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Neurobiology of the Trace Amines pp 375–388Cite as

Differentiation of Phenylethylamine (PE)- and Amphetamine (AMPH)-Induced Behaviors

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Abstract

Stereotyped behavior elicited by the chronic administration of the endogenous trace amine, PE, is similar to the behavior induced by AMPH in animals. Both PE and AMPH stereotypies have been proposed as animal paradigms of schizophrenia. In all studies male Sprague-Dawley rats (200–250 grams) were used. PE (50 mg/kg;i.p.) and AMPH (3.75 mg/kg;i.p.) were administered for a minimum of five weeks and animals were rated by a four point stereotypy scale. Pharmacological pretreatments with dopamine (DA) blockers, cholinergic blockers and serotonin (5-HT) blockers were studied on these behaviors. We found that all DA receptor blockers except metaclopramide, antagonized PE stereotypy, whereas clozapine, sulpiride, molindone, and fluperlapine failed to block AMPH behavior. Moreover, 5-HT blockers differentially affected both PE and AMPH stereotypies. In other studies, the direct injection of DA into the nucleus accumbens enhanced stereotypies induced by PE more than those induced by AMPH. The opposite was true when DA was applied to the caudate nucleus. Finally, electrophysiological recordings showed fast frequency spike activity in the caudate nucleus of AMPH treated rats. This same activity was present in the nucleus accumbens of PE treated animals. These results, along with other evidence, suggest that PE and AMPH stereotypy are mediated by different brain areas and mechanisms.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Medical College of Georgia and Augusta V.A. Medical Center, Augusta, Georgia, 30912, USA

    Bruce I. Diamond, Ana Hitri, Chandresh Shah & Richard L. Borison

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  1. Bruce I. Diamond
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  2. Ana Hitri
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  3. Chandresh Shah
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  4. Richard L. Borison
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Editor information

Editors and Affiliations

  1. Psychiatric Research Division, University of Saskatchewan, Saskatoon, Sakastchewan, Canada

    A. A. Boulton

  2. Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada

    G. B. Baker

  3. Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada

    W. G. Dewhurst

  4. The Bernhard Baron Memorial Research, Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte’s Maternity Hospital, London, England

    M. Sandler

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© 1984 The Humana Press Inc.

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Diamond, B.I., Hitri, A., Shah, C., Borison, R.L. (1984). Differentiation of Phenylethylamine (PE)- and Amphetamine (AMPH)-Induced Behaviors. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_32

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  • DOI: https://doi.org/10.1007/978-1-4612-5312-9_32

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9781-9

  • Online ISBN: 978-1-4612-5312-9

  • eBook Packages: Springer Book Archive

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