Abstract
It has been proposed that β-phenylethylamine (PE) may be equivalent to, or may mediate, the effects of d-amphetamine. This hypothesis has been assessed in terms of a comparison of the general stimulus profiles of these two compounds. From the literature it is apparent that PE and d-amphetamine share similar discriminative stimulus properties. This has been demonstrated for PE with and without MAO inhibition. An analysis of effects of PE and d-amphetamine on self-stimulation indicates that their effects are equivalent in this paradigm when PE is administered in the presence of a MAO inhibitor but not in its absence. Self-administration experiments have shown that both compounds may act as rewards or reinforcers in different species. PE is, however, ineffective as a stimulus for the induction of taste aversions, in marked contrast to d-amphetamine. The implications of these data, and the results of some neurochemical analyses, for a possible functional role of PE are discussed.
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Greenshaw, A.J. (1984). β-Phenylethylamine: A Functional Role at the Behavioural Level?. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_31
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DOI: https://doi.org/10.1007/978-1-4612-5312-9_31
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