds.): Advances in Prostaglandin and Thromboxane Research, Vol. 2. New York, Raven Press, 1976, pp. 815–818

    Google Scholar 

Additional Source Material

  • Alksne JF, Branson PJ: Prevention of experimental subarachnoid hemorrhage-induced intracranial arterial vasonecrosis with phospholiesterase inhibitor phtalazinol (EG-626). Stroke 10: 638–644, 1979

    PubMed  CAS  Google Scholar 

  • Allègre G, de Rougemont J, Thierry A: Spasme arté rial de la carotide interne dû à un anevrysme rompu du système vertébro-basilaire (àpropos de 2 cas). Neuro-Chirurgie (Paris) 9: 74–79, 1963

    Google Scholar 

  • Armstrong FS, Hayes GJ: Segmental cerebral arterial constriction associated with phenochromocytoma. Report of a case with arteriograms. J Neurosurg 18: 843–846, 1961

    PubMed  CAS  Google Scholar 

  • Arutyunova AS, Konovalov AN: Some data of morphological investigation in aneurysms of the arteries of the base of the brain. Vop Neirokhir 29: 15–19, 1965

    Google Scholar 

  • Benedict CR, Loach AB: Clinical significance of plasma adrenaline and noradrenaline concentrations in patients with subarachnoid hemorrhage. J Neurol Neurosurg Psychiat 41: 113–117, 1978

    PubMed  CAS  Google Scholar 

  • Berne RM, Rubio R, Curnish RR: Release of adenosine from ischemic brain. Effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides. Circ Res 35: 262–271, 1974

    CAS  Google Scholar 

  • Bevan JA, Bevan RD: Localized neurogenic vasoconstriction of the basilar artery. Stroke 4: 760–763, 1973

    PubMed  CAS  Google Scholar 

  • Blaumanis OR, Gertz SO, Grady PA, et al.: Thrombosis in acute experimental cerebral vasospasm. Stroke 7: 9–10, 1976

    Google Scholar 

  • Boisvert DP, Overton TR, Weir B: Cerebral arterial responses to induced hypertension following subarachnoid hemorrhage in the monkey. J Neurosurg 49: 75–83, 1978

    PubMed  CAS  Google Scholar 

  • Botterell EH, Lougheed WM, Scott JW, et al.: Hypothermia, and interruption of carotid, or carotid and vertebral circulation, in the surgical management of intracranial aneurysms. J Neurosurg 13: 1–42, 1956

    PubMed  CAS  Google Scholar 

  • Corday E, Rothenberg SF, Irving DW: Cerebral angiospasm. A cause of the cerebral stroke. Am J Cardiol 11: 66–71, 1963

    PubMed  CAS  Google Scholar 

  • Cummins BH, Griffith HB: Intracarotid phenoxybenzamine or cerebral arterial spasm. Br Med J 1: 382–383, 1971

    PubMed  CAS  Google Scholar 

  • Dickmann GH, Zamboni O, Driollet Laspiur R, et al.: Aneurysms and vasospasm: Clinicoradiological correlation. In Fusek I, Kunc Z (eds.): Proceedings of the Fourth European Congress of Neurosurgery. Present Limits of Neurosurgery. Prague, Avicenum, Czechoslovak Medical Press, 1972, pp. 229–232

    Google Scholar 

  • Falconer MA: Surgical pathology of spontaneous intracranial haemorrhage due to aneurysm and arteriovenous malformations. Proc Roy Soc Med 47: 693–700, 1954

    PubMed  CAS  Google Scholar 

  • Farrar JK Jr: Chronic cerebral arterial spasm. The role of intracranial pressure. J Neurosurg 43: 408–417, 1975

    PubMed  Google Scholar 

  • Fein JM, Boulos R: Local cerebral blood flow in experimental middle cerebral artery vasospasm. J Neurosurg 39: 337–347, 1973

    PubMed  CAS  Google Scholar 

  • Ferris EJ, Athanasoulis CA, Shapiro JH, et al.: Pharmacological aspects of intracerebral spasm secondary to cerebral hemorrhage. Experimental observations. Radiology 95: 561–566, 1970

    PubMed  CAS  Google Scholar 

  • Flamm ES, Viau AT, Ransohoff J, et al: Experimental alterations in cyclic adenosine monophosphate concentrations in the cat basilar artery. Neurology 26: 664–666, 1976

    PubMed  CAS  Google Scholar 

  • Flamm ES, Yasargil MG, Ransohoff J: Control of cerebral vasospasm by parenteral phenoxybenzamine. Stroke 3: 421–426, 1972

    PubMed  CAS  Google Scholar 

  • Fog M: Cerebral circulation. I. Reaction of pial arteries to epinephrin by direct application and intravenous injection. Arch Neurol Psychiat 41: 109–111, 1939

    CAS  Google Scholar 

  • Fox JL, Yasargil MG: The experimental effect of direct electrical current on intracranial arteries and the blood-brain barrier. J Neurosurg 41: 582–589, 1974

    PubMed  CAS  Google Scholar 

  • Fraser RAR, Stein BM, Barrett RE, et al.: Noradrenergic medication of experimental cerebrovascular spasm. Stroke 1: 356–362, 1970

    PubMed  CAS  Google Scholar 

  • Granowska M, Britton E, Afshar F, et al.: Global and regional cerebral blood flow. Noninvasive quantitation in patients with subarachnoid hemorrhage. J Neurosurg 53: 153–159, 1980

    PubMed  CAS  Google Scholar 

  • Gros C, Minvielle J: Les images de spasme dans les anevrismes intracraniens. Rev Neurol 89: 563–566, 1953

    PubMed  CAS  Google Scholar 

  • Handa J, Matsuda M, Ohtsubo K, et al.: Effect on intracarotid phenoxybenzamine on cerebral blood flow and vasospasm: a clinical study. Surg Neurol 1: 229–232, 1973

    PubMed  CAS  Google Scholar 

  • Handa J, Yoneda S, Matsuda M, et al.: Effect of phenoxybenzamine on experimental cerebral arterial spasm in cats. Surg Neurol 3: 71–74, 1975

    PubMed  CAS  Google Scholar 

  • Hashi K, Meyer JS, Shinmaru S, et al.: Effect of glycerol and intracarotid phenoxybenzamine on cerebral hemodynamics and metabolism after experimental subarachnoid hemorrhage. J Neurol Sci 17: 23–28, 1972

    PubMed  CAS  Google Scholar 

  • Herz DA, Baez S, Shulman K: Pial microcirculations in subarachnoid hemorrhage. Stroke 6: 417–424, 1975

    PubMed  CAS  Google Scholar 

  • Kajikawa H, Ohta T, Yoshikawa Y, et al.: Cerebral vasospasm and hemoglobins—clinical and experimental studies. Neurol Med Chir (Tokyo) 19: 61–71, 1979

    CAS  Google Scholar 

  • Kamiyama K, Okada, H, Suzuki J: The relation between cerebral vasospasms and superoxide application of an experimental model of vasospasm induced by oxyhemoglobin in cats. Neurol Med Chir (Tokyo) 21: 201–209, 1981

    CAS  Google Scholar 

  • Kuschinsky W, Wahl M, Bosse O, et al.: Perivascular potassium and pH as determinants of local pial arterial diameter in cats. A microapplication study. Circ Res 31: 240–247, 1972

    PubMed  CAS  Google Scholar 

  • Kuwayama A, Zervas NT, Shintani A, et al.: Papaverine hydrochloride and experimental hemorrhagic cerebral arterial spasm. Stroke 3: 27–33, 1972

    PubMed  CAS  Google Scholar 

  • Maroon JC, Nelson PB: Hypovolemia in patients with subarachnoid hemorrhage: therapeutic implications. Neurosurgery 4: 223–226, 1979

    PubMed  CAS  Google Scholar 

  • Martins AN, Doyle TF, Newby N, et al.: The effect of a simulated subarachnoid hemorrhage on cerebral blood flow in the monkey. Stroke 6: 644–672, 1975

    Google Scholar 

  • Mchedlishvili G, Ormotsadze L: Responses of the internal carotid artery to different endogenous vasoconstrictor substances. Blood Vessels 16: 126–134, 1979

    PubMed  CAS  Google Scholar 

  • Peerless SJ, Kendall MJ: Experimental cerebral vasospasm. In Whistnant JP, Sandok BA (eds.): Proceedings of the Ninth Princeton Conference on Cerebral Vascular Disease. New York, Grune amp; Stratton, 1975, pp. 49–58

    Google Scholar 

  • Pool JL: Cerebral vasospasm. N Engl J Med 259: 1259–1264, 1958

    PubMed  CAS  Google Scholar 

  • Rice Edwards JM, Bull B, Thompson J, et al.: The role of platelets in causation of cerebral vasospasm. J Neurol Neurosurg Psychiat 39: 828, 1975

    Google Scholar 

  • Rousseaux P, Scherpereel B, Bernard MH, et al.: Fever and cerebral vasospasm in ruptured intracranial aneurysms. Surg Neurol 14: 459–465, 1980

    PubMed  CAS  Google Scholar 

  • Schneck SA: On the relationship between ruptured intracranial aneurysm and cerebral infarction. Neurology 14: 691–702, 1964

    PubMed  CAS  Google Scholar 

  • Van Citters RL, Wagner BM, Rushmer RF: Architecture of small arteries during vasoconstriction. Circ Res 10: 668–675, 1962

    Google Scholar 

  • Walter W, Schütte W: Ãœber die Gefässpasem bei frisch rupturierten sackförmigen Aneurysmen der Hirnarterien. Acta Neurochir 11: 631–652, 1964

    CAS  Google Scholar 

  • Wise G, Sutter R, Burkholder J: The treatment of brain ischemia with vasopressor drugs. Stroke 3: 135–140, 1972

    PubMed  CAS  Google Scholar 

  • Yamaguchi T, Waltz AG: Effects of subarachnoid hemorrhage from puncture of the middle cerebral artery on blood flow and vasculature of the cerebral cortex in the cat. J Neurosurg 35: 664–671, 1971

    PubMed  CAS  Google Scholar 

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White, R.P. (1983). Vasospasm. In: Intracranial Aneurysms. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5437-9_9

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