p-Hydroxyphenylacetic Acid Concentration in the CSF of Patients with Neurological and Psychiatric Disorders
In recent years substantial evidence suggesting that p-tyramine (p-TA) acts as a neurotransmitter or neuromodulator in the brain has been presented (Boulton, 1978; Boulton and Juorio, 1979; Juorio and Jones, 1981). Although the physiological roles of this amine in the central nervous system (CNS) are as yet unknown, it has been claimed that p-TA may be involved in the etiology of certain mental disorders (Boulton and Juorio, 1979; Boulton, 1980). However, there is little clinical evidence for this proposal. p-Hydroxyphenylacetic aid (p-HPAA), a major metabolite of p-TA in the brain (McQuade et al., 1981), has been detected and quantitated in the cerebrospinal fluid (CSF)(Karoum et al., 1975; 1977), but a comparison of p-HPAA concentrations in the CSF of patients with various CNS disorders has not yet been made. We have recently developed a sensitive high-performance liquid chromatographic (HPLC) method for the determination of p-HPAA in CSF (Kobayashi et al., 1982). In this communication we describe CSF levels of p-HPAA in patients with various neurological and psychiatric disorders with special reference to schizophrenia.
KeywordsSchizophrenic Patient HPAA Level Central Nervous System Disorder Hydroxyphenylacetic Acid Pseudobulbar Palsy
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Boulton A. A. (1978) The tyramines: functionally significant biogenic amines or metabolic accidents? Life Sci
. 23, 659–672.PubMedCrossRefGoogle Scholar
Boulton A. A. and Juorio A.V. (1979) The tyramines: are they involved in the psychoses? Biol. Psychiat.
14, 413–419.PubMedGoogle Scholar
Boulton A. A. (1980) The properties and potential function of some brain trace amines. Prog. Clin. Biol. Res
. 39, 291–303.PubMedGoogle Scholar
Juorio A. V. (1977) Effect of chlorpromazine and other antipsychotic drugs on mouse striatal tyramines. Life Sci
. 20, 1663 - 1668.PubMedCrossRefGoogle Scholar
Juorio A. V. and Jones R. S. G. (1981) The effect of mesencephalic lesions on tyramine and dopamine in the caudate nucleus of the rat. J. Neurochem.
36, 1898–1903.PubMedCrossRefGoogle Scholar
Karoum F., Gillin J. C., Wyatt R. J. and Costa E. (1975) Mass-fragmentography of nanogram quantities of biogenic amine metabolites in human cerebrospinal fluid and whole rat brain. Biomed. Mass Spectrom.
2, 183–189.CrossRefGoogle Scholar
Karoum F., Bunney W., Gillin J. C., Jimerson D., Van Kammen D. and Wyatt R. J. (1977) Effect of probenecid on the concentration of the lumbar cerebrospinal fluid acidic metabolites of tyramine, octopamine, dopamine and norepinephrine. Biochem. Pharmacol.
26, 629–632.PubMedCrossRefGoogle Scholar
Kobayashi K., Koide Y. and Shohmori T. (1982) Determination of p-hydroxyphenylacetic acid in cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection. Clin. Chim. Acta
123, 161–168.PubMedCrossRefGoogle Scholar
McQuade P. S., Juorio A. V. and Boulton A. A. (1981) Estimation of the p. ane m isomers of hydroxyphenylacetic acid in mouse brain by a gas chromatographic procedures: their regional distribution and the effects of some drugs. J. Neurochem.
37, 735–739.PubMedCrossRefGoogle Scholar
© The Humana Press Inc. 1984