Abstract
The trace amine phenylethylamine (PE) is an endogenous constituent of mammalian brain tissue (Durden et al, 1973). d-Amphetamine and PE are structurally similar, PE lacking only the α-methyl group of amphetamine. Administration of amphetamine results in a marked attenuation of food and water intake in many species (Bizzi et al, 1970; Holtzman and Jewett, 1971; Soulairac and Soulairac, 1970). Whereas PE has been reported to induce hypophagia (Dourish and Boulton, 1981), several reports have indicated that PE has no effect on fluid consumption (Dourish and Boulton, 1981; 1979; Thornton, 1980). No previous studies, however, have been specifically directed to an analysis of the effects of PE on water intake. The present study, therefore, attempted to reveal any hypodipsic effects of PE by employing a temporal analysis of licking within the test period. In addition to PE and d-amphetamine, the PE derivatives, phenylethanolamine (PEOH) and N-methylphenylethylamine (NMPE) were also included in this study.
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References
Bizzi A., Bonaccorsi A., Jespersen S, Jori A. and Garratini S. (1970) Pharmacological studies on amphetamine and fenfluramine, in Amphetamines and Related Compounds (Costa E. and Garratini S., eds) pp 577–595, Raven Press, New York.
Dourish C.T. and Boulton A.A. (1981) The effects of acute and chronic administration of ß-phenylethylamine on food intake and body weight in rats. Prog. Neuro-psycho-pharmacol. 5, 411–414.
Dourish C.T., Greenshaw A.J. and Boulton A.A. Deuterium substitution selectively enhances the behavioural response to 3~phenylethylamine in rats. Pharmac. Biochem. Behav. (In press).
Durden D.A., Philips S.R. and Boulton A.A. (1973) Identification and Distribution of β-phenylethylamine in the rat. Can. J. Biochem. 51, 995–1002.
Holtzman S.G. and Jewett R.E. (1971) The role of brain norepinephrine in the anorexic effects of dextroamphetamine and monoamine oxidase inhibitors in the rat. Psychopharmacologia 22, 157–161.
Soulairac A. and Soulairac M-L. (1970) Effects of amphetamine-like substances and L-Dopa on thirst, water intake and duiresis, in Amphetamine and Related Compounds ( Costa E. and Garratini S., eds) pp 819–837, Raven Press, New York.
Thornton E.W. (1980) Effect of ß-phenylethylamine on social dominance in rat dyads during competition for water. IRCS Medical Science: Psychology and Psychiatry 8 860–861
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© 1984 The Humana Press Inc.
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Broadbent, J., Greenshaw, A.J., Boulton, A.A. (1984). Hypodipsic Effects of ß-Phenylethylamine, Phenylethanolamine, N-Methylphenylethylamine and d-Amphetamine: A Temporal Analysis. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_36
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DOI: https://doi.org/10.1007/978-1-4612-5312-9_36
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